Nature of the α,ω-rearrangement was written by Barton, Derek H. R.;Prabhakar, Sundaresan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 1974.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran This article mentions the following:
The conditions under which groups attached to the α-and ω-C atoms of organic compounds may exchange places were investigated. Pyrolysis of halo-O-thiobenzoates, e.g. I, bis (O-thiobenzoates), e.g. PhC(S)O(CH2)2OC(S)Ph and bis(imidates) e.g.PhC(:NPh)O(CH2)2OC(:NPh)Ph, resulted in such rearrangement. E.g., 1,2-(RCH2)(R1CH2)C6H3NO2-4 [I; R = PhC (S)O, R1 = Cl] at 160° for 3 hr gave I (R = Cl, R1 = SBz). Some of the rearrangements were shown to be intermol. and ionic in character. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran).
5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 5-Nitro-1,3-dihydroisobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem