Tag: 165.1461

Iridium(III)-bis(imidazolinyl)phenyl catalysts for enantioselective C-H functionalization with ethyl diazoacetate was written by Weldy, N. Mace;Schafer, A. G.;Owens, C. P.;Herting, C. J.;Varela-Alvarez, A.;Chen, S.;Niemeyer, Z.;Musaev, D. G.;Sigman, M. S.;Davies, H. M. L.;Blakey, S. B.. And the article was included in Chemical Science in 2016.Product Details of 52771-99-0 This article mentions the following:

The intermol. enantioselective C-H functionalization with acceptor-only metallocarbenes is reported using a new family of Ir(III)-bis(imidazolinyl)phenyl catalysts, developed based on the interplay of exptl. and computational insights. The reaction is tolerant of a variety of diazoacetate ROC(O)CH=N₂ (R = CH₂CH₃, CH₂CCl₃, C₆H₅, etc.) precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalans I [R¹ = 7-OCH₃, 4-Br, 5-(pyrrolidin-1-yl), etc.] and dihydrofurans II (R² = H, C₆H₅, CH₂C₆H₅) are functionalized in good yields and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Product Details of 52771-99-0).

5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 52771-99-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nature of the α,ω-rearrangement was written by Barton, Derek H. R.;Prabhakar, Sundaresan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 1974.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran This article mentions the following:

The conditions under which groups attached to the α-and ω-C atoms of organic compounds may exchange places were investigated. Pyrolysis of halo-O-thiobenzoates, e.g. I, bis (O-thiobenzoates), e.g. PhC(S)O(CH2)2OC(S)Ph and bis(imidates) e.g.PhC(:NPh)O(CH2)2OC(:NPh)Ph, resulted in such rearrangement. E.g., 1,2-(RCH2)(R1CH2)C6H3NO2-4 [I; R = PhC (S)O, R1 = Cl] at 160° for 3 hr gave I (R = Cl, R1 = SBz). Some of the rearrangements were shown to be intermol. and ionic in character. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran).

5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nature of the α,ω-rearrangement was written by Barton, Derek H. R.;Prabhakar, Sundaresan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 1974.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran This article mentions the following:

The conditions under which groups attached to the α-and ω-C atoms of organic compounds may exchange places were investigated. Pyrolysis of halo-O-thiobenzoates, e.g. I, bis (O-thiobenzoates), e.g. PhC(S)O(CH2)2OC(S)Ph and bis(imidates) e.g.PhC(:NPh)O(CH2)2OC(:NPh)Ph, resulted in such rearrangement. E.g., 1,2-(RCH2)(R1CH2)C6H3NO2-4 [I; R = PhC (S)O, R1 = Cl] at 160° for 3 hr gave I (R = Cl, R1 = SBz). Some of the rearrangements were shown to be intermol. and ionic in character. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran).

5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem