Category: benzofurans. Recently I am researching about ISCHEMIA/REPERFUSION INJURY; INFLAMMASOME ACTIVATION; LIGUSTILIDE; STROKE; NEUROTOXICITY; PATHWAY; RATS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072636, 81473219]; Sichuan Science and Technology Programs [2014JY0151, 2018SZ0015]; Fundamental Research Funds for the Central Universities, Science Foundation for Excellent Youth Scholars in Sichuan Province [2017JQ0014]; 111 Project of the National Ministry of Education [B18035]. Published in ELSEVIER in AMSTERDAM ,Authors: Li, X; Shi, MQ; Chen, C; Du, JR. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one
The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous studies showed that ligustilide (LIG) had a dose-dependent neuroprotective effect on various models of cerebral ischemia and dementia in vivo and in vitro. CD21, a kind of phthalide derivative, was modified from LIG. In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-alpha and IL-1 beta. Moreover, CD21 significantly inhibited the activation of TLR4/NF-kappa B signaling pathway mediated by HMGB1 and NLRP3/ASC/Caspase-1 signaling pathway mediated by Cathepsin B, thus inhibiting the activation of NLRP3 inflammasome. Our results demonstrated that CD21 may exert a neuroprotection by inhibiting NLRP3 inflammasome activation after cerebral ischemia. These findings provide a new strategy for the treatment of ischemic stroke.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem