Synthesis, analgesic and anti-inflammatory activity of benzofuran pyrazole heterocycles was written by R, Kenchappa;Bodke, Yadav D.. And the article was included in Chemical Data Collections in 2020.Application of 38220-75-6 This article mentions the following:
The present work describes the synthesis of series of 3-(5-substituted-1-benzofuran-2-yl)-1-(4-substituted phenyl)-1H-pyrazole-4-carbaldehyde derivatives I (R = H, Br; R1 = H, 4-CH3, 4-F, 4-Cl, 4-NO2) and (Z)-2-((3-(5-Substituted benzofuran-2-yl)-1-p-substituted-1H-pyrazol-4-yl)methylene)-2,3-dihydro-5,6-dimethoxyinden-1-one derivatives II. Among the synthesized compounds, I (R = H; R1 = H), I (R = Br; R1 = 4-Cl) and I (R = Br; R1 = 4-NO2) and II were performed for preliminary screening of their analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by acetic acid induced writhing test and carrageenan-induced rat paw edema model resp. Among the tested compounds, II (R = Br; R1 = 4-Cl), II (R = H; R1 = 4-NO2) and II (R = Br; R1 = 4-NO2) were found to have higher analgesic activity with% of protection ranging from 50.49-60.53 and the compounds I (R = Br; R1 = 4-Cl), I (R = Br; R1 = 4-NO2) and II (R = Br; R1 = 4-Cl) exhibited promising anti-inflammatory activity with% of protection 66.62-72.23. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application of 38220-75-6).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 38220-75-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem