Shen, Yu-Dong published the artcileNatural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation, Computed Properties of 13391-27-0, the main research area is tanshinone analog heterocyclic fused ortho quinone preparation cytotoxicity; benzofuranol regioselective Diels Alder reaction dieneamide aminodiene; structure activity relationship tanshinone analog cytotoxicity.
A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives I [R1 = Me, H; R2 = Ar, H; R3 = H, amide group; R4 = R5 = Me, H] were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the mol. could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.
European Journal of Medicinal Chemistry published new progress about Antitumor agents. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Computed Properties of 13391-27-0.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem