Trypanocidal diamidines with three rings in two isolated ring systems was written by Dann, Otto;Fernbach, Rainer;Pfeifer, Wolfgang;Demant, Ekke;Bergen, Gerhard;Lang, Siegfried;Luerding, Gerd. And the article was included in Justus Liebigs Annalen der Chemie in 1972.Category: benzofurans This article mentions the following:
According to known methods, diamidines were prepared, which are derived from 5- or 6-amidino-2-(p-amidinophenyl)thionaphthene or -benzofuran type by further variation of the condensed 5-membered ring, by insertion of a 1- o 2-at. bridge between the 2 ring systems, and by variation of the amidino group. Prepared were the benzimidazole I [A = C(NH2):-N+H2 Cl-], the indazoles II (A in 5 or 6 position), the indolizines III, the pyrimidazoles IV, the benzotriazole V, the thionaphthenes VI and VII (X = p-AC6H4 or A), the thio ethers VIII, the naphthalene IX, the thinaphthenes X (Z = CO, CH2, or CONH), and the benzofurans XI (Z = CO, CH2, CH:CR1, CH2CHR1, CH2O, CH2S, or CH2SO2; R,R1 = H or Me). One or both amidino group(s) of the parent thionaphthene or benzofuran (X and XI, Z = bond) were addnl. converted e.g. into the 2-amino-6-methyl-4-pyrimidinylamino, N:NNHC6H4A-p, NHC-(:NH)NH2, or CH:NN:C(NH2)2 group. Only II (A in 5 position) and V retained the trypanocidal properties. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Category: benzofurans).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem