Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides was written by Lu, Changhui;Gu, Yang;Wu, Jiang;Gu, Yucheng;Shen, Qilong. And the article was included in Chemical Science in 2017.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:
A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of halo-substituted heteroarenes, such as pyridines, pyrimidines, quinolines, thiophenes, benzofurans, etc., were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. The reactions were conducted under mild conditions, and several common functional groups were tolerated. The current method represented the first general method for the site-specific incorporation of difluoromethyl moiety into heteroarenes. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem