19477-73-7, 6-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10196] 3,6-Dibromoisobenzofuran-1(3H)-one (21a) In a SOmE round bottom flask was added 6-bromoisobenzothran- 1(3H)-one (1.00 g, 4.69 mmol), N-bromosuccinimide (958 mg, 5.38 mmol), 2,2?-azobis(2-methylpropionitrile) (75 mg, 0.46 mmol), and chloroform (23 mE). The mixture was refluxed for 2.5 hours, then cooled to room temperature and quenched with sat. aq. NaHCO3 (25 mE). The organic layer was removed, washed with water (20 mE), washed with brine (15 mE), and concentrated on to silica. The crude product was purified by flash column chromatography using a gradient of 5-10% ethyl acetate in hexanes to yield 21 a as a white solid in61% yield. ?H NMR (500 MHz, CDC13) oe 8.06 (d, J=1 .5 Hz, 1H), 7.90 (dd, J=8.1, 1.7 Hz, 1H), 7.52 (d, J=8.3 Hz, 1H), 7.37 (s, 1H). ECMS does not ionize.
19477-73-7, The synthetic route of 19477-73-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Northeastern University; POLLASTRI, Michael P.; MEHTA, Naimee; DEVINE, William; WOODRING, Jennifer; SWAMINATHAN, Uma; US2015/259331; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem