Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Histamine release inhibition in antiinflammatory mechanism.Safety of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.
Sinomenine (50 mg/kg, i.p., twice daily, increasing daily dose by 100 mg/kg for 6 days) depleted skin histamine by >80%, inhibited induced egg-white edema by 68%, and decreased the wall weight of croton oil-induced granuloma pouches in rats. Antiinflammatory drugs, sodium salicylate, aminopyrine, sodium butazolidine, cortisone, and guaiazulene, inhibited both degranulation and histamine release induced by compound 48/80 of mast cells isolated from rat peritoneal fluid, and this inhibitory action was decreased in the presence of glucose, dinitrophenol, dicumarol, and warfarin. Prevention of edema provoked by anti-rat serum was roughly correlated to the potency of degranulation-inhibiting effect of the antiinflammatory agents. Antiinflammatory agents may prevent histamine release from the tissue, mainly by inhibiting mast cell degranulation, and prevent the contraction of endothelial cells by their uncoupling activities.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem