The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antianaphylactic activity of pyrazolone derivatives in the rabbit》. Authors are Lecomte, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.
Intravenous injection of 1,5-dimethyl-2-phenyl-3-pyrazolone (antipyrine), 4-dimethylamino-1,5-dimethyl-2-phenyl-3-pyrazolone (pyramidon), Na (antipyrinylmethylamino)methanesulfonate (Noval-gin), or 4-butyl-1-phenyl-3,5-dioxopyrazolidine piperazine salt (I) (all at 10 mg./kg.) into rabbits produced a decrease in blood pressure of 1-2 cm., which lasted for 2 min. A similar injection of phenylbutazone II, 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine piperazine salt (III), or irgapyrine (a 1:1 mixture of pyramidon and phenylbutazone) produced a hypotension of 2-4 cm.; II produced generalized convulsions in some rabbits. Intravenous injection of II or III; irgapyrine; pyramidon, antipyrine, or Novalgin; or I (in order of decreasing activity) (all at 100 mg./kg.) suppressed or reduced arterial hypotension during anaphylactic shock in rabbits previously sensitized with egg white albumin. Only the diphenyl derivatives of pyrazolone completely suppressed the hypotension, which was often replaced by hypertension; this latter effect depends on a direct stimulation of the adrenal medulla by antigen-antibody reactions. The piperazine salt of II showed the same protective activity as the Na salt of II, while I was less active than III. Intravenous injection of 150 mg. II/kg. also showed antiallergic action in rabbits sensitized with human erythrocytes, which shows that this action is independent of the nature of the antigen. However, II did not suppress all the effects of anaphylactic shock, since the formation of clumps of erythrocytes in the blood and thrombopenia were not inhibited. The protective action of II is not directed against immunological phenomena in the plasma, but probably lies in a modification of tissue reactions during shock. 15 references.
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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem