Heterocyclic Building Block-benzofuran

196799-45-8, 2,3-Dihydrobenzofuran-7-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,3-Dihydro-benzofuran-7-carbaldehyde (1.50 g, 10.20 mmol) was dissolved in ether, then cooled to 0 C., NaBH4 (400 mg, 10.57 mmol) in MeOH (5.00 mL) was added. The resulting reaction mixture was stirred for 30 min, then saturated ammonium chloride was added. The mixture was extracted with ether, and the combined organic phases were washed with brine, then dried over magnesium sulfate and concentrated to afford the desired alcohol

196799-45-8, 196799-45-8 2,3-Dihydrobenzofuran-7-carbaldehyde 2795018, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Allergan, Inc.; US2008/255230; (2008); A1;,
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64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromoisobenzofuran-1(3H)-one (21.3 g, 100 mmol) in DCM (200 mL) was added diisobutylaluminum hydride (184 g, 130 mmol) at -78 C. The reaction was stirred at -78 C. until the reaction was complete (?2 h). 10 mL water was added, and 10 mL 4M NaOH (aq.) was added, then 40 mL was water was added, the mixture was stirred at room temperature for 30 mins. The mixture was filtered, the filtrate was concentrated. The resulting solid was purified by flash column chromatography (petroleum ether:EtOAc 100:0 to 80:20) to provide 285 5-bromo-1,3-dihydroisobenzofuran-1-ol (13 g, 60.4 mol) as a white solid. MS (ESI): m/z 196.9 [M-16+1]+., 64169-34-2

As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; XIE, Linghong; HEFFERNAN, Michele L.R.; JONES, Philip Glyn; HANANIA, Taleen G.; (95 pag.)US2018/30064; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.

Tribromide (2.86 g, 10 mmol) was dissolved in chloroform (10 mL)Cooled to -50 , slow6-hydroxy-2,3-dihydrobenzofuran (1.36 g, 10 mmol) and triethylamine (1.212 g, 12Mmol) in dichloromethane (10 mL)The After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C2 hours. The reaction was further cooled to -60 C and L-alanine-4-fluorobenzyl ester hydrochloride was addedSalt (2.1 g, 9 mmol) was added dropwise to a solution of triethylamine (2.53 g, 25 mmol) in dichloromethane (5ML). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C for 2 hours. Further the reaction is carried outWas cooled to -60 C and pentafluorophenol (1.66 g, 9 mmol) and triethylamine (1.52 g, 15Mmol) in dichloromethane (10 mL). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C6 hours. The reaction was complete and the reaction system was poured into ice water and extracted with dichloromethane. CollectionAnd the organic phase was washed with saturated brine aqueous solution, dried and concentrated by filtration to give the intermediate compound(6-fluorobenzyl) -2 – ((pentafluorophenoxy) (benzofuran-6-oxy) phosphoryl) amino)Propionate.

13196-11-7, The synthetic route of 13196-11-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.; Liu, Gang; Yu, Nan; Wu, Yongyong; Tang, Zuijian; Zheng, Xiaozhou; Chen, Qiangqiang; Deng, Hanwen; Duan, Xiaofan; Song, Shuai; Yang, Long; Li, Shai; Huang, Haitao; Zhang, Yitao; Zhao, Mingliang; Deng, Hua; Zhong, Wei; Li, Donghong; Ceng, Hong; Guo, Xianfen; Song, Hongmei; Tao, Lihua; Wang, Lichun; Wang, Jingyi; Other inventors request an unlisted name; (127 pag.)CN106554382; (2017); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

Add phenol (20.4g, 0.22mol) and DMF 50mL to the reaction flask and start stirring.5-Bromoisobenzofuran-1(3H)-one (34.0 g, 0.16 mmol), acetylacetone (3.2 g, 0.03 mol), cuprous bromide (3.6 g, 0.03 mol), potassium carbonate (at room temperature) 30.8g, 0.22mol), three times of nitrogen replacement, heating to 90 C, stirring reaction overnight, adding 1000 mL of purified water to the reaction solution, suction filtration, the filter cake was dissolved in 800 mL of dichloromethane, and the organic phase was washed with 800 mL of 1N hydrochloric acid solution, with purified water. 1000 mL washing, drying the organic phase, and concentrating to dryness under reduced pressure to give a yellow solid.The title compound 2b (22.5 g, 63%) was obtained.

64169-34-2, As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
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652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,652-39-1

The subtitle compound is prepared according to the procedure adapted from C.G. Thomson et a.., Bioorg. Med. Chern. Letters 2006, 16(5), 1388-1391: 3-fluorophthalic acid anhydride (29.7 mmol) is reacted with phenyl acetic acid (59.4 mmol) in Ac2O (16 mL) in the presence of NEt3 (21 mL) at reflux, followed by treatment with 30percent sol. of NaOMe in MeOH (48 mL) at reflux.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; FRETZ, Heinz; GATFIELD, John; ISLER, Markus; KIMMERLIN, Thierry; KOBERSTEIN, Ralf; LYOTHIER, Isabelle; MONNIER, Lucile; POTHIER, Julien; VALDENAIRE, Anja; WO2013/68785; (2013); A1;,
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37418-88-5, 4-Hydroxyisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Decanoyl chloride (20 mul, ca. 0.1 mmol) in THF (2 ml) was cooled to 0 ¡ãC, and a solution of 1 (16.4 mg, 0.1 mmol) in THF (1.5 ml) was added dropwise; the mixture was stirred under 15 ¡ãC for 4 h. After this time, water was added and extracted with dichloromethane, then successively washed with H2O and brine. The organic layer was dried with MgSO4, and evaporated to give a crude product, which was chomatographed on silica gel eluting with CHCl3-MeOH to give 20 (70percent): white oil; 1H NMR (CDCl3, 400 MHz): delta 0.84 (t, J = 7.2 Hz, 3H), 1.23 (m, 12H), 1.72 (m, 2H), 2.24 (t, J = 6.4 Hz, 2H), 6.62 (d, J = 7.6 Hz, 1H), 6.64 (d, J = 8.0 Hz, 1H), 7.14 (t, J = 8.0 Hz, 1H); 13C NMR (CDCl3, 100 MHz): delta 172.3, 163.7, 163.5, 154, 143.1, 134.3, 130.1, 127.0, 126.7, 33.5, 31.9, 29.7, 29.4, 29.1, 25.1, 22.8, 14.1; HRFABMS m/z 319.1381 [M+H]+., 37418-88-5

37418-88-5 4-Hydroxyisobenzofuran-1,3-dione 96580, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Xiao, Bin; Yin, Jun; Park, Minhi; Liu, Juan; Li, Jian Lin; Kim, Eun La; Hong, Jongki; Chung, Hae Young; Jung, Jee H.; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 4954 – 4961;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

2,2-Diphenyl-2-pyrrolidin-3-yl-acetamide (2, 2.8 g, 0.01 mol) and 5-(2-bromoethyl)-2,3-dihydrobenzofuran (3, 4.54 g, 0.02 mol) were refluxed in acetone (70 mL) containing K2CO3 (2.76 g, 0.02 mol). After completion of the reaction mass was concentrated under vacuum and the obtained residue was poured into water. The separated solid was filtered and dried. The crude product was purified over silica gel column using MDC: MeOH (99:1 to 96:4) as eluent to obtain product in 4 g yield. IR (KBr): 3220, 3056, 2946, 2856, 1698, 1614, 1491, 1443, 1359, 1243, 1219, 1101, 1076, 814, 752,701 cm-1; 1H MNR (300 MHz, CDCl3): delta 0.68 (m, 1H), 1.40-1.44 (m, 1H), 2.41-2.61 (m, 2H), 2.41-2.61 (m, 2H), 2.75-3.16 (m, 1H), 2.78 (m, 1H), 3.08 (t, J=8.6 Hz, 2H), 3.20-3.25 (m, 1H), 3.23-3.60 (m, 1H), 3.38-3.43 (m, 1H), 4.44 (t, J=8.9 Hz, 2H), 6.62 (d, J=8.1 Hz, 1H), 6.84 (d, J=8.1 Hz, 1H), 6.90 (d, J=6.9 Hz, 4H), 6.98 (s, 1H), 7.20-7.33 (m, 2H), 7.40 (d, J=6.6 Hz, 4H), 8.15 (brs, 1H); 13C NMR (75 MHz, CDCl3): delta 27.55, 29.06, 32.22, 40.06, 43.41, 50.94, 70.58, 108.36, 125.16, 126.33, 126.51, 126.96, 127.46, 127.69, 127.77, 128.55, 132.13, 141.18, 141.73, 157.81, 176.85; DIP MS: m/z (percent) 573 [M+H]+ (100). Anal. Calcd for C38H40N2O3: C, 79.69; H, 7.04; N, 4.89. Found: C, 79.48; H, 7.10; N, 4.79percent., 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
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50551-63-8,50551-63-8, 6-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 207 To a solution of 6-methoxybenzofuran (16.9 g) in collidine (200 ml) was added lithium iodide (30.5 g), and the mixture was refluxed under argon atmosphere for 1 day and cooled. To the mixture was added 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with 2N hydrochloric acid (5 times) and then washed with water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography to give dark brown oil of 6-hydroxybenzofuran (2.9 g). 1H-NMR (200 MHz, CDCl3) delta 8 5.04 (s, 1H), 6.69 (dd, 1H, J=2.6, 1.0 Hz), 6.79 (dd, 1H, J=8.4, 2.2 Hz), 7.00 (d, 1H, J=2.0 Hz), 7.42 (d, 1H, J=8.4 Hz), 7.52 (d, 1H, J=2.2 Hz).

As the paragraph descriping shows that 50551-63-8 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6235771; (2001); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Preparation of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) To a solution of n-BuLi (1.7 M, 123 ml, 0.21 mol) in 400 ml of hexane at room temperature was added 24.3 g (0.21 mol) of N,N,N’,N’-tetramethylethylenediamine (TMEDA), followed by a hexane (40 ml) solution of 2,3-dihydrobenzo[b]furan (14) (12.56 g, 0.11 mol). The mixture was stirred under argon at room temperature for 4 hours, and then poured into dry ice (pre-washing with anhydrous ether). After stirring at ambient temperature overnight, the mixture was diluted with water (300 ml), and the layers separated. The aqueous layer was acidified with conc. HCl to pH 1, cooled and the precipitate collected on a filter. This was recrystallized from CH2Cl2 to give 15a (9.43 g, 54.7%) as a white solid, mp 167-169.5C., 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
Benzofuran – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-10-1,5-Chlorobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-aminopiperidine-l-carboxylate (1.02 g, 5.10 mmol, 1.0 equiv) in DMF (10 mL) was added 5-chlorobenzofuran-2 -carboxylic acid (1 .0 g, 5.1 mmol, 1.0 equiv) and HATU (3.800 g, 10.02 mmol, 2.0 equiv) at RT. The resulting reaction mixture was stirred for 10 minutes and DIPEA (2.5 mL, 15.00 mmol, 3.00 equiv) was added. The reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (100 mL c 2). Combined organic extracts were washed with water (20 mL *4), dried over anhydrous NaaSOr and concentrated. The crude product obtained was treated w ith ether- hexane (50:50) to obtain tert-butyl 4-(5-chlorobenzofuran-2-carboxaniido)piperidine-1 – carboxylate (0.800 g, 43% yield) as an off-white solid. LCMS: 379.2 [M+H] 2

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
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