Tag: M.W:200-300

19477-73-7, 6-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Bromophthalide was prepared by portion wise addition of phthalide (1 g, 7.45 mmol) to a mixture of trifluoroacetic acid (TFA) (3.7 mL) and sulfuric acid (1.7 mL) at room temperature for 9 h. The reaction mixturewas stirred at room temperature for 60 h, then poured onto ice and extracted with ethyl acetate. The combined organic phases were subsequently washed with a saturated solution of sodium bicarbonate and brine. After evaporation of the solvents in vacuum, the crude product was purified by column chromatography on silica gel (n-hexane/EtOAc: 9/1) to yield the desired product, 19477-73-7

19477-73-7 6-Bromoisobenzofuran-1(3H)-one 262235, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Mirabdolbaghi, Roya; Dudding, Travis; Tetrahedron; vol. 69; 15; (2013); p. 3287 – 3292;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

(3-1). Production of 3-iodo-N-(4-heptafluoroisopropyl-2-methylphenyl)phthalimide To a suspension of 2.7 g of 3-iodophthalic anhydride in 30 ml of acetic acid was added 2.7 g of 4-heptafluoroisopropyl-2-methylaniline, and the resulting mixture was heated under reflux for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure from the reaction mixture, and the resulting residue was purified by silica gel column chromatography to obtain 4.8 g of the desired compound. Yield: 89%.

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Nihon Nohyaku Co., Ltd.; EP1241159; (2002); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

253429-31-1, 7-Bromo-4-fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 57 A mixture of 7-bromo-4-fluoro-1-benzofuran (5.30 g), zinc cyanide (1.74 g), tetrakis(triphenylphosphine)palladium(0) (2.85 g), and N,N-dimethylformamide (160 mL) was stirred at 100C for 2.5 hours under argon atmosphere. After cooling to room temperature, the reactant was poured into water and extracted with ethyl acetate. Insolubles were filtered off using celite. The organic layer was washed with brine, dried and concentrated. The obtained residue was purified by silica gel column chromatography to obtain 4-fluoro-1-benzofuran-7-carbonitrile (3.63 g). 1H-NMR (300 MHz, CDCl3) delta: 6.96 (1H, d, J=2.4 Hz), 7.03 (1H, d, J=8.7 Hz), 7.60 (1H, dd, J=8.7 and 5.1 Hz), 7.74 (1H, d, J=2.4 Hz). IR (KBr) 2232, 1497, 1271 cm-1, 253429-31-1

As the paragraph descriping shows that 253429-31-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1553074; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product., 6940-49-4

As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

550998-59-9, 7-Bromobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

550998-59-9, 4.0 g [(16.] 59 mmol) [7-BROMBENZOFURAN-2-CARBONSaeURE] (Beispiel 29A), 3.3 g (16.59 mmol) [(S)-3-AMINOCHINUKLIDIN-DIHYDROCHLORID,] 7.57 g (19.91 mmol) HATU, 10.41 mL (59.74 mmol) N, N-Diisopropylethylamin und [21] mL DMF werden gemaess der allgemeinen Arbeitsvorschrift C umgesetzt. Das Solvens wird unter reduziertem Druck entfernt, das Rohprodukt in 100 mL Essigsaeureethylester aufgenommen und 15-mal mit insgesamt 1.5 L 1 N Natronlauge gewaschen. Die organische Phase wird ueber Magnesiumsulfat getrocknet und vom Solvens befreit. Es werden 5.0 g [(85] % d. Th. ) der Titelverbindung isoliert. Die analytischen Daten stimmen mit denen aus Beispiel 30A ueberein. [alpha20 D] =-28. [0] (c = 0.1, Methanol).

The synthetic route of 550998-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123654-26-2,4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

a) A mixture of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid (4.3 g) in thionyl chloride (100 ml) and CHCl3 (200 ml) was stirred and refluxed for 2 hours. The mixture was cooled and the solvent was evaporated. Toluene was added and evaporated again, yielding 4.8 g of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarbonyl chloride (100% crude residue) (intermediate 7).

123654-26-2, The synthetic route of 123654-26-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Janssen Pharmaceutica, N.V.; US5872131; (1999); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

Method 0 : 4-bromo-2- (hydroxymethyl) -N- (2,2,2- trifluoroethyl) benzamide; [00134] To a stirred suspension of aluminium trichloride (4.07 g, 30.5 mmol) in dichloroethane (60 ml) cooled to 5C under a nitrogen atmosphere was added the solution of trifluoroethylamine (5.84 g, 38.7 mmol) at such a rate to keep the temperature of the reaction mixture below 100C. After complete addition the reaction mixture was allowed to warm up to room temperature and stirred at this temperature for 4 hours. After this time bromophthalide powder (5 g, 23.5 mmol) was added in one portion and the reaction mixture was then heated to 800C for 18 hours. TLC showed complete conversion from starting material to product and the reaction was carefully quenched with iced water (100 ml) and stirred for 30 minutes until all the ice melted. Dichloromethane was added and the mixture was filtered through a pad of silica and washed with copious amounts of DCM to remove the aluminium residues. The filtrate was separated and the aqueous layer was further extracted with DCM (2 x 100 ml) . The organic layers were combined and dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound as an off-white powder (3.37 g, 46% yield) . 1H NMR (DMSO D6, 400 MHz) 4.02-4.11 (2H, m) , 4.60-4.61 (2H, m) , 5.43- 5.46 (H, m) , 7.36-7.39 (H, d) , 7.55-7.57 (H, m) , 7.76 (H, s) and 9.09-9.12 (H, m) ; MS (ES+) 312, (ES”) 310., 64169-34-2

The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/128009; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Preparation 28 Preparation of N-{2-(2,3-dihydrobenzofuran-5-yl)ethyl}methylamine A solution of 5-(2-bromoethyl)-2,3-dihydrobenzofuran (1.5 g – see Preparation 20) in 33percent methylamine in methanol (40 ml) was heated at 100¡ãC in a stainless steel pressure vessel for 6 hours then concentrated in vacuo . The residue was partitioned between dichloromethane (50 ml) and 10percent aqueous sodium carbonate (50 ml). The layers where separated and the aqueous layer was further extracted with dichloromethane (2 * 50 ml). The aqueous layer was concentrated in vacuo to give a solid which was triturated with boiling 2-propanol. The mixture was filtered and the filtrate concentrated in vacuo to give a solid which was purified by column chromatography on silica eluding with dichloromethane containing methanol (0percent up to 1percent). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless solid, yield, 0.31 g, m.p. 153-155¡ãC. 1H N.m.r. (CDCl3) delta = 9.80-9.60 (brs, 1H), 7.10 (s, 1H), 7.00-6.95 (d, 1H), 6.75-6.70 (d, 1H), 4.60-4.50 (t, 2H), 3.30-3.10 (m, 6H), 2.75 (s, 3H) ppm., 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Limited; PFIZER INC.; EP364123; (1991); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

To the beaker 1 was added 10.0 g of 1.1-dimethyl-2-methylthioethylamine (0.084 mol) and 15.6 g at 20-35 C.Acetone; 17.7 g of 3-iodophthalic anhydride (0.065 mol) and 70 g of acetone were added to beaker 2, and stirred with a glass rod for 5 minutes.After the clock, the solid is completely dissolved; in the beaker 1, the liquid A is pumped into the mixer by the mechanical pump A, and at the same time, the liquid B in the beaker 2 is also used by the mechanical pump B.Pumped into the mixer, the flow ratio of mechanical pump A to mechanical pump B is 1:3.43 (mass ratio), and the liquid in the mixer enters the operation.In a microchannel reactor with a temperature of 8 C, the retention time in the microchannel reactor was 10 minutes, and the cone was received and discharged.The reaction solution was evaporated under reduced pressure to give a pale yellow solid: 24.3 g, yield: 95.7% (3-iodophthalic anhydrideThe main product content is: 96% (HPLC), the isomer content is 2.6% (HPLC),, 28418-88-4

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Liu Zuhe; Yao Yuan; Lu Wenlong; Cao Li; (7 pag.)CN109574892; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem