Day: November 10, 2022

Song, Shu-Yong published the artcileAn improved and scale-up synthesis of 6-hydroxybenzofuran, Synthetic Route of 50551-63-8, the main research area is hydroxybenzofuran green synthesis scale up.

An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.

Research on Chemical Intermediates published new progress about Green chemistry. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Synthetic Route of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Martin-Santamaria, Sonsoles published the artcileNew scaffolds for the design of selective estrogen receptor modulators, Recommanded Product: 6-Methoxybenzofuran, the main research area is estrogen receptor modulator antitumor pancreatic cancer.

In the present work we report the synthesis of four new ER ligands which can be used as scaffolds for the introduction of the basic side chains necessary for antiestrogenic activity. Affinities and agonist/antagonist characterization of the ligands for both ERα and ERβ have been determined in a competitive radioligand assay, and in an in vitro coactivator recruitment functional assay, resp. Mol. modeling techniques have been used in order to rationalize the exptl. results. Compound 2 is reported as a novel ERβ-agonist/ERα-antagonist. Two compounds show an interesting antitumor profile towards two pancreatic cancer cell lines and have been selected for in vivo assays.

Organic & Biomolecular Chemistry published new progress about Antitumor agents. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fabian, Walter published the artcileInterpretation of the influence of substituents on the UV spectra of benzofurans, Application In Synthesis of 50551-63-8, the main research area is UV benzofuran derivative substituent effect.

The electronic excitation energies of 12 isometric methoxy- and nitrobenzofuran were calculated by means of PPP and CNDO/S-CI method. Based on the results of a configuration anal., a simple mols.-in-mol.-type model is proposed which in a semiquant. manner completely accounts for the characteristic dependence of the UV spectra of these compounds on the position of the substituent.

Zeitschrift fuer Naturforschung, Teil A: Physik, Physikalische Chemie, Kosmophysik published new progress about Quantum chemistry. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Application In Synthesis of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Clough, John M. published the artcileTransition metal-mediated organic synthesis: synthesis of moracin M, Category: benzofurans, the main research area is halobenzofuran metalloresorcinol chromium carbonyl coupling; metallobenzofuran haloresorcinol chromium carbonyl coupling; coupling benzofuran resorcinol palladium catalyst; moracin M.

The Pd-catalyzed cross-coupling of 2-halo- or 2-metallobenzofurans with both 5-metallo- or 5-haloresorcinol tricarbonyl chromium(0) complexes or with the uncomplexed resorcinols, has been evaluated and in consequence, moracin M (I) has been synthesized in good yield by the cross-coupling of 6-(tert-butyldiphenylsiloxy)-2-trimethylstannylbenzofuran with 5-iodoresorcinol bis(triisopropylsilyl) ether and fluoride ion deprotection of the product.

Tetrahedron Letters published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-mediated synthesis of some prenylated phytoalexins of Morus alba Linn, Category: benzofurans, the main research area is moracin prenylated; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran iodoresorcinol chromium carbonyl.

Directed functionalization of resorcinol and benzofuran rings was achieved by activation with a coordinated tricarbonylchromium(0) unit and vicinal or remote lithiation directed by methoxy or tert-butyldiphenylsilyloxy groups resp. The process was applied either before [to the geranylbenzofuran for mulberrofuran B (I, R = Me, R1 = geranyl, R2-R4 = H)] or after [for moracin C (I, R-R2 = H, R3 = prenyl, R4 = Me)] Pd-catalyzed coupling of the 2-stannylated benzofuran and the 5-iodinated resorcinol moieties. In addition moracin I (I, R, R1, R3 = H, R2 = prenyl, R4 = Me) was synthesized by a Stille coupling of the stannylated benzofuran with the phloroglucinol triflate. Application to the synthesis of albafuran A (I, R, R1, R3, R4 = H, R2 = geranyl) gave, unexpectedly, the 3-geranylbenzofuran II.

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-directed synthesis of moracin M, a phytoalexin of Morus alba Linn, Formula: C9H8O2, the main research area is moracin M; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran bromozincbenzofuran iodoresorcinol; iodoresorcinoltricarbonylchromium coupling halobenzofuran.

2-(5-Resorcinyl)benzofurans have been synthesized by the Pd-catalyzed cross-coupling of 2-trimethylstannyl- or 2-bromozincbenzofurans with functionalized 5-iodoresorcinols. These were synthesized by the triisopropylsilyloxy-directed remote (C-5) lithiation/iodination of the O,O-bis(triisopropylsilyl)resorcinoltricarbonylchrhomium(0) complex. The method was applied to the synthesis of moracin M (I).

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Formula: C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xia, Anjie published the artcileMetal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols, Recommanded Product: 6-Methoxybenzofuran, the main research area is metal free oxidative carbon bond cleavage heteroaryl alc.

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Organic Letters published new progress about C-C bond cleavage. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Geng, Pengxin published the artcileA g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations, Name: 4-Chlorophthalide, the main research area is graphitic carbon nitrid heterogeneous photocatalytic benzylic oxygenation; green chem.

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biol. valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this “”green”” methodol. was further demonstrated by applying in bioactive and drug valued target syntheses.

Green Chemistry published new progress about C-H bond activation. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Name: 4-Chlorophthalide.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Martin, R. published the artcileReinvestigation of the phenylpropanoids from the roots of Pimpinella species, Related Products of benzofurans, the main research area is phenylisopropanoid Pimpinella structure; isoeugenol derivative Pimpinella structure; fatty acid ester phenylisopropanoid Pimpinella; linolenate ester phenylisopropanoid Pimpinella.

The roots of P. saxifraga and P. major (Umbelliferae) were reexamined for their isoeugenol derivatives According to high field 1H and 13C NMR, as well as mass spectroscopic studies, the previously described substitution pattern (4-OH, 5-OMe) must be revised to be 2-OH and 5-OMe. A fatty acid ester of a phenylpropanoid was found, its structure was elucidated by 2-dimensional 1H NMR (1H-1H correlated spectroscopy).

Planta Medica published new progress about Pimpinella saxifraga. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Higson, Frank H. published the artcileDegradation of 2-methylbenzoic acid by Pseudomonas cepacia MB2, Application In Synthesis of 52010-22-7, the main research area is Pseudomonas methylbenzoate degradation.

This report describes the isolation of Pseudomonas cepacia MB2, believed to the 1st microorganism to utilize 2-methylbenzoic acid as the sole carbon source. Its growth range included all mono- and dimethylbenzoates (with the exception of 2,5- and 2,6-dimethylbenzoates) and 3-chloro-2-methylbenzoate (but not 4- or 5-chloro-2-methylbenzoate) but not chlorobenzoates lacking a Me group. 2-Chlorobenzoate, 3-chlorobenzoate, and 2,3-, 2,4-, and 3,4-dichlorobenzoates inhibited growth of MB2 on 2-methylbenzoate as a result of cometab. to the corresponding chlorinated catechols which blocked the key enzyme catechol 2,3-dioxygenase. A metapyrocatechase-neg. mutant, MB2-G5, showed accumulation of dimethylcatechols from 2,3- and 3,4-dimethylbenzoates, and phenols were detected in resting-cell transformation extracts bearing the same substitution pattern as the original substrate, presumably following thermal degradation of the intermediate dihydrodiol. 2-Methylphenol was also found in extracts of the mutant cells with 2-methylbenzoate. These observations suggested a major route of methylbenzoate metabolism to be dioxygenation to a carboxy-hydrodiol which then forms a catechol derivative In addition, the Me group of 2-methylbenzoate was oxidized to isobenzofuranone (by cells of MB2-G5) and to phthalate (by cells of a sep. mutant that could not utilize phthalate, MB2-D2). This pathway also generated a chlorinated isobenzofuranone from 3-chloro-2-methylbenzoate.

Applied and Environmental Microbiology published new progress about Burkholderia cepacia. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Application In Synthesis of 52010-22-7.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem