On August 18, 2011, Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai published a patent.Related Products of 60770-67-4 The title of the patent was Process for preparation of Dronedarone and synthetic intermediates thereof. And the patent contained the following:
The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, an intermediate in the preparation of Dronedarone. For example, a mixture of CuI, bis(methanesulfonyl)amine, N,N-dimethylglycine, K3PO4, 5-bromo-2-butylbenzofuran (preparation given), and DMF was refluxed for 24-48 h to afford N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide. The intermediate obtained above was reacted with 4-[3-(dibutylamino)propoxy]benzoyl chloride hydrochloride in the presence of aluminum chloride in dry dichloromethane at 5 – 10 °C overnight to afford N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzofuran-5-yl]-N-methylsulfonylmethanesulfonamide, which was treated with 5 M NaOH in THF at room temperature for 3 h to give Dronedarone as the final product. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Related Products of 60770-67-4
The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Related Products of 60770-67-4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem