Analyzing the synthesis route of 123654-26-2

123654-26-2, The synthetic route of 123654-26-2 has been constantly updated, and we look forward to future research findings.

123654-26-2, 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylic acid (Chem. Pharm. Bull. 1998, 46{), 42-52; 3.93 g, 18.4 mmol) in methanol (36.8 mL), cooled at 0 C, thionyl chloride (6.0 mL) was added. The reaction mixture was gradually warmed to room temperature and was heated to reflux for 2 hours. The volatiles were removed under reduced pressure; the crude mass was diluted with aqueous sodium bicarbonate solution and was extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulphate and the solvent was removed under vacuum to obtain methyl 4-amino-5-chloro-2,3-dihydro benzofuran-7-carboxylate (3.89 grams). Yield: 92.9 % ? – NMR (DMSO-de): delta 7.43 (s, 1H), 6.06 (bs, 2H), 4.60 (t, J = 8.8 Hz, 2H), 3.68 (s, 3H), 2.97 (t, J = 8.8 Hz, 2H); Mass (m/z): 228.0, 230.1 (M+H)+.

123654-26-2, The synthetic route of 123654-26-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul Rasheed; YARLGADDA, Suresh; RAVELLA, Srinivasa Rao; SHINDE, Anil Karbhari; KAMBHAMPATI, Ramasastri; ROAYALLEY, Praveen Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; PATNALA, Sriramachandra Murthy; RAVULA, Jyothsna; JASTI, Venkateswarlu; WO2013/42135; (2013); A1;,
Benzofuran – Wikipedia
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