Tag: M.W:200-300

652-12-0, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Makhseed, Saad, mentioned the application of 652-12-0, Name is Tetrafluorophthalic anhydride, molecular formula is C8F4O3

Phthalimide based polymers of intrinsic microporosity

A series of phthalimide based microporous polymers were successfully prepared by conventional nucleophilic substitution reaction of several newly synthesized fluoro-monomers with commercially available 5,5?,6,6?- tetrahydroxy-3,3,3?,3?-tetramethylspirobisindane. FTIR, 1H NMR, and elemental analyses were used to identify the proposed structures of the polymers. The synthesized polymers are of high molecular weight as demonstrated by Gel Permeation Chromatography (GPC). Thermogravimetric analysis shows that the prepared polymers were stable up to 300C. From the porosity analysis it is clear that the prepared polymers are analogous to polymers of intrinsic microporosity (PIMs) with high surface area (500-900 m2/g). The t-plot analysis shown that the major contribution to the specific surface area is arising from the micropore surface area with narrow size distribution of ultramicropores as confirmed by the Horvath-Kawazoe (H-K) analysis. The hydrogen storage capacity of the prepared PIM-R(1-7) and CO-PIM(3,4,6,7) were promising (up to 1.26 wt%, 77 K, at 1.13 bar) with high isoteric heats of H2 adsorption (8.5 kJ/mol).The results of this study demonstrate that controlling the appropriate monomer content via the three-dimensional structure can provide a uniform microporous morphology in the target polymers.

652-12-0, Interested yet? Read on for other articles about 652-12-0!

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Benzofuran – Wikipedia,
Benzofuran | C8H3735O – PubChem

19477-73-7, 6-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tris(dibenzylideneacetone)dipalladium (0) (30 mg, 0.033 mmol), tri-o-tolylphosphine (40 mg, 0.13 mmol), and tetramethyltin (600 mg, 3.35 mmol) were dissolved in hexamethylphosphoramide (0.6 ml), and 6-bromo-1(3H)-isobenzofuranone (144 mg, 0.676 mmol) obtained from Example 26-(2) was added thereto, then the mixture was heated at 50C for 2 hours. After cooling the reaction mixture, the mixture was diluted with ethyl acetate, and washed successively twice with water and twice with an aqueous solution of sodium chloride. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was subjected to chromatography on a silica gel (5 g) column (eluent; hexane : ethyl acetate = 3 : 1). The fractions containing the target compound were concentrated, and the obtained solid was recrystallized to afford the title compound (88.3 mg, 88% yield) as a crystalline solid. NMR spectrum (400 MHz, CDCl3) delta ppm: 2.472 (3H, s), 5.284 (2H, s), 7.376 (1H, d, J=8 Hz), 7.497 (1H, d, J=8 Hz), 7.721 (1H, s)., 19477-73-7

The synthetic route of 19477-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sankyo Company, Limited; EP1362856; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of the bromo methyl seco compound prepared in step A in DMF was added EDC (10mg, 0.054mMoles) and 5-Nitro benzofuran carboxylic acid (12mg, 0.054 mMoles) and allowed to stir for 6 hours. To this reaction mixture was then added ethyl acetate and brine. The combined organic layers were concentrated after three extractions with ethyl acetate. And filterd over silica gel using MeOH/DCM with increasing amounts of MeOH The product was confirmed by Mass Spec, M+1 = 530, 10242-12-3

As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; MEDAREX, INC.; WO2005/112919; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69604-00-8,Ethyl 5-nitrobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

69604-00-8, Ethyl 2-nitrobenzofuran-2-carboxylate (23.5 g) prepared according to Example 4 was added to a reaction flask, 200 ml of ethanol was added, 3 g of 5% palladium carbon was added, and the mixture was replaced with hydrogen 3 times.The hydrogen pressure was controlled to be 0.4-0.5 MPa, hydrogenation reaction was performed at 30 C. for 3 hours, the reaction was completed, and the reaction was filtered. The filtrate was concentrated under reduced pressure to dryness to obtain 19.5 g of 5-aminobenzofuran-2-carboxylic acid ethyl ester.Yield 95.1%, purity 98.8%.

69604-00-8 Ethyl 5-nitrobenzofuran-2-carboxylate 1382954, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Lianyungang Hengyun Pharmaceutical Co., Ltd.; Dong Shuqiu; Feng Ruimao; Zhang Qingjie; (8 pag.)CN107540646; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.1.20 5,6-Dichlorophthalide (41) Anhydride 40 (9.53 g, 42.6 mmol) was dissolved with stirring in THF (80 mL) and the solution was cooled to 0 ¡ãC under an Ar atmosphere. NaBH4 (1.63 g, 43.1 mmol) was added slowly in a single portion, and the mixture was stirred with cooling to 0 ¡ãC for 50 min. The mixture was removed from the ice-water bath and warmed to room temperature for 17 h. MeOH (20 mL) was added slowly and cautiously to the obtained suspension. The mixture was concentrated in vacuo. Dilute, aqueous HCl (0.1 M, 24 mL) was added to the residue. After stirring the mixture for 10 min, it was filtered. The collected solids were vigorously heated at reflux in PhMe (100 mL) with pTsOH¡¤H2O (0.15 g), using a Dean-Stark trap to collect H2O, for 30 h 15 min. The mixture was concentrated in vacuo. The residue was washed with H2O (50 mL) and the solid was azeotroped with PhMe (10 mL) and dried under high vacuum to provide 41 (6.41 g, 74percent) as a white solid, Rf (SiO2, CHCl3) 0.55: mp 157-160 ¡ãC. 1H NMR (300 MHz, DMSO-d6) delta 8.14 (s, 1H), 8.04 (s, 1H), 5.40 (s, 2H); CIMS m/z (rel intensity) 203/205/207 (MH+, 100/71/14)., 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6296-53-3,N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide,as a common compound, the synthetic route is as follows.,6296-53-3

A stirred mixture of 5-amino-5-(3-ethoxy-4-methoxyphenyl)pentan-3-ol hydrochloride(1.15 g, 3.97 mmol), 3-acetamidophthalic anhydride (0.82 g, 3.97 mmol) and triethylamine (0.4 g, 3.97 mmol) in DMF (20 ML) was heated at 80-90¡ã C. for 6 hours. The mixture was then concentrated in vacuo. The residue was dissolved in ethyl acetate (80 ML), washed with water (30 ML), brine (30 ML) and dried over magnesium sulfate. The solvent was removed in vacuo and the residue was purified by chromatography (silica gel, methylene chloride:ethyl acetate 8:2) to give N-{2-[1-(3-ethoxy-4-methoxyphenyl)-3-hydroxypentyl]-1,3-dioxoisoindolin-4-yl}acetamide (1.35 g, 77percent); 1H NMR (CDCl3) delta9.52 (s, 1H), 8.71 (d, J=8.4 Hz, 1H), 7.63 (t, J=7.6 Hz, 1H), 7.48 (d, J=7.3 Hz, 1H), 7.09-7.07 (m, 2H), 6.83-6.80 (m, 1H), 5.61-5.55 (J=3.9, 11.9 Hz, 1H), 4.11 (q, J=6.9 Hz, 2H), 3.84 (s, 3H), 3.47 (m, 1H), 2.97-2.86 (m, 1H), 2.25 (s, 3H), 2.06-1.95 (m, 1H), 1.78 (b, 1H), 1.62-1.52 (m, 2H), 1.45 (t, J=7.0 Hz, 3H), 0.95 (t, J=7.3 Hz, 3H); 13C NMR (CDCl3) delta170.39, 169.23, 168.11, 148.94, 148.14, 137.32, 135.83, 131.81, 131.19, 124.72, 120.30, 117.94, 115.31, 112.87, 111.09, 70.01, 64.36, 55.86, 51.29, 37.92, 30.46, 24.92, 14.73, 9.90.

6296-53-3 N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide 226121, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Celgene Corporation; US6667316; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A three-neck 5 L round bottomed flask equipped with a stir bar, firestone valve, thermocouple, condenser and heating mantle was charged with tri-t-butyl phosphonium tetrafluoroborate (500 mg, 1.72 mmol), palladium (II) acetate (250 mg, 1.1 mmol) and 5-bromo-2-benzofuran-1(3H)-one (100 g, 470 mmol). DMF (1.88 L) was added to the flask, and the mixture was degassed three times by alternating vacuum and nitrogen purge. Commercially available bromo(1,3-dioxolan-2-ylmethyl)zinc solution (1.03 L, 516 mmol) was added via cannula and the mixture was again degassed three times. The mixture was then heated at 85 C. for 5 hr. Analysis by HPLC-MS indicated the reaction was not complete. The mixture was stirred at 85 C. for 5 more h. The mixture was then cooled to return to room temperature for overnight. 2-MethylTHF (2 L) and brine were added, and the mixture was stirred for 5 min. The layers were separated and the aqueous layer was extracted again with 2-methylTHF. The organic layers were combined, washed three times with brine (4 L each), dried over MgSO4, filtered, and concentrated. The crude product was purified by flash chromatography (1.5 kg silica cartridge), eluting with 0-20% ethyl acetate in dichloromethane to afford the title compound. MS [M+H]+=221.

64169-34-2, 64169-34-2 5-Bromoisobenzofuran-1(3H)-one 603144, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; Biswas, Dipshikha; Ding, Fa-Xiang; Dong, Shuzhi; Gu, Xin; Jiang, Jinlong; Pasternak, Alexander; Suzuki, Takao; Vacca, Joseph; Xu, Shouning; (81 pag.)US2017/37037; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-benzofuran-l(3H)-one To a microwave tube containing a stir bar was added 5-bromo-2-benzofuran-l (3H)-one (0.10 g, 0.47 mmol), Bis(pinacolato)diboron (0.12 g, 0.47 mmol), bis(diphenylphosphino)palladium(II) (0.010 g, 0.014 mmol), potassium acetate (0.14 g, 1.4 mmol) and anhydrous toluene (10 mL). The resulting mixture was capped and heated at 80 C for 2 h. The reaction mixture was diluted with benzene and washed successively with water and brine. The organic layer was then dried (Na2S04), filtered, and concentrated. The resulting residue was purified by silica gel column chromatography (hexanes/EtOAc = 1/1) to provide 5- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-benzofuran-l(3H)-one. LC/MS: [(M+l)]+ =261.

64169-34-2, The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem