With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
4.1.38 2-(3-Bromo-2-methylphenyl)-5-(tert-butyl)isoindoline-1,3-dione (7l) A mixture of 5-(tert-butyl)isobenzofuran-1,3-dione (93 mg, 0.5 mmol), 3-bromo-2-methylaniline (100 mg, 0.5 mmol) in AcOH (2 mL) was stirred at 100 C for 2 h. The reaction mixture was cooled down to room temperature and diluted with water (10 mL), and then the NaHCO3 solution was added. The product was extracted three times with EtOAc (30 mL) and the combined organic layer was dried over Na2SO4. The solvent was removed in vacuo and the residue product was purified on a silica gel column using petroleum ether/EtOAc (4:1, v/v) as eluent to afford 7l (83 mg, 45.2%) as a gray solid. MS (ESI) m/z 372.1 [M+H]+; 1H NMR (400 MHz, DMSO-d6): delta 7.97-7.95 (m, 1H), 8.42 (s, 1H), 7.93-7.91 (d, J = 8.60 Hz, 1H), 7.77-7.75 (d, J = 8.00 Hz, 1H), 7.44-7.43 (d, J = 7.72 Hz, 1H), 7.33-7.29 (t, J = 15.90 Hz, 1H), 2.17 (s, 3H), 1.38 (s, 9H)., 32703-79-0
32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Article; Zhao, Xinge; Xin, Minhang; Huang, Wei; Ren, Yanliang; Jin, Qiu; Tang, Feng; Jiang, Hailong; Wang, Yazhou; Yang, Jie; Mo, Shifu; Xiang, Hua; Bioorganic and Medicinal Chemistry; vol. 23; 2; (2015); p. 348 – 364;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem