Day: November 10, 2022

Bianco, Armandodoriano published the artcileNew insights on the reaction of benzofurans with aromatic aldehydes. Synthesis of new triphenylmethane-type dyes, Product Details of C9H8O2, the main research area is triphenylmethane dye preparation benzofuran aromatic aldehyde; pH indicator preparation benzofuran aromatic aldehyde; benzofuran coupling aromatic aldehyde dye synthesis.

New mols. with a triphenylmethane-type structure have been synthesized based on the structure of colored compounds obtained from natural substrates. Satisfactory yields were obtained from benzofuran derivatives as starting material, which have been condensed in methanol with aromatic aldehydes in the presence of catalytic amounts of mineral acids. Several of the new compounds behave as pH indicators. The condensation products, obtained from suitably functionalized starting products, can be easily oxidized giving rise to new triphenylmethane-type dyes, such as I.

Gazzetta Chimica Italiana published new progress about Acid-base indicators. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Product Details of C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Soucy, C. published the artcileThe regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides, Product Details of C8H5ClO2, the main research area is phthalide substituted; phthalic anhydride substituted hydride reduction; regiochem reduction substituted phthalic anhydride.

The reduction of 3-methoxyphthalide by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qual. interpretation of the results was proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed.

Journal of Organic Chemistry published new progress about LUMO (molecular orbital). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Product Details of C8H5ClO2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Margrey, Kaila A. published the artcilePredictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis, Safety of 5-Methoxy-2-methylbenzofuran, the main research area is site selective aryl heteroaryl functionalization organic photoredox catalysis.

Direct C-H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to pharmaceuticals, agrochems., and late-stage functionalization reactions on complex mols. On the basis of previous methods disclosed by our lab, we sought to develop a predictive model for site selectivity and extend this aryl functionalization chem. to a selected set of heteroaromatic systems commonly used in the pharmaceutical industry. Using electron d. calculations, we were able to predict the site selectivity of direct C-H functionalization in a number of heterocycles and identify general trends observed across heterocycle classes.

Journal of the American Chemical Society published new progress about Amination, regioselective. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Safety of 5-Methoxy-2-methylbenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rehan, Mohammad published the artcileSynthesis of Functionalized Benzo[b]furans via Oxidative Cyclization of o-Cinnamyl Phenols, Synthetic Route of 13391-27-0, the main research area is cinnamyl phenol palladium oxidative cyclization catalyst; benzofuran benzyl preparation.

Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-benzyl benzo[b]furans I (R1 = 5-Me, 5-OMe, 5-Ph, 4,6-diMe, etc.; R2 = Ph, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, H, Me, etc.; Ar = Ph, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 1-naphthyl, etc.) via a regioselective 5-exo-trig intramol. oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and benzoquinone as an oxidant. Further, a sequential ortho-cinnamylation of phenols using cinnamyl alcs. catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed. The reaction showed broad substrate scope with good to excellent yields.

Journal of Organic Chemistry published new progress about Alkenylation, cinnamylation. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Synthetic Route of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Paymode, Dinesh J. published the artcileStudies toward the Total Synthesis of Parvifolals A/B: An Intramolecular o-Quinone Methide [4 + 2]-Cycloaddition To Construct the Central Tetracyclic Core, Category: benzofurans, the main research area is parvifolol tetracyclic core preparation cycloaddition.

Two different approaches comprising the intramol. [4+2]-cycloaddition of in situ generated o-quinone methides (o-QMs) have been explored to construct the central tetracyclic core of parvifolols A/B. At the outset, a cross-pinacol coupling of 2-formyl-tri-O-Methylresveratrol with 4-methoxysalicylaldehyde followed by acid treatment were found to provide the desired tetracyclic core (I) with an internal olefin. The requisite pendant aryl group has been introduced by a Pd-catalyzed direct coupling of corresponding diazonium salt.

ACS Omega published new progress about [4+2] Cycloaddition reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kubeczka, K. H. published the artcileThe compositions of the essential root oils from Pimpinella saxifraga s.l. and chemotaxonomic implications, HPLC of Formula: 13391-27-0, the main research area is Pimpinella root oil composition chemotaxonomy; sesquiterpene Pimpinella root oil chemotaxonomy.

The essential root oils of the P. saxifraga subspecies eusaxifraga, alpestris and nigra were investigated by means of capillary GC and spectroscopic methods. A total of 48 components was identified. Characteristic constituents of all oils are pseudoisoeugenol derivatives, sesquiterpenoids and trinor-sesquiterpene hydrocarbons, but the qual. and quant. patterns of the individual oils exhibit significant differences. The results obtained were discussed in regard to a chemotaxonomic reliable delimitation of the 3 described subspecies of P. saxifraga.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about Pimpinella saxifraga alpestris. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, HPLC of Formula: 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Okuyama, Tadashi published the artcileSubstituent effects in the benzofuran system. I. Proton and carbon-13 chemical shifts, Name: 6-Methoxybenzofuran, the main research area is NMR benzofuran substituent effect.

PMR and 13C NMR spectra of benzofuran and its derivatives (2-Me, 3-Me, 5-Me, 6-Me, 5-MeO, 6-MeO, 5-Cl) have been measured. The chem. shifts of 2-H and 2-C of 5- and 6-substituted derivatives obeyed a modified Hammett equation, δ = ρ1σ1 + ρ2σ2 +δ0. Electronic effects were transmitted mainly through the bond 8-3. The ground state electronic structure was similar to that of styrene rather than phenyl vinyl ether.

Bulletin of the Chemical Society of Japan published new progress about Linear free energy relationship. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Name: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Boykin, David W. published the artcileOxygen-17 nuclear magnetic resonance spectroscopic study of substituted phthalic anhydrides and phthalides, Category: benzofurans, the main research area is NMR oxygen phthalic anhydride phthalide.

17O chem. shift data (natural abundance) for 3-substituted phthalic anhydrides and 4- and 7-substituted phthalides in acetonitrile at 75° are reported. Steric interactions of substituents ortho to the carbonyl groups result in deshielding effects (9-22 ppm) relative to parent compounds regardless of the electronic character of the substituents. Factors contributing to the deshielding effects are discussed. The relationship between 17O chem. shifts and regiochem. of the phthalic anhydrides is discussed.

Canadian Journal of Chemistry published new progress about NMR (nuclear magnetic resonance). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Jun published the artcilePalladium-Catalyzed Regioselective C-2 Arylation of Benzofurans with N’-Acyl Arylhydrazines, Recommanded Product: 6-Methoxybenzofuran, the main research area is benzofuran acyl arylhydrazine palladium catalyst TEMPO regioselective arylation; arylbenzofuran preparation.

A novel ligand-free palladium-catalyzed C-2 arylation of benzofurans has been developed using N’-acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional-group tolerance and highly regioselective products with good to excellent yields.

European Journal of Organic Chemistry published new progress about Arylation catalysts (regioselective). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Menkir, Mengistu Gemech published the artcileThe role of cesium fluoride in aryl propargyl ether Claisen rearrangement and its mechanistic elucidation: a theoretical study, Formula: C10H10O2, the main research area is cesium fluoride aryl propargyl ether Claisen rearrangement mechanistic theor.

The role of cesium fluoride (CsF) in aryl propargyl ether Claisen rearrangement and its mechanistic pathway were studied in gas and solvent phase using the d. functional theory implemented in Gaussian 09. Results indicate that the [3,3]-sigmatropic rearrangement is the rate-limiting step with ΔG‡ value of 37.1 kcal/mol in solvent phase. Also, the enolization of α-allenylketone intermediate (Int1-CsF) has a higher free energy barrier, which implies that the formation of benzopyran is not favored in the presence of CsF. However, the abstraction of the α-hydrogen atom in Int1-CsF with CsF shows a very low free energy barrier and is the most favored pathway for aryl propargyl ether Claisen rearrangement in the presence of CsF to form benzofuran. In the case of substituted aryl propargyl ethers, a methoxy group on the benzene ring lowers the activation barrier. The HOMO-LUMO, conformational and NBO anal. indicate that increasing Me substitution on the propargyl residue enhances the rearrangement reaction.

Structural Chemistry published new progress about [3,3]-Sigmatropic rearrangement (rds). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Formula: C10H10O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem