Tag: 200-300

Rana, Manish Kumar et al. published their research in Protein Journal in 2016 | CAS: 38183-12-9

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Multi-modal Binding of a ‘Self’ Peptide by HLA-B*27:04 and B*27:05 Allelic Variants, but not B*27:09 or B*27:06 Variants: Fresh Support for Some Theories Explaining Differential Disease Association was written by Rana, Manish Kumar;Luthra-Guptasarma, Manni. And the article was included in Protein Journal in 2016.COA of Formula: C17H10O4 This article mentions the following:

A self-derived-peptide with the same amino acid sequence (N-RRYLENGKETLQR-C) as residues 169-181 of the human leukocyte antigen (HLA) B27 heavy chain is known to bind to MHC Class I complexes containing the HLA-B27 heavy chain. This observation has been invoked previously in at least two different (but related) mol. explanations for the disease-association of the HLA-B27 allele. Here, we use a combination of fluorescence polarization, competitive inhibition and gel filtration chromatog. studies to show that a fluorescently-labeled peptide of the above sequence binds to two disease-associated subtypes of HLA-B27 (namely HLA-B*27:04 and HLA-B*27:05) but not to non-disease-associated subtypes (HLA-B*27:06 or HLA-B*27:09). This differential binding behavior is seen both in (a) peptide binding to complexes of heavy chain (HLA-B27) and light chain (β2 microglobulin), and in (b) peptide binding to β2 microglobulin-free heavy chains in the aggregated state. Such subtype-specific differences are not seen with two other control peptides known to bind to HLA-B27. Our results support the likelihood of differential peptide binding holding at least one of the keys to HLA-B27’s disease association In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mehdinia, Ali et al. published their research in Journal of the Iranian Chemical Society in 2017 | CAS: 38183-12-9

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 38183-12-9

Simultaneous screening of homotaurine and taurine in marine macro-algae using liquid chromatography-fluorescence detection was written by Mehdinia, Ali;Rostami, Simindokht;Dadkhah, Sahar;Fumani, Neda Sheijooni. And the article was included in Journal of the Iranian Chemical Society in 2017.Reference of 38183-12-9 This article mentions the following:

Simultaneous anal. of homotaurine and its homologous, taurine, is a highly challenging issue, especially in matrixes they exist simultaneously. A simple precolumn derivatization procedure combined with high-performance liquid chromatog.-fluorescence detection was developed for simultaneous determination of homotaurine and taurine in marine macro-algae. The analytes were derivated with o-phthalaldehyde at an ambient temperature and alk. medium. Calibration curves were linear in the ranges of 50-2500μg L-1 for homotaurine and 100-2500μg L-1 for taurine with the coefficients of determination higher than 0.998. Limits of detection of homotaurine and taurine were 15 and 30μg L-1, resp. Intraday (n = 6) and inter-day (n = 4) precisions of the method were satisfactory with relative standard deviations less than 6.0%. Good recoveries (>94%) were acquired by the method for extraction of homotaurine and taurine from algae matrixes. Liquid chromatog.-mass spectrometry was also used to confirm detection of the analytes in algae samples. The data suggest that the method was successfully applied to simultaneous determination of homotaurine and taurine in algae samples. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Marom, Ehud et al. published their patent in 2013 |CAS: 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Product Details of 60770-67-4

On February 21, 2013, Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai published a patent.Product Details of 60770-67-4 The title of the patent was Preparation of benzofurans and use thereof as synthetic intermediates. And the patent contained the following:

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Marom, Ehud et al. published their patent in 2011 |CAS: 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Related Products of 60770-67-4

On August 18, 2011, Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai published a patent.Related Products of 60770-67-4 The title of the patent was Process for preparation of Dronedarone and synthetic intermediates thereof. And the patent contained the following:

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, an intermediate in the preparation of Dronedarone. For example, a mixture of CuI, bis(methanesulfonyl)amine, N,N-dimethylglycine, K3PO4, 5-bromo-2-butylbenzofuran (preparation given), and DMF was refluxed for 24-48 h to afford N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide. The intermediate obtained above was reacted with 4-[3-(dibutylamino)propoxy]benzoyl chloride hydrochloride in the presence of aluminum chloride in dry dichloromethane at 5 – 10 °C overnight to afford N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzofuran-5-yl]-N-methylsulfonylmethanesulfonamide, which was treated with 5 M NaOH in THF at room temperature for 3 h to give Dronedarone as the final product. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Related Products of 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Related Products of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cai, Xiong et al. published their patent in 2008 |CAS: 60770-67-4

The Article related to imidazopyridine preparation hsp90 inhibitor cancer autoimmune neurodegenerative disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 60770-67-4

On September 25, 2008, Cai, Xiong; Qian, Changgeng; Zhai, Haixiao published a patent.Computed Properties of 60770-67-4 The title of the patent was Preparation of imidazo[4,5-c]pyridine derivatives as HSP90 inhibitors. And the patent contained the following:

Title compounds represented by the formula I [wherein U = N or CH; W = H, halo, amino, etc.; X = absent, O, S, etc.; Y = independently H, halo, NO2, CN or alkyl; Z = (alkylcarbonyl)amino or (di)alkylamino; Q = (un)substituted (hetero)aryl or (Hetero)cycloalkyl; V = H, (un)substituted aryl, alkenyl, etc.; and geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts, prodrugs and solvates thereof] were prepared as HSP90 inhibitors. For example, II was provided in a multi-step synthesis starting from N-(4-pentynyl)phthalimide. I were tested for inhibiting HSP90 chaperone activity in vitro assay and HSP90 competition binding (Fluorescence Polarization) assay. Thus, I and their pharmaceutical compositions are useful as HSP90 inhibitors for the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to imidazopyridine preparation hsp90 inhibitor cancer autoimmune neurodegenerative disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Qingcai et al. published their patent in 2019 |CAS: 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

On August 15, 2019, Chen, Qingcai; Zhao, Jun; Zhao, Xiaowei; Chen, Xiangfeng; Zong, Zaiwei; Lu, Hui published a patent.Application of 60770-67-4 The title of the patent was Nitrogen-containing heterocyclic compound, preparation method and application. And the patent contained the following:

The invention disclosed a kind of nitrogen-containing heterocyclic compound,its preparation method and application as potassium ion competitive acid retardant or gastric acid secretion inhibitor. The claimed compound is shown in structure I (ring A = saturated or unsaturated five member ring; X1,X2,X3 = C, N, O, S, etc.; a,b = bridge atom C or N; R1 = -SO2R4, -(CH2)nR4, or -CHR4R5; R4 = aryl, arylalkyl, arylalkenyl, benzocyclo, etc.; R5 = halo, nitro, cyano, etc.; n = 0, 1-6 integers; R2 = aryl, arylalkyl, heteroaryl, etc.; R3 = H, alkyl cycloalkyl). The claimed compound is prepared via multiple steps (example procedure given). The prepared compound has proton pump H+/K+-ATP enzyme inhibition effect, and is used for preventing and treating diseases related to inhibition of gastric acid secretion, such as peptic ulcer, zollinger-ellison syndrome, gastritis, erosive esophagitis, reflux esophagitis, symptomatic gastroesophageal reflux disease and the like. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Qingcai et al. published their patent in 2019 |CAS: 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

On August 13, 2019, Chen, Qingcai; Zhao, Jun; Zhao, Xiaowei; Chen, Xiangfeng; Zong, Zaiwei; Lu, Hui published a patent.Application of 60770-67-4 The title of the patent was Nitrogen-containing heterocyclic compound, preparation method and application. And the patent contained the following:

The invention disclosed a kind of nitrogen-containing heterocyclic compound,its preparation method and application as potassium ion competitive acid retardant or gastric acid secretion inhibitor. The claimed compound is shown in structure I (ring A = saturated or unsaturated five member ring; X1,X2,X3 = C, N, O, S, etc.; a,b = bridge atom C or N; R1 = -SO2R4, -(CH2)nR4, or -CHR4R5; R4 = aryl, arylalkyl, arylalkenyl, benzocyclo, etc.; R5 = halo, nitro, cyano, etc.; n = 0, 1-6 integers; R2 = aryl, arylalkyl, heteroaryl, etc.; R3 = H, alkyl cycloalkyl). The claimed compound is prepared via multiple steps (example procedure given). The prepared compound has proton pump H+/K+-ATP enzyme inhibition effect, and is used for preventing and treating diseases related to inhibition of gastric acid secretion, such as peptic ulcer, zollinger-ellison syndrome, gastritis, erosive esophagitis, reflux esophagitis, symptomatic gastroesophageal reflux disease and the like. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

El-Gezawy, Hani et al. published their research in Journal of Physical Chemistry B in 2005 |CAS: 53724-96-2

The Article related to photoactive yellow protein photochem photophys chromophore model bridged compound, General Biochemistry: Proteins and Their Constituents and other aspects.HPLC of Formula: 53724-96-2

On October 6, 2005, El-Gezawy, Hani; Rettig, Wolfgang; Danel, Andrzej; Jonusauskas, Gediminas published an article.HPLC of Formula: 53724-96-2 The title of the article was Probing the Photochemical Mechanism in Photoactive Yellow Protein. And the article contained the following:

Selectively bridged model compounds related to the chromophore in photoactive yellow protein have been synthesized where the single bond adjacent to the benzene ring (bond 1) and where both bond 1 and the adjacent double bond (bond 2) are bridged. They were compared to the nonbridged reference compound regarding their photophys. properties using steady-state and time-resolved fluorescence at various temperatures Quantum chem. calculations were addnl. performed and showed that several conformers are populated in the ground state. The neutral model compounds show that the nonradiative deactivation channel is linked to both single- and double-bond twisting. The relative importance of single-bond twisting is increased for the corresponding deprotonated hydroxy compounds with an enhanced donor character. The simultaneous photochem. activity of both single and double bonds explains the ease of photochem. isomerization in the confined environment of the natural PYP protein and also of the primary step in the vision process in rhodopsin. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).HPLC of Formula: 53724-96-2

The Article related to photoactive yellow protein photochem photophys chromophore model bridged compound, General Biochemistry: Proteins and Their Constituents and other aspects.HPLC of Formula: 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hong, Hui et al. published their patent in 2009 |CAS: 53724-96-2

The Article related to pyridine phenylpiperidinyloxy derivative preparation metabolic disorder, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 53724-96-2

On May 22, 2009, Hong, Hui; Xu, Xiang; Yu, Jiaxin; Singh, Rajinder; Darwish, Ihab S.; Thota, Sambaiah published a patent.Electric Literature of 53724-96-2 The title of the patent was Preparation of phenylpiperidinyloxypyridine derivatives for use as therapeutic agents in metabolic disorders. And the patent contained the following:

Title compounds I [B = substituted aryl or heteroaryl; E = CO, SO2, or bond; T = alkyl-OR10, alkyl-C(O)R10, alkyl-S(O)p, etc.; Y = (un)substituted amine; each R4 independently = halo, CN. NO2, alkyl, etc.; or two R4 on the same carbon optionally combine to form oxo; R10 = H, alkyl, haloalkyl, etc.; m = 0 to 4; n = 0 to 3; p = 0 to 2; provided that when B = Ph, then E is not CO], and their pharmaceutically acceptable salts, are prepared and disclosed as therapeutic agents in metabolic disorders. Thus, e.g., II was prepared by deprotection of tert-Bu 1-(pyridin-4-ylmethyl)piperidin-4-ylcarbamate followed by amidation with 6-chloropicolinic acid, and etherification with 1-(4-(trifluoromethyl)phenyl)piperidin-4-ol. Select I were evaluated for their ability to activate AMPK using enzyme-linked immunosorbent assays, e.g., II demonstrated an EC50 value of 0.1-0.5 μM. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2

The Article related to pyridine phenylpiperidinyloxy derivative preparation metabolic disorder, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reiser, Ulrich et al. published their patent in 2013 |CAS: 60770-67-4

The Article related to alkynylpyridine preparation smac mimetic antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 60770-67-4

On August 29, 2013, Reiser, Ulrich; Bader, Gerd; Spevak, Walter; Steffen, Andreas; Parkes, Alastair L. published a patent.Recommanded Product: 60770-67-4 The title of the patent was Preparation of 5-alkynylpyridines as SMAC mimetics. And the patent contained the following:

This invention relates to 5-alkynyl-pyridines I [R1 = H or alkyl; R2, R21 = H, (fluoro)alkyl; R3 = (un)substituted C6-10 aryl, 5-14 membered heteroaryl; R4 = H, (un)substituted C6-10 aryl, 5-14 membered heteroaryl, etc.; R5 = H, halo, alkyl, etc.; or R4 and R5 taken together form C6-10 aryl, 5-14 membered heteroaryl], to their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. Over two-hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from 5,6-dibromopyridin-2-amine and ethynyl-tri(propan-2-yl)silane, was described. Exemplified compounds I were tested in XIAP BIR3 and cIAP1 BIR3 binding assays (data given). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 60770-67-4

The Article related to alkynylpyridine preparation smac mimetic antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem