Site-Selective Functionalization of (sp3)C-H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor was written by Gu, Yang;Natoli, Sean N.;Liu, Zhennan;Clark, Douglas S.;Hartwig, John F.. And the article was included in Angewandte Chemie, International Edition in 2019.Computed Properties of C8H7NO3 This article mentions the following:
The selective functionalization of one C-H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex mols. We report site-selective functionalizations of C-H bonds, differentiated solely by remote substituents, catalyzed by artificial metalloenzymes (ArMs) that are generated from the combination of an evolvable P 450 scaffold and an iridium-porphyrin cofactor. The generated systems catalyze the insertion of carbenes into the C-H bonds of a range of phthalan derivatives containing substituents that render the two methylene positions in each phthalan inequivalent. These reactions occur with site-selectivity ratios of up to 17.8:1 and, in most cases, with pairs of enzyme mutants that preferentially form each of the two constitutional isomers. This study demonstrates the potential of abiotic reactions catalyzed by metalloenzymes to functionalize C-H bonds with site selectivity that is difficult to achieve with small-mol. catalysts. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Computed Properties of C8H7NO3).
5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C8H7NO3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem