Tag: M.W:200-300

19477-73-7, 6-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10196] 3,6-Dibromoisobenzofuran-1(3H)-one (21a) In a SOmE round bottom flask was added 6-bromoisobenzothran- 1(3H)-one (1.00 g, 4.69 mmol), N-bromosuccinimide (958 mg, 5.38 mmol), 2,2?-azobis(2-methylpropionitrile) (75 mg, 0.46 mmol), and chloroform (23 mE). The mixture was refluxed for 2.5 hours, then cooled to room temperature and quenched with sat. aq. NaHCO3 (25 mE). The organic layer was removed, washed with water (20 mE), washed with brine (15 mE), and concentrated on to silica. The crude product was purified by flash column chromatography using a gradient of 5-10% ethyl acetate in hexanes to yield 21 a as a white solid in61% yield. ?H NMR (500 MHz, CDC13) oe 8.06 (d, J=1 .5 Hz, 1H), 7.90 (dd, J=8.1, 1.7 Hz, 1H), 7.52 (d, J=8.3 Hz, 1H), 7.37 (s, 1H). ECMS does not ionize.

19477-73-7, The synthetic route of 19477-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Northeastern University; POLLASTRI, Michael P.; MEHTA, Naimee; DEVINE, William; WOODRING, Jennifer; SWAMINATHAN, Uma; US2015/259331; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120973-72-0,2-Benzoylbenzofuran-5-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 1 (100 mg, 0.56 mmol) and 4-(dimethylamino)benzaldehyde (2a) (83 mg, 0.56 mmol) in dry 1,4 dioxane was added gradually BF3¡¤OEt2 (0.142 mL, 1.12 mmol) at room temperature. The whole reaction mixture was stirred for 24 h. The reaction mixture was then diluted with ethyl acetate (100 mL) and washed with water (3 x 25 mL) to decompose the BF3¡¤OEt2 complex. The organic solution obtained after extraction was dried over anhyd. Na2SO4, filtered and the solvent was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane-ethyl acetate (93:7) as a mobile phase to afford 3a. (140 mg, 80%),, 120973-72-0

120973-72-0 2-Benzoylbenzofuran-5-carbaldehyde 2794865, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Narender; Venkateswarlu; Nayak, B. Vishnu; Sarkar; Tetrahedron Letters; vol. 52; 44; (2011); p. 5794 – 5798;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

4.1.38 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione (7l) A mixture of 5-(tert-butyl)isobenzofuran-1,3-dione (93 mg, 0.5 mmol), 3-bromo-2-methylaniline (100 mg, 0.5 mmol) in AcOH (2 mL) was stirred at 100 C for 2 h. The reaction mixture was cooled down to room temperature and diluted with water (10 mL), and then the NaHCO3 solution was added. The product was extracted three times with EtOAc (30 mL) and the combined organic layer was dried over Na2SO4. The solvent was removed in vacuo and the residue product was purified on a silica gel column using petroleum ether/EtOAc (4:1, v/v) as eluent to afford 7l (83 mg, 45.2%) as a gray solid. MS (ESI) m/z 372.1 [M+H]+; 1H NMR (400 MHz, DMSO-d6): delta 7.97-7.95 (m, 1H), 8.42 (s, 1H), 7.93-7.91 (d, J = 8.60 Hz, 1H), 7.77-7.75 (d, J = 8.00 Hz, 1H), 7.44-7.43 (d, J = 7.72 Hz, 1H), 7.33-7.29 (t, J = 15.90 Hz, 1H), 2.17 (s, 3H), 1.38 (s, 9H)., 32703-79-0

32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Xinge; Xin, Minhang; Huang, Wei; Ren, Yanliang; Jin, Qiu; Tang, Feng; Jiang, Hailong; Wang, Yazhou; Yang, Jie; Mo, Shifu; Xiang, Hua; Bioorganic and Medicinal Chemistry; vol. 23; 2; (2015); p. 348 – 364;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69604-00-8,Ethyl 5-nitrobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

69604-00-8, 2N sodium hydroxide solution (15.62 mL) was added dropwise to a solution of compound 10 (2.35 g, 10 mmol) and methanol (32 mL), The reaction solution began to cloud, gradually clear, the reaction for half an hour, the concentrated hydrochloric acid added to the reaction solution,The pH was adjusted to 1 and then extracted with ethyl acetate. The organic phase was dried and concentrated to give 1.69 g of a yellow solid as Compound 11 in a yield of 82%.

The synthetic route of 69604-00-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Luoyang Juhui Pharmaceutical Technology Co., Ltd.; Zhang Hongli; Yang Songfeng; (36 pag.)CN106749203; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1; Preparation of 3-iodo-N,N-diethylphthalamidic acid . To 15 ml of an acetonitrile solution containing 2.0 g of 3-iodophthalic anhydride was added dropwise 0.7 g of diethylamine under ice-cooling and stirring, and after completion of the dropwise addition, the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the precipitated solid were collected by filtration, washed with a small amount of acetonitrile to obtain 1.5 g of the objective material as pale yellowish crystals. Melting point 120.0 to 122.0C1H NMR (CDCl3, Me4Si, 300MHz) delta 8.28 (bs, 1 H), 8.05 (d, J=8.5Hz, 1 H), 7.98 (d, J=8.5Hz, 1 H), 7.0-7.2 (m, 1 H), 3.67 (q, J=7.2Hz, 2H), 3.49 (q, J=7.2Hz, 2H), 1.12 (t, J=7.2Hz, 3H), 1.10 (t, J=7.2Hz, 3H).

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES, LIMITED; EP1538138; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

123654-26-2, 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylic acid (Chem. Pharm. Bull. 1998, 46{), 42-52; 3.93 g, 18.4 mmol) in methanol (36.8 mL), cooled at 0 C, thionyl chloride (6.0 mL) was added. The reaction mixture was gradually warmed to room temperature and was heated to reflux for 2 hours. The volatiles were removed under reduced pressure; the crude mass was diluted with aqueous sodium bicarbonate solution and was extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulphate and the solvent was removed under vacuum to obtain methyl 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylate (3.89 grams). Yield: 92.9 % ? – NMR (DMSO-de): delta 7.43 (s, 1H), 6.06 (bs, 2H), 4.60 (t, J = 8.8 Hz, 2H), 3.68 (s, 3H), 2.97 (t, J = 8.8 Hz, 2H); Mass (m/z): 228.0, 230.1 (M+H)+.

123654-26-2, The synthetic route of 123654-26-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul Rasheed; YARLGADDA, Suresh; RAVELLA, Srinivasa Rao; SHINDE, Anil Karbhari; KAMBHAMPATI, Ramasastri; ROAYALLEY, Praveen Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; PATNALA, Sriramachandra Murthy; RAVULA, Jyothsna; JASTI, Venkateswarlu; WO2013/42135; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

115010-11-2, 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 47 Preparation of N-[2R-hydroxy-3-[[(2,3-dihydrobenzofuran-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-2S-[[(pyrrolidino)acetyl]amino]-3,3-dimethylbutanamide STR92 N-[2R-hydroxy-3-[[(1,1-dimethylethoxy)carbonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-2S-[[(pyrrolidin-1-yl)acetyl]amino]-3,3-dimethylbutanamide (2 g, 3.57 mmol) in Dioxane/HCl (4N, 10 mL) was stirred for 2 hours at room temperature. The solvent was removed and the residue was dried in vacuo. The residue was stirred in ethyl acetate (50 mL) then 2,3-dihydro benzofuran-5-ylsulfonyl chloride (0.737 g, 3.57 mmol) was added followed by triethylamine (1.587 g, 15.71 mmol) and the mixture was stirred for 18 hours at room temperature. The reaction mixture was diluted with ethyl acetate (100 mL), washed with saturated sodium bicarbonate (saturated, 100 mL) and brine (100 mL), dried (MgSO4), and concentrated. The residue was chromatographed in ethyl acetate to afford the desired product as a white powder.

115010-11-2, The synthetic route of 115010-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G.D. Searle & Co.; US5756533; (1998); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A 500 mL RB flask was charged with aluminum (III) chloride (4.1 g, 31 mmol) and 10 mL of 1, 2-dichloroethane (90 ml, 1142 mmol) , then cooled to 00C. A separate 250 mL flask was charged with 90 mL of 1, 2-dichloroethane (90 ml, 1142 mmol) and cooled to 00C; methylamine (gas) (1.8 g, 59 mmol) was bubbled through the solution for 10 minutes. The dichloroethane solution was slowly poured into the aluminum chloride solution, resulting in the formation of a thick white slush. This was warmed to room temperature. 5-bromoisobenzofuran-1 (3H) -one (5.00 g, 23 mmol) was added in one portion and the reaction mixture was stirred for 2.5 hours and quenched with water. The mixture was filtered to remove the solid impurities, then the filtrate was washed with 0.5N aqueous HCl (100 mL) and brine (200 mL) . The organic layer was dried with MgSO4, filtered, and concentrated to give a white solid. This was triturated with EtOAc and filtered to give 4-bromo-2- (hydroxymethyl) -N-methylbenzamide (3.34 g, 58% yield) as a white solid., 64169-34-2

The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2008/8539; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

763114-25-6, 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

763114-25-6, Step 50.2: Synthesis of 2-Fluoro-5-[(4-oxo-3H-phthalazin-l-yl)methyl]benzoic Acid (5.2).[0242] As such, to a stirred suspension of 50.1 (-10 mmol) in water (20 mL) was added aqueous NaOH (10 N, 5 mL). The reaction was subsequently heated to 100 C for 1 h. After the reaction mixture was cooled to roughly 70 C and hydrazine hydrate (5.0 mL, 100 mmol) was added. The mixture was stirred at 70 C for 24 h. The reaction was cooled room temperature and acidified with HC1 (8 N, ca. 80 mL) to pH 4. After reaction was again cooled to room temperature, the solid was collected with filtration, washed with water (10 mL), ether (3 x 10 mL) and was dried to produce compound 50.2 (2.41 g) as a white solid. MS (ESI+) m/z = 299 (M+H).

As the paragraph descriping shows that 763114-25-6 is playing an increasingly important role.

Reference£º
Patent; NEWGEN THERAPEUTICS, INC.; SHEN, Wang; MAUNG, Jack; ZHANG, Aimin; ZHENG, Xiaoling; WO2012/166983; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Example 9:Preparation of darifenacin hydrochloride:To 3-(S)-(+)-(l-carbamoyl-l,l-diphenyl methyl) pyrrolidine tartrate (100 grams) taken in water (500 ml), a solution of aqueous sodium hydroxide was added till the pH reached 14. The reaction mixture was stirred for 20 min at 25-300C, sodium chloride(150 grams) was added to it and stirred further for 20min. The reaction mixture was heated to 55-600C and extracted with toluene. The toluene layer was washed with 5percent sodium chloride solution and the solvent distilled off under reduced pressure. The residue was dissolved in acetonitrile, 5-(2-bromoethyl) 2,3-dihydrobenzofuran (66 grams dissolved in 800 ml acetonitrile) and potassium hydroxide (13 grams) was added to it.The reaction mixture was heated to 40-500C and stirred for 18 hrs. The reaction mixture was cooled to 25-30¡ãC and filtered. The acetonitrile solvent was distilled off under reduced pressure. The residue was dissolved in acetone, cooled to 0-5 ¡ãC and hydrochloric acid (36 ml) was added to it. The temperature was raised to 25-30¡ãC and stirred for 12 hrs. The reaction mixture was cooled to 0-5¡ã C, the solid obtained was filtered, washed with acetone and dried. It was purified using methanol and acetone to provide the title compound as a white solid. Yield: 75 grams Example 11:Preparation of darifenacin hydrobromide:To 3 -(S)-(+)-(l -carbamoyl -1,1 diphenyl methyl) pyrrolidine tartrate (100 grams) taken in water (500 ml), a solution of aqueous sodium hydroxide was added till the pH reached 14. The reaction mixture was stirred for 20 min at 25-30¡ãC and sodium chloride(150 grams) was added to it and stirred for 20min. The reaction mixture was heated to55-6O0C and extracted with toluene. The toluene layer was washed with 5percent sodium chloride solution and the solvent distilled off under reduced pressure. The residue was dissolved in acetonitrile, 5-(2-bromoethyl)-2,3-dihydrobenzofuran (66 grams dissolved in 800 ml acetonitrile) and potassium hydroxide (13 grams) was added to it. The reaction mixture was heated to 40-50¡ãC and stirred for 18 hrs. The reaction mixture was cooled to 25-30¡ãC and filtered. The acetonitrile solvent was distilled off under reduced pressure. The residue was dissolved in acetone, cooled to 0-5¡ãC and hydrobromic acid (36 ml) was added to it. The temperature was raised to 25-30¡ãC and stirred for 12 hrs. The reaction mixture was cooled to 0-5¡ã C, the solid obtained was filtered, washed with acetone and dried. It was purified using methanol and acetone to provide the title compound as a white solid.Yield: 75 gramsSOR: +45 (C=I, dichloromethane)

127264-14-6, The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem