A Novel Quantitative Spectrophotometric Method for the Analysis of Vigabatrin in Pure Form and in Pharmaceutical Formulation was written by Bkhaitan, Majdi Mohammad;Mirza, Agha Zeeshan. And the article was included in Current Pharmaceutical Analysis in 2016.Related Products of 38183-12-9 This article mentions the following:
Background: Vigabatrin is a variant of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). It reduces seizure activities by inhibiting irreversibly GABA transaminase and increasing GABA concentrations Objective: This study presents simple, sensitive, extraction-free, and cost-efficient estimation of vigabatrin using a spectrophotometric method in pharmaceutical formulation. Method: The method relies on the development of water-soluble, blue-violet colored complexes of vigabatrin and ninhydrin in a phosphate buffer of pH 7.4 with λmax at 565 nm. Linearity, accuracy, precision, and specificity were performed as validation parameters for this method. Results: Assessment of different anal. factors was carried out, and statistical anal. was performed to validate the results. The findings showed a linear progression in absorbance when the concentration of vigabatrin was increased. The correlation coefficient value (r2) of 0.9981 was observed The operations followed the Beer’s law in the span of 40-200 μgmL-1 with a molar absorptivity of 5.16×103 Lmol-1cm-1. Recovery values in the marketed formulation of the assay method indicated no interference from the common additives and excipients. The limits of detection and quantification were found to be 6.0 and 40 μgmL-1, resp. Conclusion: The presented method has demonstrated to be delicate, reliable, explicit, and intuitive that can prove beneficial for regular laboratory examination of vigabatrin in pharmaceutical dosage forms. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).
4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 38183-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem