Day: October 17, 2022

《Synthesis and some CNS activities of new benzofuranylacryloylpiperazines》 was published in European Journal of Medicinal Chemistry in 1995. These research results belong to Dauzonne, D.; Gillardin, J. M.; Lepage, F.; Pointet, R.; Risse, S.; Lamotte, G.; Demerseman, P.. Quality Control of 6-Methoxybenzofuran-2-carbaldehyde The article mentions the following:

A series of novel [(benzofuranyl)acryloyl]piperazines, which are structurally related to both cinnamide derivatives and befuraline, have been prepared as their hydrochlorides. Their anticonvulsant and antidepressant activities against seizures induced by electroshock and against tetrabenazine-induced palpebral ptosis have been evaluated in mice. Some of them revealed interesting potencies since, although they are less active than the reference drugs, they exhibited a higher protective index. The experimental process involved the reaction of 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Quality Control of 6-Methoxybenzofuran-2-carbaldehyde)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Quality Control of 6-Methoxybenzofuran-2-carbaldehydeBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 1975,Bulletin de la Societe Chimique de France included an article by Rene, Loic; Buisson, Jean P.; Royer, Rene. Application In Synthesis of Ethyl 6-methoxybenzofuran-2-carboxylate. The article was titled 《Reactions induced by pyridinium halides. XX. First examples of dealkylation by pyridinium hydrochloride in quinoline》. The information in the text is summarized as follows:

Benzofuranols I-VI (R = R1 = H, R2 = H, Me) were prepared in improved yields by demethylating I-VI (R1 = Me) with pyridine-HCl in quinoline. I-VI (R1 = Me) were prepared by formylating coumarilic acid esters, hydrolyzing I-VI (R = CO2Me, CO2Et, R1 = Me), and decarboxylating I-VI (R = CO2H). In addition to this study using Ethyl 6-methoxybenzofuran-2-carboxylate, there are many other studies that have used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Application In Synthesis of Ethyl 6-methoxybenzofuran-2-carboxylate) was used in this study.

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Application In Synthesis of Ethyl 6-methoxybenzofuran-2-carboxylateBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 1977,European Journal of Medicinal Chemistry included an article by Fatome, Marc; Andrieu, Louis; Laval, Jean Denis; Clavel, Jean Marc; Blanco, Luis; Guillaumel, Jean; Rene, Loic; Royer, Rene. Safety of 6-Methoxybenzofuran-2-carbaldehyde. The article was titled 《Comparison of radioprotective activities of similar substituted derivatives of benzofurane and 2H-chromene》. The information in the text is summarized as follows:

The radioprotective activities of I(R1, R2, R3, R4 = H, OMe; Z = MeCO, CHO, CN, CO2Et) were less than those of II (same substituents as I). In the experiment, the researchers used many compounds, for example, 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Safety of 6-Methoxybenzofuran-2-carbaldehyde)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Safety of 6-Methoxybenzofuran-2-carbaldehydeBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The author of 《Benzofurans. LIV. New access to hydroxybenzofurans》 were Rene, Loic; Royer, Rene. And the article was published in Bulletin de la Societe Chimique de France in 1973. Category: benzofurans The author mentioned the following in the article:

Hydroxybenzofurans were prepared in overall yields I 70, II 60, III 30, IV 55%, by cyclizing methoxysalicylaldehydes with ClCH2CO2Et to a mixture of Et methoxycoumarilate, methoxycoumarilic acid, and methoxybenzofuran. The coumarilic acid derivatives were decarboxylated with Cu in quinoline and the methoxybenzofurans were demethylated by pyridine-HCl. The experimental process involved the reaction of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Category: benzofurans)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Category: benzofuransBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Gold nanoshells coated 5-aminolevulinic liposomes for photothermal-photodynamic antitumor therapy》 was written by Jiang, Yifei; Liu, Yang; Fang, Siyuan; Ji, Min. SDS of cas: 5471-63-6 And the article was included in Journal of Nanoscience and Nanotechnology in 2020. The article conveys some information:

In this study, a novel antitumor system was designed on the basis of photodynamic therapy and photothermal therapy using gold nanoshells coated 5-aminolevulinic acid (5-ALA) liposomes (GNALs). As a widely used photosensitizer prodrug, 5-aminolevulinic acid (5-ALA)-derived protoporphyrin IX (PpIX) can accumulate to a higher level in tumors than in normal tissues. Protoporphyrin IX (PpIX) initiates a series of cytotoxic reactions after irradiation of target tissue with a measured dose of light with appropriate wavelength, which may be dependent on the generation of reactive oxygen species. Gold nanoshells can strongly absorb NIR lasers at the same time, and can generate hyperthermia to provide photothermic effects. Gold nanoshells coated 5-ALA-Liposomes (GNALs) exhibit a uniform-sized spherical shape of 185.8±0.91 nm, with a zeta potential of 33±1.6 mV. Liposomes with specific sizes ranging from 100 to 200 nm can escape into the tumor interstitial tissue and accumulate preferentially in tumor tissue owing to the EPR effect. In addition, NIR light-excited nanosystems significantly promoted antitumor effects in this study compared to single photodynamic therapy. It was also found that the increased temperature promoted inhibition rate of SKOV3 cells. The novel drug delivery system shows great potential in photothermal-photodynamic antitumor therapy. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C12H12O4On October 15, 2008 ,《Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho. The article contains the following contents:

The synthesis of a novel series of aminostyrylbenzofurans I (R1, R2 = H, Br, Cl, F, I, OH, OMe; R3 = NH2, NHMe, NMe2; R4 = H, OMe) and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds I (R1 = R4 = H; R2 = OMe; R3 = NMe2) and I (R1 = OMe, R2 = R4 = H; R3 = NHMe) exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, resp.) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds Both compounds were selected as promising candidates for further biol. evaluation. In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0COA of Formula: C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.COA of Formula: C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 50551-57-0On October 1, 2010 ,《Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI》 was published in Bioorganic & Medicinal Chemistry. The article was written by Giorgioni, Gianfabio; Ambrosini, Dario; Vesprini, Cristian; Hudson, Alan; Nasuti, Cinzia; Di Stefano, Antonio; Sozio, Piera; Ciampi, Osele; Costa, Barbara; Martini, Claudia; Carrieri, Antonio; Carbonara, Giuseppe; Enzensperger, Christoph; Pigini, Maria. The article contains the following contents:

Based on the well known biol. versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline mols. as D2-like dopamine receptor ligands. Conservative chem. modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided partial (3f)(I) or nearly full (3e and 3h) agonists, all endowed with D2-like potency comparable to that of dopamine. The experimental part of the paper was very detailed, including the reaction process of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Xiao-Hui; Wei, Xiao-Fei; Liu, Jin-Hua; Yang, Wei; Liu, Yuan-An; Cheng, Kun; He, Xiao-Ying; Fu, Xiu-Li; Zhang, Yu; Zhang, Hong-Xin published an article in 2021. The article was titled 《Chlorin e6-1,3-diphenylisobenzofuran polymer hybrid nanoparticles for singlet oxygen-detection photodynamic abaltion》, and you may find the article in Methods and Applications in Fluorescence.Recommanded Product: 5471-63-6 The information in the text is summarized as follows:

Adual-functional nanosysterm is developed by means of Chlorin e6 (Ce6) as photosensitizer and 1,3- Diphenylisobenzofuran (DPBF) as fluorescent singlet oxygen (1O2) probe. Under 660 nmlaser irradation, Ce6 exhibites efficient 1O2 generation, and subsequently the production of 1O2 is assessed by the ratiometric fluorescence of PFO and DPBF under one-photon and two-photon excitation mode. The nanoparticles with excellent biocompatibility can be internalized into Hela cells and applied for tumor treatment. For intracellular PDT, the nanoparticles perform a high phototoxicity, while the PDT proccess can be evaluated in time by monitoring fluorescence signals of DPBF. This theranostic nanosysterm provides a facile strategy to fabricate 1O2-detection PDT, which can realize accurate and efficient photodynamic therapy based on singlet oxygen detection. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem