Day: November 10, 2022

Yoshida, N. published the artcileReductive dechlorination of PCBs and other chlorinated compounds by novel anaerobic bacterial species, Formula: C8H5ClO2, the main research area is anaerobic bacteria polychlorinated biphenyl chlorinated compound reductive dechlorination.

Bacteria that can reductively dechlorinate chlorinated compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) have been receiving much attention in the field of environmental science and technol. In this study, the enrichment of bacteria that dechlorinate PCBs and PCDDs was performed by the sequentially transferred culture amended with 4,5,6,7-tetrachlorophthalide (fthalide) and single fatty acids from an uncontaminated paddy field. The enrichment cultures amended with lactate (KFL) or formate (KFF) maintained the activity to dechlorinate fthalide to 4-chlorophthalide in the sequential transfer but not the culture amended with acetate and butyrate. The only KFL-culture dechlorinated diverse chlorinated compounds including 2,3,4,5-tetrachlorobiphenyl, 2,3,4-trichlorobiphenyl, 1,2,3-trichlorodibenzo-p-dioxin. A further enrichment of KLF-culture provided an enrichment culture, KFC4A-culture, containing uniformly small short rods. Microbial community anal. based on 16S rRNA genes revealed the involvement of two phylogenetically distinct operational taxonomic units (OTUs) of Dehalobacter sp. (FTH1 and FTH2) with the dechlorination of chlorinated compounds Dehalobacter restrictus TEA was their closest relative, and had 97.5% and 97.3% of 16SrRNA gene similarities for FTH1 and FTH2, resp. These results demonstrate the capacity of uncontaminated paddy soil to dechlorinate PCBs and PCDDs, and the involvement of Dehalobacter sp.

Organohalogen Compounds published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Formula: C8H5ClO2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yoshida, Naoko published the artcileA novel Dehalobacter species is involved in extensive 4,5,6,7-tetrachlorophthalide dechlorination, Category: benzofurans, the main research area is novel Dehalobacter tetrachlorophthalide dechlorination waste fungicide rice blast Dehalobacter.

The purpose of this study was the enrichment and phylogenetic identification of bacteria that dechlorinate 4,5,6,7-tetrachlorophthalide (com. designated “”fthalide””), an effective fungicide for rice blast disease. Sequential transfer culture of a paddy soil with lactate and fthalide produced a soil-free enrichment culture (designated the “”KFL culture””) that dechlorinated fthalide by using hydrogen, which is produced from lactate. Phylogenetic anal. based on 16S rRNA genes revealed the dominance of two novel phylotypes of the genus Dehalobacter (FTH1 and FTH2) in the KFL culture. FTH1 and FTH2 disappeared during culture transfer in medium without fthalide and increased in abundance with the dechlorination of fthalide, indicating their growth dependence on the dechlorination of fthalide. Dehalobacter restrictus TEA is their closest relative, with 97.5% and 97.3% 16S rRNA gene similarities to FTH1 and FTH2, resp.

Applied and Environmental Microbiology published new progress about Dechlorination. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tabanca, Nurhayat published the artcileGas chromatographic-mass spectrometric analysis of essential oils from Pimpinella aurea, Pimpinella corymbosa, Pimpinella peregrina and Pimpinella puberula gathered from Eastern and Southern Turkey, Application In Synthesis of 13391-27-0, the main research area is Pimpinella essential oil terpene phenylpropanoid.

Essential oils from fruits, stems and leaves and roots of Pimpinella aurea DC., P. corymbosa Boiss., P. peregrina L. were analyzed by gas chromatog. (GC) and gas chromatog.-mass spectrometry (GC-MS) techniques. Fruits and aerial parts of P. puberula (DC.) Boiss were also evaluated. A total of 140 different compounds were identified, and significant qual. and quant. differences were observed among the samples. In fact, the main constituents of each species were different and only the oils extracted from roots shared the same principal compound, epoxy pseudoisoeugenyl-2-Me butyrate (26.8-42.8%). The other fractions were dominated by different sesquiterpene compounds although in three of them, P. aurea stem and leaves, P. puberula fruits and P. puberula stems and leaves, monoterpene constituents also appear as main ones.

Journal of Chromatography A published new progress about Gas chromatography. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Application In Synthesis of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Moock, Daniel published the artcileEnantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis, Category: benzofurans, the main research area is octahydrobenzofuran enantioselective preparation; benzofuran preparation enantioselective hydrogenation cascade catalyst; benzofuran; cascade catalysis; enantioselective hydrogenation; heterogeneous catalysis; homogeneous catalysis.

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive mols. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ross, Rachel J. published the artcileRhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening, Related Products of benzofurans, the main research area is rhodium catalyzed diastereoselective intermol cyclopropanation; benzofuran indole alkene cyclopropene ring opening.

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermol. rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a com. available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.

Organic Letters published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Salom-Roig, Xavier J. published the artcilePreparation of substituted hydroquinones and benzofurans from 1,4-quinone monoketals, Related Products of benzofurans, the main research area is hydroquinone preparation; propargylhydroquinone preparation dienone phenol type rearrangement; benzofuran preparation; quinone ketal organometallic addition.

An easy procedure for the preparation of 2-substituted hydroquinones, by addition of organolithium or organomagnesium compounds to 1,4-quinone monoketals followed by acid-catalyzed dienone-phenol type rearrangement, is described. Transformation of the propargylated derivatives to benzofurans is also reported.

Synthesis published new progress about Ketals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhou, Lixin published the artcilePd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans, COA of Formula: C10H10O2, the main research area is methylbenzofuran preparation; iodobenzene aryl bromide intramol Heck reaction palladium catalyst.

A new strategy for the synthesis of 2-methylbenzofurans I (R1 = H, 7-Me, 5-Cl, etc.; R2 = H, Me, COOEt) via the intramol. Heck reaction has been developed. This efficient palladium-catalyzed system showed good catalytic activity. Various substituted 2-methylbenzofurans could be afforded in good to excellent yields.

Tetrahedron Letters published new progress about Aryl iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, COA of Formula: C10H10O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pu, Fan published the artcilePalladium (II)-Catalyzed Decarboxylative Cross-Dehydrogenative Coupling: Direct Synthesis of meta-Substituted Biaryls from Aromatic Acids, Recommanded Product: 4-Chlorophthalide, the main research area is aromatic acid palladium catalyst regioselective tandem oxidative coupling decarboxylation; biaryl preparation.

A palladium-catalyzed tandem process of simple aromatic acids was achieved to afford meta-substituted biaryls in moderate to good yields. The reaction proceeded via carboxyl-directed intermol. cross-dehydrogenative coupling and subsequent decarboxylation. The new C-C bonds in this transformation were formed in the ortho position of carboxyl and the reaction tolerates electron-rich acids. Both sym. and unsym. meta-substituted biaryls were directly synthesized via this method.

Advanced Synthesis & Catalysis published new progress about Biaryls Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Recommanded Product: 4-Chlorophthalide.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Shen, Yu-Dong published the artcileNatural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation, Computed Properties of 13391-27-0, the main research area is tanshinone analog heterocyclic fused ortho quinone preparation cytotoxicity; benzofuranol regioselective Diels Alder reaction dieneamide aminodiene; structure activity relationship tanshinone analog cytotoxicity.

A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives I [R1 = Me, H; R2 = Ar, H; R3 = H, amide group; R4 = R5 = Me, H] were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the mol. could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Computed Properties of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Vargas, David A. published the artcileBiocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds, Quality Control of 50551-63-8, the main research area is diastereoselective enantioselective synthesis dihydrobenzofuran scaffold myoglobin engineering; benzofuran cyclopropanation; biocatalysis; carbene transfer; dihydrobenzofurans; myoglobin.

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive mols. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochem. rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochem. model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug mol. and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asym. C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

Angewandte Chemie, International Edition published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem