Synthesis of 3-heteroaryloxindoles through t-BuOCl-mediated oxidation of 3-heteroarylindoles was written by Baroni, Marco;Lesma, Giordano;Puleio, Letizia;Sacchetti, Alessandro;Silvani, Alessandra;Zanchet, Marco. And the article was included in Synthesis in 2010.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:
The oxidation of 3-heteroarylindoles, e.g., I (R = H, Cl) to the corresponding oxindoles, e.g., II (R = H, Cl; X = H, Cl), with t-Bu hypochlorite has been investigated. Under carefully adjusted conditions, desired products can be obtained on preparative scale. Two competing pathways seem to contribute to the reaction mechanism, affording 3-heteroaryloxindoles bearing hydrogen or chlorine at C3, depending on stereoelectronic factors. The present methodol. appears also generally applicable for the preparation of simple 3-aryloxindoles. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem