Iridium(III)-bis(imidazolinyl)phenyl catalysts for enantioselective C-H functionalization with ethyl diazoacetate was written by Weldy, N. Mace;Schafer, A. G.;Owens, C. P.;Herting, C. J.;Varela-Alvarez, A.;Chen, S.;Niemeyer, Z.;Musaev, D. G.;Sigman, M. S.;Davies, H. M. L.;Blakey, S. B.. And the article was included in Chemical Science in 2016.Product Details of 52771-99-0 This article mentions the following:
The intermol. enantioselective C-H functionalization with acceptor-only metallocarbenes is reported using a new family of Ir(III)-bis(imidazolinyl)phenyl catalysts, developed based on the interplay of exptl. and computational insights. The reaction is tolerant of a variety of diazoacetate ROC(O)CH=N2 (R = CH2CH3, CH2CCl3, C6H5, etc.) precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalans I [R1 = 7-OCH3, 4-Br, 5-(pyrrolidin-1-yl), etc.] and dihydrofurans II (R2 = H, C6H5, CH2C6H5) are functionalized in good yields and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Product Details of 52771-99-0).
5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 52771-99-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem