Tag: 200-300

Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides was written by Li, Ling;Wang, Chao-Yuan;Huang, Rongcai;Biscoe, Mark R.. And the article was included in Nature Chemistry in 2013.COA of Formula: C10H7BrO2 This article mentions the following:

Racemic and nonracemic secondary stannatranes I [R = EtCHMe, Me₂CH, 4-tetrahydropyranyl, (EtO₂CCH₂)CHMe, 3-octyl, PhCHMe, 1-methyl-4-piperidinyl, PhCH₂CH₂CHMe, (S)-PhCH₂CH₂CHMe, (S)-1-Boc-2-pyrrolidinyl] were prepared; I underwent regioselective Stille coupling reactions with aryl halides and triflates in the presence of bis(dibenzylideneacetone)palladium, the JackiePhos ligand II [R¹ = 3,5-(F₃C)₂C₆H₃], CuCl, and KF to yield secondary alkyl-substituted arenes such as Et 4-(2-butyl)benzoate in 26-94% yields (two of 23 reactions < 50% yield). Aryl halides and triflates with electron-donating and electron-withdrawing substituents were tolerated. Coupling of I [R = (S)-PhCH₂CH₂CHMe, 94% ee] with 2-bromopyridine or 2-bromo-6-methylquinoline yielded the coupling products with almost complete retention of stereochem. in 91-92% ee. The structure of a nonracemic (bromobenzoyl)pyrrolidinylbenzonitrile was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6COA of Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.COA of Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photoproduction Rates of One-Electron Reductants by Chromophoric Dissolved Organic Matter via Fluorescence Spectroscopy: Comparison with Superoxide and Hydrogen Peroxide Rates was written by Le Roux, Danielle M.;Powers, Leanne C.;Blough, Neil V.. And the article was included in Environmental Science & Technology in 2021.HPLC of Formula: 38183-12-9 This article mentions the following:

One-electron reductants (OER) photoproduced by chromophoric dissolved organic matter (CDOM) have been shown to be likely precursors for the formation of superoxide and subsequently hydrogen peroxide. An improved method that employs a nitroxide radical probe (3AP) has been developed and utilized to determine the photoproduction rates of OER from a diverse set of CDOM samples. 3AP reacts with OER to produce the hydroxylamine, which is then derivatized with fluorescamine and quantified spectrofluorometrically. Although less sensitive than traditional methods for measuring RO₂ , measuring RH provides a simpler and faster method of estimating RO₂ and is amenable to continuous measurement via flow injection anal. Production rates of OER (RH), superoxide (RO₂), and hydrogen peroxide (RH₂O₂) have a similar wavelength dependence, indicating a common origin. If all the OER react with mol. oxygen to produce superoxide, then the simplest mechanism predicts that RH/RH₂O₂ and RO₂/RH₂O₂ should be equal to 2. However, our measurements reveal RH/RH₂O₂ values as high as 16 (5.7-16), consistent with prior results, and RO₂/RH₂O₂ values as high as 8 (5.4-8.2). These results indicate that a substantial fraction of superoxide (65-88%) is not undergoing dismutation. A reasonable oxidative sink for superoxide is reaction with photoproduced phenoxy radicals within CDOM. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid analysis of sulfamethoxazole residue in milk based on fluorescence spectroscopy coupled with chemometrics was written by Zhang, Yan-ping;Feng, Shi-yun;Zhou, Peng;Liu, Xiao-ming. And the article was included in Shipin Gongye Keji in 2013.HPLC of Formula: 38183-12-9 This article mentions the following:

Antibiotic residues in animal tissues and products could bring risks to the health of consumers. The commonly employed methods for detecting antibiotic residues often involved time-consuming protocols, whereas the fluorescence method was characterized as rapid and sensitive. In this study, a method was developed for rapid screening of sulfamethoxazole residues in milk with fluorescence spectroscopy and the chemometrics tools. The established model was applied to 6 brands of com. milk including pasteurized and ultra heat-treated (UHT) milk (whole, skimmed, semi-skimmed, high calcium). The results showed a significant discrimination by partial least squares discriminant anal. (PLS-DA) between the neg. and pos. milk samples with a 3.12% of false neg. probability, which was below 5% required by the European Union. And quantification could be acquired by further anal. with partial least squares (PLS) with a recovery between 87.9%-131.6%. The correlation coefficient was 0.9992 in the linear range of 0-210 μg/kg, and the detection capability (CCβ) and detection limit (CCα) were 2.54 μg/L and 5.07 μg/L, resp. The average relative standard error of the prediction model was 3.24%. This method showed potential in rapid screening and anal. of sulfamethoxazole residues in milk. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, analgesic and anti-inflammatory activity of benzofuran pyrazole heterocycles was written by R, Kenchappa;Bodke, Yadav D.. And the article was included in Chemical Data Collections in 2020.Application of 38220-75-6 This article mentions the following:

The present work describes the synthesis of series of 3-(5-substituted-1-benzofuran-2-yl)-1-(4-substituted phenyl)-1H-pyrazole-4-carbaldehyde derivatives I (R = H, Br; R¹ = H, 4-CH₃, 4-F, 4-Cl, 4-NO₂) and (Z)-2-((3-(5-Substituted benzofuran-2-yl)-1-p-substituted-1H-pyrazol-4-yl)methylene)-2,3-dihydro-5,6-dimethoxyinden-1-one derivatives II. Among the synthesized compounds, I (R = H; R¹ = H), I (R = Br; R¹ = 4-Cl) and I (R = Br; R¹ = 4-NO₂) and II were performed for preliminary screening of their analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by acetic acid induced writhing test and carrageenan-induced rat paw edema model resp. Among the tested compounds, II (R = Br; R¹ = 4-Cl), II (R = H; R¹ = 4-NO₂) and II (R = Br; R¹ = 4-NO₂) were found to have higher analgesic activity with% of protection ranging from 50.49-60.53 and the compounds I (R = Br; R¹ = 4-Cl), I (R = Br; R¹ = 4-NO₂) and II (R = Br; R¹ = 4-Cl) exhibited promising anti-inflammatory activity with% of protection 66.62-72.23. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Assaying Collagenase Activity by Specific Labeling of Freshly Generated N-Termini with Fluorescamine at Mildly Acidic pH was written by Santra, Mithun;Luthra-Guptasarma, Manni. And the article was included in International Journal of Peptide Research and Therapeutics in 2020.SDS of cas: 38183-12-9 This article mentions the following:

Collagenases are important enzymes frequently used for isolation of cells. Accurate estimation of collagenase activity is an important requirement. Available techniques for assaying collagenase activity are (i) ninhydrin-based assays, in which ninhydrin reacts with freshly generated N-termini resulting from collagenase action upon collagen, with a colorimetric read-out, (ii) synthetic substrate-based assays, in which collagenase action releases either a radioactive group or a fluorescent moiety. These methods are associated with some drawbacks. Here, we have standardized a simple, cost-effective method for assaying collagenase activity, using fluorescence readouts of N-terminal-specific fluorescamine adduction with peptides and proteins at pH 6.0. Collagenase-mediated degradation of gelatin and collagen was performed at pH 7.0. Following incubation, fluorescamine was added at pH 6.0. A standard plot based on the use of BSA (bovine serum albumin) was used for determination of the moles of freshly-generated N-termini detected, based on fluorescence owing to fluorescamine adduction to N-termini. The method was also tested with two other proteases (trypsin and cathepsin-K). Specific reaction of fluorescamine with α amino groups at pH 6.0 can be used for labeling of freshly generated N-termini in collagen subjected to degradation by a collagenase. The kinetic parameters determined by the fluorescamine assay are comparable to those determined previously. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9SDS of cas: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.SDS of cas: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of Angiotensin-(1-7) with HPLC/Fluorescence-Detection was written by Russ, Miriam;Hauser, Susanne;Wintersteiger, Reinhold;Greilberger, Joachim;Andrae, Michaela;Ortner, Astrid. And the article was included in Journal of Fluorescence in 2016.Application of 38183-12-9 This article mentions the following:

Angiotensin-(1-7) is an important active component in the renin-angiotensin-system. Due to its cardio protective effects it is now under investigation in combination with antioxidants as a reperfusion solution The combination showed impressive effects on isolated hearts of male Wistar rats after induced ischemia. In this work a high performance liquid chromatog. method with fluorescence detection was developed for the first time for in-process measurements as well as for stability tests of the peptide in the novel antioxidant-containing Karal solution For fluorescence detection of angiotensin-(1-7) fluorescamine as derivatization dye was applied. Under optimized conditions the method showed linearity over the range of 50 to 5000 ng/mL with R² of 0.9988 and an overall precision better than 5.0%. LOD and LOQ were determined to be in the femtomol range on column. It was found that stability of angiotensin-(1-7) could be significantly improved in the antioxidant containing preparation compared to aqueous solutions In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trypanocidal diamidines with three rings in two isolated ring systems was written by Dann, Otto;Fernbach, Rainer;Pfeifer, Wolfgang;Demant, Ekke;Bergen, Gerhard;Lang, Siegfried;Luerding, Gerd. And the article was included in Justus Liebigs Annalen der Chemie in 1972.Category: benzofurans This article mentions the following:

According to known methods, diamidines were prepared, which are derived from 5- or 6-amidino-2-(p-amidinophenyl)thionaphthene or -benzofuran type by further variation of the condensed 5-membered ring, by insertion of a 1- o 2-at. bridge between the 2 ring systems, and by variation of the amidino group. Prepared were the benzimidazole I [A = C(NH2):-N+H2 Cl-], the indazoles II (A in 5 or 6 position), the indolizines III, the pyrimidazoles IV, the benzotriazole V, the thionaphthenes VI and VII (X = p-AC6H4 or A), the thio ethers VIII, the naphthalene IX, the thinaphthenes X (Z = CO, CH2, or CONH), and the benzofurans XI (Z = CO, CH2, CH:CR1, CH2CHR1, CH2O, CH2S, or CH2SO2; R,R1 = H or Me). One or both amidino group(s) of the parent thionaphthene or benzofuran (X and XI, Z = bond) were addnl. converted e.g. into the 2-amino-6-methyl-4-pyrimidinylamino, N:NNHC6H4A-p, NHC-(:NH)NH2, or CH:NN:C(NH2)2 group. Only II (A in 5 position) and V retained the trypanocidal properties. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Category: benzofurans).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

New insights in the chemical functionalization of graphene oxide by thiol-ene Michael addition reaction was written by Pineiro-Garcia, Alexis;Vega-Diaz, Sofia M.;Tristan, Ferdinando;Meneses-Rodriguez, David;Labrada-Delgado, Gladis Judith;Semetey, Vincent. And the article was included in FlatChem in 2021.Computed Properties of C17H10O4 This article mentions the following:

Graphene oxide (GO) is a carbon material with wide chem., and its functionalization represents the main challenge to develop multi-functional materials for different applications. Besides to epoxide and carboxyl groups, the alkenes that arise during the graphite oxidation seem to provide an excellent approach for developing selective reactions. In specific, α,β-unsaturated acids can be functionalized by thiol-ene Michael addition (TEMA) using base catalysts. However, when base catalysts are used, the thiol-epoxide ring opening reaction (TEROR) has been considered as the predominant and unique reaction. Therefore, there is a need to understand the reactivity of the GO when TEMA and TEROR take place from a qual. and quant. point of view. Herein, we studied the functionalization of GO and reduced graphene oxide (RGO) with cysteamine (CA) using different base catalysts. XPS results revealed that despite the thermal reduction of GO, the functionalization was possible confirming the coupling reaction between the CA and α,β-unsaturated acids of RGO by TEMA. In addition, a quant. anal. was conducted via fluorescent labeling corroborating that TEMA produced more CA mols. bonded to GO than TEROR. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Condensation-cyclodehydration of 2,4-dioxobutanoates: synthesis of new esters of pyrazoles and isoxazoles and their antimicrobial screening was written by Siddiqui, Naqui Jahan;Idrees, Mohammad. And the article was included in Pharma Chemica in 2014.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Series of pyrazole-3-carboxylates I (X = NH, H₂NCON; R¹ = R³ = H, R² = Br; R¹ = Me, R² = Cl, R³ = H, Cl; R⁴ = Me) and isoxazole-3-carboxylates I (X = O; R¹ – R³ as above; R⁴ = Et) were synthesized by the reaction of 4-(benzofuran-2-yl)-2,4-dioxobutanoates II with active nitrogen nucleophiles (hydrazine hydrate, hydroxylamine hydrochloride or semicarbazide hydrochloride) via condensation-cyclodehydration sequence. The synthesized compounds I were evaluated for their antimicrobial activity against Gram pos. and Gram neg. bacteria and fungi. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization, antimicrobial and in-silico studies of (1,1-dibenzofuran-2-yl) ethyl terephthalamide derivatives was written by Gurunathan, Krishnaswamy;R., Desai Nivedita;Hanuma, Naika Raja Naika;B., Aruna Kumar Doyijode;S., Sreenivasa. And the article was included in Research Journal of Chemistry and Environment in 2021.HPLC of Formula: 38220-75-6 This article mentions the following:

In search of new benzofuran derivatives of biol. importance, sym. terephthalamide derivatives I [R = H, Cl, Br; R¹ = H, Cl, Br] of benzofuran were synthesized from 2- acetylbenzofuran. The synthesis of title compounds followed a sequence of condensation, reduction and coupling reactions. The structures of all the newly synthesized compounds were established by FT-IR, ¹H and ¹³C NMR and MS spectral methods. The formation of amine follows novel reduction method under microwave irradiation All the synthesized compounds I, II and III were subjected to invitro antimicrobial studies and found to be moderate antibacterial agent and poor antifungal agents. In correlation, the mode of action of these compounds I, II and III as antimicrobial agents was determined by the in-silico studies. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6HPLC of Formula: 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem