Mokhtari Brikci-Nigassa, Nahida published the artcileFunctionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest, HPLC of Formula: 69626-75-1, the publication is Bioorganic Chemistry (2020), 103347, database is CAplus and MEDLINE.
Original 1-amino substituted thioxanthone derivatives were easily prepared from the bare heterocycle by a deprotometalation-iodolysis-copper-catalyzed C-N bond formation sequence. This last reaction delivered mono- or/and diarylated products I (R = 4-FC6H4, 1-naphthyl, 3-aminopyridin-2-yl, etc.) and II (R = 4-CH3C6H4, 4-CH3OC6H4) depending on the anilines RNH2 involved. 1-Amino-9-thioxanthone was also prepared and reacted with 2-iodoheterocycles R1I (R1 = 2-thienyl, 1-benzothiophen-2-yl, 1-benzofuran-2-yl). Interestingly, while 1-(arylamino)-9-thioxanthones like 1-(2-thienylamino)-9-thioxanthone and 1-(2-benzothienylamino)-9-thioxanthone could be isolated, their subsequent cyclization was found to deliver original hexacyclic derivatives like [1]benzothiopyrano[4,3,2-de]benzothieno[2,3-b]quinoline and [1]benzothiopyrano[4,3,2-de]benzofuro[2,3-b]quinoline of helicoidal nature. Evaluation of their photophys. properties revealed high fluorescence in polar media, indicating potential applications for biol. imaging. These compounds being able to inhibit PIM1 kinase, their putative binding mode was examined through mol. modeling experiments Altogether, these results tend to suggest the discovery of a new family of fluorescent PIM inhibitors and pave the way for their future rational optimization.
Bioorganic Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, HPLC of Formula: 69626-75-1.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem