Heterocyclic Building Block-benzofuran

Visualization and quantification of penetration/mass transfer of acrylic resin retanning agent in leather using fluorescent tracing technique was written by Zeng, Yunhang;Song, Ying;Li, Jing;Zhang, Wenhua;Shi, Bi. And the article was included in Journal of the American Leather Chemists Association in 2016.HPLC of Formula: 3326-34-9 This article mentions the following:

Acrylic resin is a widely used retanning agent in leather processing, and its retanning effectiveness is closely related to its penetration depth and filling parts in leather. But acrylic resin in leather cannot be visualized or quantified, and thus its application mainly depends on tanner’s experience. In this study, 5-aminofluorescein-labeled poly(acrylic acid) (AF-PAA), as a model of fluorescent acrylic resins, was synthesized using a phase-transfer reaction and then purified using Sephadex gel filtration. AF-PAA was applied to retanning process and could be well visualized and quantified in retanned leathers using fluorescence microscopy and Image J software. Looser collagen fibers, increasing amount of acrylic resin or retanning together with some anionic retanning agents could enhance penetration/mass transfer of acrylic resin in leather. The fluorescent tracing technique is useful to investigate the mass transfer and reaction mechanism of acrylic resin in leather processing. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9HPLC of Formula: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.HPLC of Formula: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Site-Selective Functionalization of (sp³)C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor was written by Gu, Yang;Natoli, Sean N.;Liu, Zhennan;Clark, Douglas S.;Hartwig, John F.. And the article was included in Angewandte Chemie, International Edition in 2019.Computed Properties of C8H7NO3 This article mentions the following:

The selective functionalization of one C-H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex mols. We report site-selective functionalizations of C-H bonds, differentiated solely by remote substituents, catalyzed by artificial metalloenzymes (ArMs) that are generated from the combination of an evolvable P 450 scaffold and an iridium-porphyrin cofactor. The generated systems catalyze the insertion of carbenes into the C-H bonds of a range of phthalan derivatives containing substituents that render the two methylene positions in each phthalan inequivalent. These reactions occur with site-selectivity ratios of up to 17.8:1 and, in most cases, with pairs of enzyme mutants that preferentially form each of the two constitutional isomers. This study demonstrates the potential of abiotic reactions catalyzed by metalloenzymes to functionalize C-H bonds with site selectivity that is difficult to achieve with small-mol. catalysts. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Computed Properties of C8H7NO3).

5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C8H7NO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cell-Penetrating Homochiral Cyclic Peptides as Nuclear-Targeting Molecular Transporters was written by Mandal, Deendayal;Shirazi, Amir Nasrolahi;Parang, Keykavous. And the article was included in Angewandte Chemie, International Edition in 2011.Electric Literature of C19H30N4O5S This article mentions the following:

The authors report the design and evaluation of amphipathic homochiral L-cyclic peptides for potential applications as cell-penetrating peptides or mol. transporters of bioactive compounds To examine the potential application of the cyclic peptides as mol. transporters, a model experiment was performed with lamivudine. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Electric Literature of C19H30N4O5S).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C19H30N4O5S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tolerability of mycophenolate mofetil in elderly kidney transplant recipients: A retrospective cohort study was written by Witek, Stephanie;Malat, Gregory;Sawinski, Deirdre;Sammons, Chelsea;LaFratte, Christopher;Forte, Abigail;Samudralwar, Rahul;Lyle, Sandra;Rashid, Jamal;Trofe-Clark, Jennifer. And the article was included in Clinical Transplantation in 2022.Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

Optimal immunosuppression in elderly kidney transplant recipients (KTRs) is not well defined, with mycophenolate mofetil (MMF) being poorly tolerated. Study aim was to compare MMF dose reduction incidence and reason(s) in elderly vs. nonelderly KTRs in the 1st year after transplant with a protocol dose of 1 g/day. In this single-center retrospective study, first or repeat KTRs receiving rabbit antithymocyte globulin (rATG), MMF 1 g/day, tacrolimus, and prednisone, were stratified by age [≥60 (elderly) or <60 years (nonelderly)]. Primary outcome was MMF dose reduction incidence in the first year. Secondary outcomes included dose reduction rationale, 1-yr patient and graft survival, graft function, rejection, infection, hospital presentation, and time to dose reduction Of 335 KTRs, dose reduction incidence was significantly greater in the elderly group (66% and 54%, p = 0.04), though this did not remain significant when adjusted for sex, race, and valganciclovir use. Most common rationale was leukopenia in the elderly group and CMV in the nonelderly group. There were no significant differences in secondary outcomes. Mycophenolate mofetil 1 g/day was poorly tolerated in both elderly and nonelderly KTRs receiving lymphocyte-depleting induction with a high incidence of dose reductions; however, no short-term adverse graft outcomes were identified. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Name: (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kinetics of the opening and closing of lactone rings. Structural influence. II. Study on ortho substituted phthalides. Application of the Hammett equation was written by Vene, J.;Tirouflet, J.. And the article was included in Bulletin de la Societe Chimique de France in 1954.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

Rate constants, energies of activation and entropy factors for the alk. hydrolysis of phthalides, substituted in the position ortho to the carboxyl were determined The results are analyzed considering the Hammett equation and the latter is found to be applicable to this case. Stearic factors enter into the reaction as they do in the case of the benzoates. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chiral precursors for syntheses of furanoterpenes was written by Marco, Jose L.. And the article was included in Tetrahedron in 1989.Category: benzofurans This article mentions the following:

The synthesis of (2S,4R,5R)- and (2R,4R,5R)-2-(3-furyl)-4,5-isopropylidenedioxytetrahydrofuran (I) and (2S,4R,5S)-5-ethoxy-2-(3-furyl)-4-hydroxytetrahydrofuran (II) from “diacetone glucose” (III) is described. A new approach to 1-(R) and 1-(S)-(3-furyl)-1,2-dihydroxyethane (IV) from L-serine and D-mannitol, resp., is described. These compounds are convenient chiral precursors for syntheses of furanoterpenes. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Category: benzofurans).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Semiquantitative naked-eye detection of synthetic food colorants using highly-branched pipette tip as an all-in-one device was written by Wang, Shuangshou;Li, Wenzhi;Yuan, Zhihong;Jin, Qiwen;Ding, Zongpeng;Liu, Xiaomeng;Ye, Mingfu;Gu, Jing;Yan, Tingxuan;Chen, Hongmei;Chen, Yang. And the article was included in Analytica Chimica Acta in 2022.SDS of cas: 16423-68-0 This article mentions the following:

The existing strategies for the determination of synthetic food colorants (FCs) in manufactured foods are highly relied on specialized instruments and skilled personnel which are limited by the high tech. threshold and instrumentation cost. Herein, highly branched pipet tips (PTs) were fabricated as a robust all-in-one device for high-performance extraction and visual detection of FCs via handy aspiration and dispensing procedures of pipet controller. The d. of extraction groups and inner sp. surface area of PTs greatly increased after facile phys. coating and subsequent layer-by-layer branching reactions, and the maximum increment in binding capacity of PTs was exceeded 300 times at 8-10 iterations of branching layers, enabling the PTs to be colored just by short-time extraction of FCs and to achieve the instrument-independent visual detection of FCs by virtue of their outstanding PT-SPE performance. As a proof-of-concept, the in-situ PT-based solid phase extraction (PT-SPE) with high recoveries (from 91.73 ± 4.76% to 99.90 ± 4.14%) and semiquant. naked-eye detection of FCs (Allura red and brilliant blue) in real beverages were exptl. demonstrated to be highly feasible by comparison with classical techniques like spectrophotometry, HPLC, and mass spectrometry. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0SDS of cas: 16423-68-0).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.SDS of cas: 16423-68-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 was written by Kallander, Lara S.;Washburn, David;Hilfiker, Mark A.;Eidam, Hilary Schenck;Lawhorn, Brian G.;Prendergast, Joanne;Fox, Ryan;Dowdell, Sarah;Manns, Sharada;Hoang, Tram;Zhao, Steve;Ye, Guosen;Hammond, Marlys;Holt, Dennis A.;Roethke, Theresa;Hong, Xuan;Reid, Robert A.;Gampe, Robert;Zhang, Hong;Diaz, Elsie;Rendina, Alan R.;Quinn, Amy M.;Willette, Bob. And the article was included in ACS Medicinal Chemistry Letters in 2018.Safety of 7-Methoxybenzofuran-2-carboxylic acid This article mentions the following:

Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. A novel class of reverse hydroxamate BMP1 inhibitors was discovered, and cocrystal structures with BMP1 were obtained. The observed binding mode is unique in that the small mol. occupies the nonprime side of the metalloprotease pocket providing an opportunity to build in metalloprotease selectivity. Structure-guided modification of the initial hit led to the identification of an oral in vivo tool compound with selectivity over other metalloproteases. Due to irreversible inhibition of cytochrome P 450 3A4 for this chem. class, the risk of potential drug-drug interactions was managed by optimizing the series for s.c. injection. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Safety of 7-Methoxybenzofuran-2-carboxylic acid).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 7-Methoxybenzofuran-2-carboxylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones was written by Yohda, Masaaki;Yamamoto, Yasunori. And the article was included in Organic & Biomolecular Chemistry in 2015.Recommanded Product: 54120-64-8 This article mentions the following:

A series of chiral 3-aryl-isobenzofuranones I (R = 5-CF₃, 6-Br, 7-CH₃, etc.; Ar = Ph, 2-naphthyl, 3-thienyl, etc.) were synthesized via ruthenium/Me-BIPAM-catalyzed asym. addition of arylboronic acids ArB(OH)₂ to Me 2-formylbenzoates R¹C(O)H [R¹ = 2-C(O)OCH₃-C₆H₄, 2-C(O)OCH₃-5-CF₃-C₆H₃, 2-C(O)OCH₃-4-Cl-C₆H₃, etc.]. The [RuCl₂ (p-cymene)]₂/Me-BIPAM and RuCl₂(PPh₃)₃/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Recommanded Product: 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Carbene-Catalyzed Three-Component Cascade Reaction of Benzofuran-2-ones and Enals: Construction of Spirobenzofuranone-δ-lactones was written by Wang, Zhan-Yong;Shen, Fumin;Yang, Ting;Zhang, Jun-Kai;Chen, Rongxiang;Wang, Kai-Kai;Liu, Hongxin. And the article was included in Asian Journal of Organic Chemistry in 2021.Safety of 5-Nitrobenzofuran-2(3H)-one This article mentions the following:

A convenient method was developed via an NHC mediated three-component cascade reaction for the construction of medicinally important spirobenzofuranone derivatives such as I [R¹ = H, Br, NO₂; R² = Ph, 2-furyl, 1-naphthyl, etc.]. The reaction features mild reaction conditions and generates three consecutive stereocenters, one of which is an all-carbon substitution. The protocol can accommodate various substituents and substitution patterns, afford the products in moderate to good yields with excellent diastereoselectivities and moderate enantioselectivity. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9Safety of 5-Nitrobenzofuran-2(3H)-one).

5-Nitrobenzofuran-2(3H)-one (cas: 21997-23-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 5-Nitrobenzofuran-2(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem