Fluorescence detection and identification of eight sulphonamides using capillary electrophoresis on released excipients in lake water was written by Jamal, Shubi;Baderia, Vishal K.;Agrawal, Y. K.;Sanghi, S. K.. And the article was included in Arabian Journal of Chemistry in 2019.Formula: C17H10O4 This article mentions the following:
A simple and sensitive capillary electrophoresis method with fluorescence detection was developed for the determination of sulphanilamide, sulphamerazine, sulphacetamide and sulphanilic acid, sulphathiazole, Sulphisomidine, sulphadoxine and sulphadiazine in lake water. The sulfonamides were extracted from lake water, derivatized with fluorescamine and determination of sulfonamide was achieved using 20 mM borate buffer of pH 9.5 at an applied voltage of 25 kV. Detection was performed using UG-11 excitation filter of 405 nm and 495 nm emission filters. A fast, simple and sensitive method with limit of detection in the range 0.89-1.43 n mol L-1 for all the four sulfonamides with good recoveries 80-110% is seen. Inter-day and intra-day validation of the separation method shows fairly good results. The detection and quantification limits for this newly developed method are too low to determine drug residues in lake water. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).
4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem