So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Maurer, T. researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Category: benzofurans.They published the article 《Predictive evaluation of the allergenic effect of drugs and dyes in experimental animals》 about this compound( cas:129-18-0 ) in Acta Pharmaceutica Technologica, Supplement. Keywords: allergy pharmaceutical dye pigment. We’ll tell you more about this compound (cas:129-18-0).
The allergenic potency of the pharmaceutical dyes tartrazine [1934-21-0], amaranth [915-67-3], erythrosine [16423-68-0], yellow orange S [2783-94-0], and indigotin [482-89-3], the pharmaceutical pigments TiO2, Fe oxide black (FeO·Fe2O3), Fe oxide red (Fe2O3), and Fe oxide yellow (Fe2O3·H2O), and of aminophenazone (I) [58-15-1] acetylsalicylic acid (II) [50-78-2], phenylbutazone (III) [50-33-9], and voltaren [15307-79-6] was determined by intradermal or epidermal provocation after a sensitizing series of intradermal applications with adjuvants to guinea pig skin. With the intradermal provocation, all the dyes elicited an allergic response; tartrazine produced the slightest response; an epidermal contact allergic reaction was observed only with indigotin. None of the pigments induced an allergic response. However, an allergic reaction was observed following the intradermal provocation with I and III. Conversion of the drugs and tartrazine to their Na salts was not a potentiating factor but rather an inhibiting factor for the induction of an allergic response. Cross-reactions were observed only between tartrazine and II.
As far as I know, this compound(129-18-0)Category: benzofurans can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem