Tag: 200-300

A fluorometric assay to determine average modification rate of three kinds of PEG-rhGHs was written by Li, Jing;He, Hui;Cheng, Su-yuan;Liang, Cheng-gang. And the article was included in Yaowu Fenxi Zazhi in 2014.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

The average rate of 3 different PEG modifications of rhGH by deriving free amines with fluorescamine was determined MALDI-TOF mass spectrometry was used to detect relative mol. mass of PEG, rhGH and the conjugations to calculate the theor. rate of PEG modification. A fluorometric method was established by optimization and validation through selection of the excitation and emission wavelength, an orthogonal experiment, an interference test of free PEG and the stability study of the reaction. The theor. value of modification rate was 10%, which was validated by MALDI-TOF mass. Validation results were as below: The excitation and emission wavelengths were 390 nm and 480 nm, resp. The pH value of solution had the greatest effect on the result. PEG with low content had no effect on the result. The relative fluorescence unit was stable within the first 8 min. The actual modification rates of three different PEG-rhGHs were 8.8%, 9.8% and 9.5%, resp., which were close to the theor. value. The fluorometric derivatization method is suitable for determination of the average rate of modification for PEG-rhGH. The average modification rate of 3 kinds of PEG-rhGHs is 10%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

One- and Two-dimensional High-performance Thin-layer Chromatography as an Alternative Analytical Tool for Investigating Polyphenol-Protein Interactions was written by Tscherch, Kathrin;Biller, Julia;Lehmann, Mareen;Trusch, Maria;Rohn, Sascha. And the article was included in Phytochemical Analysis in 2013.COA of Formula: C17H10O4 This article mentions the following:

IntroductionPolyphenols and simple phenolic compounds are able to react with other food constituents during processing and storage. In the past, it has been shown that their reaction with proteins can lead to changes of the technofunctional or even physiol. properties of both compound classes. However, identification of specific binding sites of small mols. within a protein sequence and the corresponding conformational position is still challenging. ObjectiveInvestigating the reaction between different food proteins and phenolic compounds in alk. medium with one- and two-dimensional high-performance thin-layer chromatog. HPTLC coupled to matrix-assisted laser desorption/ionisation MALDI with time-of-flight TOF MS for analyzing the peptide profiles after tryptic digestion. Methods: After modification with phenolic compounds, protein derivatives were digested and peptides were separated with one- and two-dimensional HPTLC. Peptide profiles were detected with visible and UV wavelengths as well as with fluorescamine, ninhydrin and 2,2′-azino-bis3-ethylbenzothiazoline-6-sulfonic acid staining. In order to perform mass spectrometric measurements, peptides separated in the first dimension were analyzed by MALDI/TOF/MS. Results: Results show that the phenolic acids applied in this study show different specificity and susceptibility when modifying proteins resulting in changes of the peptide profiles, peptide quantity, polarity, UV-activity, radical-scavenging activity and mol. mass. ConclusionOne- and two-dimensional HPTLC supported by mass spectrometric detection represents an innovative, alternative tool for investigating and understanding polyphenol-protein interactions. This approach enables the identification of binding sites inside the protein chain and contributes to understanding the mechanism of polyphenol-protein interactions in vitro and in vivo. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides was written by Lu, Changhui;Gu, Yang;Wu, Jiang;Gu, Yucheng;Shen, Qilong. And the article was included in Chemical Science in 2017.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of halo-substituted heteroarenes, such as pyridines, pyrimidines, quinolines, thiophenes, benzofurans, etc., were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. The reactions were conducted under mild conditions, and several common functional groups were tolerated. The current method represented the first general method for the site-specific incorporation of difluoromethyl moiety into heteroarenes. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of 3-heteroaryloxindoles through t-BuOCl-mediated oxidation of 3-heteroarylindoles was written by Baroni, Marco;Lesma, Giordano;Puleio, Letizia;Sacchetti, Alessandro;Silvani, Alessandra;Zanchet, Marco. And the article was included in Synthesis in 2010.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

The oxidation of 3-heteroarylindoles, e.g., I (R = H, Cl) to the corresponding oxindoles, e.g., II (R = H, Cl; X = H, Cl), with t-Bu hypochlorite has been investigated. Under carefully adjusted conditions, desired products can be obtained on preparative scale. Two competing pathways seem to contribute to the reaction mechanism, affording 3-heteroaryloxindoles bearing hydrogen or chlorine at C3, depending on stereoelectronic factors. The present methodol. appears also generally applicable for the preparation of simple 3-aryloxindoles. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Experimental and Computational Prediction of Glass Transition Temperature of Drugs was written by Alzghoul, Ahmad;Alhalaweh, Amjad;Mahlin, Denny;Bergstroem, Christel A. S.. And the article was included in Journal of Chemical Information and Modeling in 2014.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Glass transition temperature (T_g) is an important inherent property of an amorphous solid material which is usually determined exptl. In this study, the relation between T_g and melting temperature (T_m) was evaluated using a data set of 71 structurally diverse druglike compounds Further, in silico models for prediction of T_g were developed based on calculated mol. descriptors and linear (multilinear regression, partial least-squares, principal component regression) and nonlinear (neural network, support vector regression) modeling techniques. The models based on T_m predicted T_g with an RMSE of 19.5 K for the test set. Among the five computational models developed herein the support vector regression gave the best result with RMSE of 18.7 K for the test set using only four chem. descriptors. Hence, two different models that predict T_g of drug-like mols. with high accuracy were developed. If T_m is available, a simple linear regression can be used to predict T_g. However, the results also suggest that support vector regression and calculated mol. descriptors can predict T_g with equal accuracy, already before compound synthesis. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Three-dimensional direct visualization of silica dispersion in polymer-based composites was written by Feng, Zemin;Zhong, Jinpan;Guan, Weijiang;Tian, Rui;Lu, Chao;Ding, Caifeng. And the article was included in Analyst (Cambridge, United Kingdom) in 2018.Related Products of 38183-12-9 This article mentions the following:

The uniform dispersion of silica fillers or other neutral fillers in the polymer matrix is significant for fabricating high-performance polymer-based composites. However, there is a long-standing challenge to provide a comprehensive, wide-area and real 3D distribution map to achieve direct visualization for the dispersion state of neutral silica. Herein, we propose a novel strategy for modifying silica fillers with com. fluorophores to form fluorescent fillers in a standard manner. Through fluorescence imaging technol., we successfully observed the 2D-planar and 3D-spatial dispersion states of silica fillers in the polymer matrix. This success not only provides a visualized evaluation method for the spatial dispersion of an oxide filler, but also offers great potential in the further establishment of industrialized standards for the polymer-based composite industry. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, reactions and biological evaluation of some novel 5-bromobenzofuran-based heterocycles was written by Halawa, Ahmed Hamdy. And the article was included in World Journal of Organic Chemistry in 2014.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Condensation of 2-acetyl-5-bromobenzofuran with Me hydrazinecarbodithioate or thiosemicarbazide afforded the corresponding hydrazone derivatives I (R = 5-bromo-2-benzofuryl; R¹ = MeS, NH₂); the product I (R¹ = MeS) was further S-alkylated with alkyl halides. Condensation of dithioester I (R¹ = MeS) with hydrazonyl halides R²C(O)C(X):NNHPh (R² = Me, X = Cl; R² = Ph, X = Br) gave 1,3,4-thiadiazoles II. Thiosemicarbazone I (R¹ = NH₂) reacted with acetic anhydride and various halogenated compounds to afford a variety of ethylidenehydrazono-substituted thiazoles and thiadiazoles, e.g. III from Et bromoacetate. The compound III underwent further condensation reactions with aromatic aldehydes, Ph isothiocyanate/chloroacetonitrile or tetracyanoethylene to give the corresponding methylidene-substituted and benzopyran-fused thiazoles. The coupling of III with DMF-DMA afforded enaminone, which on treatment with heterocyclic amines yielded the corresponding heterocycle-fused thiazoles. Some of the newly synthesized compounds showed promising antimicrobial activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Safety of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Highly sensitive spectrofluorimetric method for determination of doxazosin through derivatization with fluorescamine; Application to content uniformity testing was written by Omar, Mahmoud A.;Hammad, Mohamed A.;Salman, Baher I.;Derayea, Sayed M.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2016.Recommanded Product: 38183-12-9 This article mentions the following:

A highly sensitive, simple and selective spectrofluorimetric method has been developed and validated for determination of doxazosin mesylate in pure form, pharmaceutical formulations and human plasma. The method is based on the reaction between doxazosin mesylate and fluorescamine in Teorell buffer solution (pH 3) to give highly fluorescent derivative that can be measured at 489 nm using excitation wavelength of 385 nm. Different exptl. parameters affecting the reaction were carefully studied and optimized. The calibration plot was constructed over the concentration range of 16-400 ng mL^– 1 with quantitation limit of 14.3 ng mL^– 1. The developed procedure was validated according to ICH guidelines and the results were satisfactory. The proposed method has been successfully applied to the anal. of the cited drug in its pharmaceutical preparations as well as for content uniformity testing. The results showed excellent agreement with the reported method with respect to precision and accuracy. In addition, the drug concentration was determined in the spiked human plasma by the suggested method with % recovery in the range of 96.2-98.3% (SD; 0.76-0.93, n = 5). In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Novel Quantitative Spectrophotometric Method for the Analysis of Vigabatrin in Pure Form and in Pharmaceutical Formulation was written by Bkhaitan, Majdi Mohammad;Mirza, Agha Zeeshan. And the article was included in Current Pharmaceutical Analysis in 2016.Related Products of 38183-12-9 This article mentions the following:

Background: Vigabatrin is a variant of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It reduces seizure activities by inhibiting irreversibly GABA transaminase and increasing GABA concentrations Objective: This study presents simple, sensitive, extraction-free, and cost-efficient estimation of vigabatrin using a spectrophotometric method in pharmaceutical formulation. Method: The method relies on the development of water-soluble, blue-violet colored complexes of vigabatrin and ninhydrin in a phosphate buffer of pH 7.4 with λmax at 565 nm. Linearity, accuracy, precision, and specificity were performed as validation parameters for this method. Results: Assessment of different anal. factors was carried out, and statistical anal. was performed to validate the results. The findings showed a linear progression in absorbance when the concentration of vigabatrin was increased. The correlation coefficient value (r2) of 0.9981 was observed The operations followed the Beer’s law in the span of 40-200 μgmL-1 with a molar absorptivity of 5.16×103 Lmol-1cm-1. Recovery values in the marketed formulation of the assay method indicated no interference from the common additives and excipients. The limits of detection and quantification were found to be 6.0 and 40 μgmL-1, resp. Conclusion: The presented method has demonstrated to be delicate, reliable, explicit, and intuitive that can prove beneficial for regular laboratory examination of vigabatrin in pharmaceutical dosage forms. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of 14 sulfonamide residues in shrimps by high performance liquid chromatography coupled with post-column derivatization was written by Huang, Dongmei;Huang, Xuanyun;Gu, Runrun;Hui, Yunhua;Tian, Liangliang;Feng, Bing;Zhang, Xuan;Yu, Huijuan. And the article was included in Sepu in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

A method for the determination of 14 sulfonamide residues in shrimps by high performance liquid chromatog. coupled with post-column derivatization was established. The sulfonamide residues were extracted with Et acetate after adding sulfapyridine as internal standard The extracts were vacuum-concentrated and reverse-extracted by 2 mol/L hydrochloric acid solution for clean-up, and then the hydrochloric acid solution was defatted with n-hexane. The solution after filtration was blended with a mixed solution of methanol, acetonitrile and 3.5 mol/L sodium acetate solution (5:5:20, volume/volume/v). The sulfonamides were separated on a C₁₈ column by RP-HPLC and online derivatized with a fluorescamine and detected with a fluorescence detector. The standard addition method was used for quant. anal. The parameters of post-column derivatization system, such as concentration of fluorescamine solution, velocity of reagent solution and reaction temperature, were optimized. The calibration curves of the method showed good linearity in the range of 5-200 μg/L. The limits of quantification (LOQ, S/N = 10) were 1.0-5.0 μg/kg for the 14 sulfonamides. The recoveries were 77.8%-103.6% in the spiked range of 1.0-100.0 μg/kg in shrimps with the relative standard deviations of 2.9%-9.1% (n = 6). The results indicated that the method is sensitive, efficient and more accurate. It is suitable for the simultaneous determination of the 14 sulfonamide residues in shrimps. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem