Tag: 200-300

Protein Quantitation and Analysis of Purity was written by Campion, Eva M.;Loughran, Sinead T.;Walls, Dermot. And the article was included in Methods in Molecular Biology (New York, NY, United States) in 2017.Formula: C17H10O4 This article mentions the following:

The accurate quantitation of proteins and an anal. of their purity are essential in numerous areas of scientific research, and is a critical factor in many clin. applications. The large number and variety of techniques employed for this purpose is therefore not surprising. The selection of a suitable assay is dependent on such factors as the level of sensitivity required, the presence of interfering agents, and the composition of the protein itself. Here, protocols for the most commonly used protein determination methodologies are outlined, as well as for the more recently adapted technique of quant. immuno-Polymerase Chain Reaction. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A derivatisation agent selection guide was written by Tobiszewski, Marek;Namiesnik, Jacek;Pena-Pereira, Francisco. And the article was included in Green Chemistry in 2017.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

The study reported herein is aimed at the greenness assessment of 267 derivatization agents that are frequently applied in anal. chem. and related disciplines. Multicriteria decision anal. allowed obtaining three rankings of derivatization agents applied in liquid chromatog., gas chromatog. and chiral anal. The criteria of assessment included the safety information obtained from material safety data sheets and physicochem. and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatization agents, wherever the green chem. principle of avoiding derivatization cannot be fulfilled. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase was written by Ibrahim, Hany S.;Albakri, Mohamed E.;Mahmoud, Walaa R.;Allam, Heba Abdelrasheed;Reda, Ahmed M.;Abdel-Aziz, Hatem A.. And the article was included in Bioorganic Chemistry in 2019.Product Details of 38220-75-6 This article mentions the following:

Benzimidazole is an interesting scaffold constituting a main core in many anticancer agents against variable cell lines as Carbendazim (I) and Nocodazole (II). Accordingly, eighteen compounds of 2-((1H-benzoimidazol-2-yl)thio)-1-(aryl/heteroaryl)ethan-1-ones, in their sulfate salt and free forms, were designed and investigated as anticancer agents. In vitro preliminary screening of selected compounds by the National Cancer Institute (NCI) on a panel of 60 cell lines revealed renal cancer cell line (A498) as the most vulnerable cell line; accordingly, IC₅₀ values against A498 cell line were determined for compounds with the best results. The best inhibitory activity was for compound 4a with (IC₅₀ = 6.97 μM) compared to sunitinib as a reference drug (IC₅₀ = 6.99 μM). Compound 4a was further subjected to cell cycle anal. that indicated the decrease in cell population in the G2/M phase when compared to the untreated control cells. In addition, it showed significant increase in the late apoptosis in Annexin-V FTIC study compared to the control cells. An enzymic inhibitory study on compound 4a against c-Met and MAP kinases revealed its better activity against c-Met kinase with (IC₅₀ = 0.27 μM) compared to sunitinib (IC₅₀ = 0.18 μM). Mol. docking study was conducted to reveal the interactions of compound 4a in the active site of c-Met kinase. Computational ADME study was performed to insure that compound 4a has proper pharmacokinetic and drug-likeness properties. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescence detection and identification of eight sulphonamides using capillary electrophoresis on released excipients in lake water was written by Jamal, Shubi;Baderia, Vishal K.;Agrawal, Y. K.;Sanghi, S. K.. And the article was included in Arabian Journal of Chemistry in 2019.Formula: C17H10O4 This article mentions the following:

A simple and sensitive capillary electrophoresis method with fluorescence detection was developed for the determination of sulphanilamide, sulphamerazine, sulphacetamide and sulphanilic acid, sulphathiazole, Sulphisomidine, sulphadoxine and sulphadiazine in lake water. The sulfonamides were extracted from lake water, derivatized with fluorescamine and determination of sulfonamide was achieved using 20 mM borate buffer of pH 9.5 at an applied voltage of 25 kV. Detection was performed using UG-11 excitation filter of 405 nm and 495 nm emission filters. A fast, simple and sensitive method with limit of detection in the range 0.89-1.43 n mol L^-1 for all the four sulfonamides with good recoveries 80-110% is seen. Inter-day and intra-day validation of the separation method shows fairly good results. The detection and quantification limits for this newly developed method are too low to determine drug residues in lake water. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Convenient Synthesis of Some New 1,3,4-Thiadiazoles, Thiazoles, Pyrazolo[1,5-a]pyrimidines, Pyrazolo[5,1-c]triazine, and Thieno[3,2-d]pyrimidines Containing 5-Bromobenzofuran Moiety was written by Abdelhamid, Abdou O.;Fahmi, Abdelgawad A.;Baaiu, Basma S.. And the article was included in Journal of Heterocyclic Chemistry in 2016.SDS of cas: 38220-75-6 This article mentions the following:

A variety of heterocyclic compounds containing 5-bromobenzofuran moiety e.g., I were synthesized from 1-(5-bromobenzofuran-2-yl)ethanone. The structures of the newly synthesized compounds were elucidated by elemental anal., spectral data, chem. transformation, and alternative synthesis route whenever possible. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6SDS of cas: 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Prognostic significance of fluorescamine labeled serum albumin and globulin values in patients with diabetes mellitus results in end stage renal diseases was written by Jamal, Shubi;Agrawal, Y. K.. And the article was included in International Journal of Pharma and Bio Sciences in 2013.Recommanded Product: 38183-12-9 This article mentions the following:

Proteinurea is considered to be major prognostic factor in patients with certain chronic diseases, such as cancer and ESRD. High serum albumin, gamma globulin, beta-2 & alpha-1 microglobulin is common in patients with diabetes mellitus; nevertheless, the relationship between proteinuria and diabetes mellitus prognosis has not been verified. The mean arterial pressure was 30±9%. The mean serum albumin and globulin was 186.9±0.5mg/day. Patients with and without high urinary albumin levels were similar in age, because of diabetes mellitus. The survival rate of patients with proteinuria was 50.41% and 80.62% in those without proteinuria (P<0.001). The calibration curve for four specific proteins responsible for ESRD in diabetes was found linear in the range of 10^-9 to 10³nmolL^-1, correlation coefficient(r²) was found to be 0.9926. The LOD and LOQ were observed as 3.28nmolL^-1 to 23.80nmolL^-1. To elucidate the effect of labeled serum albumin and globulin level on prognosis of patients with diabetes mellitus results in ESRD. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The convenient use of fluorescamine for spectrofluorimetric quantitation of pramipexole in pure form and pharmaceutical formulation; application to content uniformity testing was written by Derayea, Sayed M.;Ahmed, Amal B.;Omar, Mahmoud A.;Abdelwahab, Nada S.;Abdelrahman, Maha M.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Synthetic Route of C17H10O4 This article mentions the following:

Pramipexole is a selective dopamine receptor agonist which is used in the treatment of Parkinson’s disease and restless legs syndrome. The present work illustrates the development and validation of a sensitive and selective spectrofluorometric method for quantitation of pramipexole (PMP) through its interaction with fluorescamine at pH 7.5 using aqueous borate buffer to produce a highly fluorescent product. The fluorescent intensity of the formed product was measured at 480 nm after excitation at 391 nm. Exptl. factors that could influence the formation, stability and the fluorescence intensity of the formed product were investigated and optimized. The linearity of the proposed method was achieved in the concentration range of 0.05-2.0μg/mL. The quantitation and detection limits were 47 and 15 ng/mL, resp. The proposed method has been validated in respect to guidelines of ICH and pharmaceutical tablets of PMP were successfully analyzed. Moreover, the method was applied for studying the content uniformity test according to the guidelines of USP. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Scope and Mechanism of the Redox-Active 1,2-Benzoquinone Enabled Ruthenium-Catalyzed Deaminative α-Alkylation of Ketones with Amines was written by Kirinde Arachchige, Pandula T.;Handunneththige, Suhashini;Talipov, Marat R.;Kalutharage, Nishantha;Yi, Chae S.. And the article was included in ACS Catalysis in 2021.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

The catalytic system formed in situ from the reaction of a cationic Ru-H complex with 3,4,5,6-tetrachloro-1,2-benzoquinone was found to mediate a regioselective deaminative coupling reaction of ketones with amines to form the α-alkylated ketone products. Both benzylic and aliphatic primary amines were found to be suitable substrates for the coupling reaction with ketones in forming the α-alkylated ketone products. The coupling reaction of PhCOCD₃ with 4-methoxybenzylamine showed an extensive H/D exchange on both α-CH₂ (41% D) and β-CH₂ (21%) positions on the alkylation product. The Hammett plot obtained from the reaction of acetophenone with para-substituted benzylamines p-X-C₆H₄CH₂NH₂ (X = OMe, Me, H, F, Cl, CF₃) showed a strong promotional effect by the amine substrates with electron-releasing groups (ρ = -0.49 ± 0.1). The most significant carbon isotope effect was observed on the α-carbon of the alkylation product (C_α = 1.020) from the coupling reaction of acetophenone with 4-methoxybenzylamine. The kinetics of the alkylation reaction from an isolated imine substrate led to the empirical rate law: rate = k[Ru][imine]. A catalytically active Ru-catecholate complex was synthesized from the reaction of the cationic Ru-H complex with 3,5-di-tert-butyl-1,2-benzoquinone and PCy₃. The DFT computational study was performed on the alkylation reaction, which revealed a stepwise mechanism of the [1,3]-carbon migration step via the formation of a Ru(IV)-alkyl species with a moderate energy of activation (ΔG^‡ = 32-42 kcal/mol). A plausible mechanism of the catalytic alkylation reaction via an intramol. [1,3]-alkyl migration of an Ru-enamine intermediate has been compiled on the basis of these exptl. and computational data. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Safety of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological activities of some new pyrimidines and isoxazoles bearing benzofuran moiety was written by Tirlapur, Vijay Kumar;Gandhi, Narasimha;Basawaraj, Raga;Rajendra Prasad, Y.. And the article was included in International Journal of ChemTech Research in 2010.COA of Formula: C10H7BrO2 This article mentions the following:

1-(5-Bromo-1-benzofuran-2-yl)-3-(substituted phenyl)-prop-2-en-1-one 2a-e were prepared by the reaction of 5-bromo-2-acetylbenzofuran 1 with different aromatic aldehydes in presence of alkali. Reaction of 2a-e with urea, thiourea and hydroxylamine hydrochloride to gave 4-(5-bromo-1-benzofuran-2-yl)-6-(substituted phenyl)-pyrimidine-2-ol 3a-e, 4-(5-bromo-1-benzofuran-2-yl)-6-(substituted phenyl)-pyrimidine-2-thiol 4a-e and 3-(5-bromo-1-benzofuran-2-yl)-5-(substituted phenyl)-4,5 dihydroisoxazole 5a-e resp. The characterization of all synthesized compounds was done by anal. and spectral studies. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6COA of Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microwave-promoted Heck and Suzuki coupling reactions of new 3-(5-bromobenzofuranyl)pyrazole in aqueous media was written by Dawood, Kamal M.;Darweesh, Ahmed F.;Shaaban, Mohamed R.;Farag, Ahmad M.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2018.Computed Properties of C10H7BrO2 This article mentions the following:

Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions of 3-(5-bromobenzofuran-2-yl)-1H-pyrazole with arylboronic acids and terminal olefins resp. were investigated using a benzothiazole-oxime palladium(II) complex, under both thermal and microwave-irradiation conditions in an open vessel using aqueous solvent. The benzothiazole-oxime-based Pd(II) complex was found to be an efficient and highly active pre-catalyst for the cross-coupling reactions, and for the preparation of new C-C cross-coupled compounds such as biaryls I [Ar = Ph, 4-MeC₆H₄, 3-thienyl, etc.] and alkenes II [R = CN, CO₂Et, CO₂Bu, Ph] of potential biol. interest which were difficult to obtain using other synthetic routes. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Computed Properties of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem