Category: 129-18-0

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Histamine release inhibition in antiinflammatory mechanism.Safety of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Sinomenine (50 mg/kg, i.p., twice daily, increasing daily dose by 100 mg/kg for 6 days) depleted skin histamine by >80%, inhibited induced egg-white edema by 68%, and decreased the wall weight of croton oil-induced granuloma pouches in rats. Antiinflammatory drugs, sodium salicylate, aminopyrine, sodium butazolidine, cortisone, and guaiazulene, inhibited both degranulation and histamine release induced by compound 48/80 of mast cells isolated from rat peritoneal fluid, and this inhibitory action was decreased in the presence of glucose, dinitrophenol, dicumarol, and warfarin. Prevention of edema provoked by anti-rat serum was roughly correlated to the potency of degranulation-inhibiting effect of the antiinflammatory agents. Antiinflammatory agents may prevent histamine release from the tissue, mainly by inhibiting mast cell degranulation, and prevent the contraction of endothelial cells by their uncoupling activities.

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Reid, M. E.; Bieri, J. G.; Plack, P. A.; Andrews, E. L. published the article 《Nutritional studies with the guinea pig. X. Determination of the linoleic acid requirement》. Keywords: CHROMATOGRAPHY; CITRATES; DERMATITIS; DIETARY FATS; ERYTHROCYTES; EXPERIMENTAL LAB STUDY; FATTY ACIDS, ESSENTIAL; GROWTH; GUINEA PIGS; KETOGLUTARIC ACID; LINOLEIC ACID; LIPID METABOLISM.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

cf. CA 59, 9144d. Young male guinea pigs were reared for 6-14 weeks with purified diets containing varying levels of linoleic acid as corn oil, safflower oil, or methyl linoleate. A dietary level of about 1% of calories as linoleic acid was necessary for normal growth and skin condition. The fatty acid composition of erythrocytes from animals fed safflower oil was determined and the ratios of 5,8,11-eicosatrienoic-to-arachidonic (20:3/20:4) or oleic-to-linoleic ( 18:1/18:2) acids compared with the performance of the animals with respect to growth and dermal symptoms. One per cent of calories as linoleic acid gave a 20:3/20:4 ratio of 0.13 to 0.17, and a 18:1/18:2 ratio of 1.41 to 1.14. Homogenates of liver from linoleic acid-deficient guinea pigs had an elevated rate of oxidation of citrate and α-ketoglutarate.

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HPLC of Formula: 129-18-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Effect of some antipyretic drugs on Herpes simplex virus infection in tissue culture. Author is Olkowska, Danuta; Wroblewska-Mularczykowa, Zofia.

Among 8 analgesic, antipyretic drugs tested for activity against herpesvirus in epithelial monkey kidney cell cultures, acetylsalicylic acid (I) [50-78-2], sodium salicylate [54-21-7], phenylbutazone sodium salt [129-18-0], and a combination of the latter and aminopyrine (II) [58-15-1] were cytotoxic at concentrations higher than those which were virustatic. Sodium salicylate and I were active only 1-4 hr after infection, or after adsorption and penetration of the virus through the cellular membrane.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Actions of anti-inflammatory drugs on smooth muscle.Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The concentration-dependent relaxation of guinea pig tracheal muscle for a number of antiinflammatory drugs such as phenylbutazone Na salt (I) [129-18-0] was demonstrated. The concentration-response curves obtained with these drugs were parallel, and the progressive decrease in tone of tracheal muscle appeared to be due to the inhibition of prostaglandin synthesis.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analytical study of phenylbutazone》. Authors are Breugelmans, J. G.; Braun, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A review of tests, standards, and assay procedures for phenylbutazone (I) and its Na salt. Adapted methods are given for the determination of I in binary association with antipyrine, aminopyrine, phenacetin, novalgin, aspirin, atophan, caffeine, medonine, and quaternary mixtures in suppositories containing I, aminopyrine, medonine, codeine phosphate, and neutral fat.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Solberg, Claus O.; Allred, Craig D.; Hill, Harry R. researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Influence of phenylbutazone on leukocyte chemiluminescence and function》 about this compound( cas:129-18-0 ) in Acta Pathologica et Microbiologica Scandinavica, Section C: Immunology. Keywords: phenylbutazone leukocyte chemiluminescence. We’ll tell you more about this compound (cas:129-18-0).

The effect of Na phenylbutazone (I Na salt) [129-18-0] on human leukocyte chemiluminescence, phagocytosis and intracellular killing of bacteria was examined A marked reduction of chemiluminescence and intracellular killing of bacteria was observed The effect on phagocytosis was less pronounced. High drug concentrations nearly abolished light emission, and concentrations equivalent to those obtained in plasma during therapy caused a 25-30% reduction The effect occurred within less than 10 min after I administration. No permanent effect upon resting cells was observed I reduced the effect of Na azide on leukocyte chemiluminescence, indicating that the drug might also inhibit myeloperoxidase dependent chemiluminescence. Whether these impairments of leukocyte function also take place in vivo resulting in enhanced susceptibility to infection remains unknown.

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Category: benzofurans. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about The effect of bradykinin and anti-inflammatory agents on isolated arteries. Author is Starr, M. S.; West, Geoffrey Buckle.

All artery preparations (pulmonary, ear, femoral, mesenteric, brachial, and carotid arteries) from guinea pigs were constricted by bradykinin (0.1-10 γ), but only those of the pulmonary vessels of the rat and rabbit responded in this way. The vasoconstrictor action of bradykinin on the isolated mammalian arteries was antagonized by Na phenylbutazone, Na mefenamate, Na flufenamate, Na meclofenamate, and Ca acetylsalicylate when the latter were administered by slow infusion (0.1-2.5 mg./min.) However, the same concentrations of the antagonists also antagonized the vasoconstrictor responses to histamine, 5-hydroxytryptamine, acetylcholine, noradrenaline, and kallidin, thus indicating that the antagonism was nonspecific.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antianaphylactic activity of pyrazolone derivatives in the rabbit》. Authors are Lecomte, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Intravenous injection of 1,5-dimethyl-2-phenyl-3-pyrazolone (antipyrine), 4-dimethylamino-1,5-dimethyl-2-phenyl-3-pyrazolone (pyramidon), Na (antipyrinylmethylamino)methanesulfonate (Noval-gin), or 4-butyl-1-phenyl-3,5-dioxopyrazolidine piperazine salt (I) (all at 10 mg./kg.) into rabbits produced a decrease in blood pressure of 1-2 cm., which lasted for 2 min. A similar injection of phenylbutazone II, 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine piperazine salt (III), or irgapyrine (a 1:1 mixture of pyramidon and phenylbutazone) produced a hypotension of 2-4 cm.; II produced generalized convulsions in some rabbits. Intravenous injection of II or III; irgapyrine; pyramidon, antipyrine, or Novalgin; or I (in order of decreasing activity) (all at 100 mg./kg.) suppressed or reduced arterial hypotension during anaphylactic shock in rabbits previously sensitized with egg white albumin. Only the diphenyl derivatives of pyrazolone completely suppressed the hypotension, which was often replaced by hypertension; this latter effect depends on a direct stimulation of the adrenal medulla by antigen-antibody reactions. The piperazine salt of II showed the same protective activity as the Na salt of II, while I was less active than III. Intravenous injection of 150 mg. II/kg. also showed antiallergic action in rabbits sensitized with human erythrocytes, which shows that this action is independent of the nature of the antigen. However, II did not suppress all the effects of anaphylactic shock, since the formation of clumps of erythrocytes in the blood and thrombopenia were not inhibited. The protective action of II is not directed against immunological phenomena in the plasma, but probably lies in a modification of tissue reactions during shock. 15 references.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ) is researched.Application of 129-18-0.Pawelczyk, Ewaryst; Wachowiak, Roman published the article 《Kinetics of drug decomposition. VII. Kinetics of sodium phenylbutazone hydrolysis》 about this compound( cas:129-18-0 ) in Dissertationes Pharmaceuticae et Pharmacologicae. Keywords: phenylbutazone decomposition kinetics; kinetics decomposition phenylbutazone; hydrolysis phenylbutazone. Let’s learn more about this compound (cas:129-18-0).

The decomposition rate of 0.00303M Na phenylbutazone (I) in aqueous buffer under N was 1st order. The rate was independent of kind and concentration of buffer, its ionic strength, and hydroxyl ion activity. Storage of a 20% aqueous solution of I at 20° produces a decomposition loss of 10% after 1.047 years. Concentrations of I were determined spectrophotometrically using measurements at 235 and 264 nm.

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Reference:
Benzofuran – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Maurer, T. researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Category: benzofurans.They published the article 《Predictive evaluation of the allergenic effect of drugs and dyes in experimental animals》 about this compound( cas:129-18-0 ) in Acta Pharmaceutica Technologica, Supplement. Keywords: allergy pharmaceutical dye pigment. We’ll tell you more about this compound (cas:129-18-0).

The allergenic potency of the pharmaceutical dyes tartrazine [1934-21-0], amaranth [915-67-3], erythrosine [16423-68-0], yellow orange S [2783-94-0], and indigotin [482-89-3], the pharmaceutical pigments TiO2, Fe oxide black (FeO·Fe2O3), Fe oxide red (Fe2O3), and Fe oxide yellow (Fe2O3·H2O), and of aminophenazone (I) [58-15-1] acetylsalicylic acid (II) [50-78-2], phenylbutazone (III) [50-33-9], and voltaren [15307-79-6] was determined by intradermal or epidermal provocation after a sensitizing series of intradermal applications with adjuvants to guinea pig skin. With the intradermal provocation, all the dyes elicited an allergic response; tartrazine produced the slightest response; an epidermal contact allergic reaction was observed only with indigotin. None of the pigments induced an allergic response. However, an allergic reaction was observed following the intradermal provocation with I and III. Conversion of the drugs and tartrazine to their Na salts was not a potentiating factor but rather an inhibiting factor for the induction of an allergic response. Cross-reactions were observed only between tartrazine and II.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem