Month: February 2023

Multimodal Cleavable Reporters versus Conventional Labels for Optical Quantification of Accessible Amino and Carboxy Groups on Nano- and Microparticles was written by Moser, Marko;Nirmalananthan, Nithiya;Behnke, Thomas;Geissler, Daniel;Resch-Genger, Ute. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2018.Application of 38183-12-9 This article mentions the following:

Many applications of nanometer- and micrometer-sized particles include their surface functionalization with linkers, sensor mols., and analyte recognition moieties like (bio)ligands. This requires knowledge of the chem. nature and number of surface groups accessible for subsequent coupling reactions. Particularly attractive for the quantification of these groups are spectrophotometric and fluorometric assays, which can be read out with simple instrumentation. In this respect, we present here a novel family of cleavable spectrophotometric and multimodal reporters for conjugatable amino and carboxyl surface groups on nano- and microparticles. This allows determination of particle-bound labels, unbound reporters in the supernatant, and reporters cleaved off from the particle surface, as well as the remaining thiol groups on particle, by spectrophotometry and inductively coupled optical emission spectrometry (³²S ICP-OES). Comparison of the performance of these cleavable reporters with conductometry and conventional labels, utilizing changes in intensity or color of absorption or emission, underlines the anal. potential of this versatile concept which elegantly circumvents signal distortions by scattering and encoding dyes and enables straightforward validation by method comparison. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Structural determinants of the stability of enzyme-responsive polyion complex nanoparticles targeting Pseudomonas aeruginosa’s elastase was written by Insua, Ignacio;Petit, Marion;Blackman, Lewis D.;Keogh, Robert;Pitto-Barry, Anais;O’Reilly, Rachel K.;Peacock, Anna F. A.;Krachler, Anne Marie;Fernandez-Trillo, Francisco. And the article was included in ChemNanoMat in 2018.SDS of cas: 38183-12-9 This article mentions the following:

Here, we report how the stability of polyion complex (PIC) particles containing Pseudomonas aeruginosa’s elastase (LasB) degradable peptides and antimicrobial poly(ethylene imine) is significantly improved by careful design of the peptide component. Three LasB-degradable peptides are reported herein, all of them carrying the LasB-degradable sequence -GLA- and for which the number of anionic amino acids and cysteine units per peptide were systematically varied. Our results suggest that while net charge and potential to cross-link via disulfide bond formation do not have a predictable effect on the ability of LasB to degrade these peptides, a significant effect of these two parameters on particle preparation and stability is observed A range of techniques has been used to characterize these new materials and demonstrates that increasing the charge and crosslinking potential of the peptides results in PIC particles with better stability in physiol. conditions and upon storage. These results highlight the importance of mol. design for the preparation of PIC particles and should underpin the future development of these materials for responsive drug delivery. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9SDS of cas: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Spectrofluorometric determination of alogliptin an antidiabetic drug in pure and tablet form using fluorescamine, a fluorogenic agent: application to content uniformity test was written by Derayea, Sayed M.;Gahlan, Ahmed A.;Omar, Mahmoud A.;Saleh, Gamal A.;Haredy, Ahmed M.. And the article was included in Luminescence in 2020.Related Products of 38183-12-9 This article mentions the following:

Alogliptin is an antidiabetic drug that belongs to a group called dipeptidyl peptidase-4 enzyme inhibitors. As the drug contains a primary amino group in its structure, it readily reacts with fluorescamine in slightly alk. medium (borate buffer, pH 8.8) to form a highly fluorescent product. Emission of this product was measured at 477 nm (λex = 387 nm). The linear range between the fluorescence intensity and the drug concentration was 0.1-0.5μg ml-1 with a good correlation coefficient (0.9986). Limits of detection and quantitation were 22 and 72 ng ml-1, resp. Guidelines of the International Conference for Harmonisation were followed to validate the developed method with acceptable results. Alogliptin content was determined successfully in its com. dosage form using the fluorescamine method with good recovery (98.60-101.26%). The method has excellent levels of accuracy and precision compared with the reported method as assessed using Student’s t-test and Fisher’s exact test. The method was applied successfully for the content uniformity test with high recovery and low relative standard deviation. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of pyrazolinobenzofuro[3,2-d]pyridimidines was written by Basawaraj, Raga;Goled, S. N.;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Name: 3-Aminobenzofuran-2-carboxamide This article mentions the following:

2-(2,4,6-Trimethoxyphenyl/α-naphthyl)-4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 were prepared by nucleophilic substitution of 2-(trimethoxyphenyl/α-naphthyl)-4-chlorobenzofuro[3,2-d]pyrimidines 3,4 with N₂H₄.H₂O in MeOH. The reaction of 2-substituted 4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 with Ac₂CH₂, NCCH₂CO₂Et, or AcCH₂CO₂Et in NaOEt furnished pyrazolyl- and pyrazolinylbenzofuro[3,2-d]pyrimidines. These compounds exhibited antimicrobial and anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Name: 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines and their reactions was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2007.SDS of cas: 54802-10-7 This article mentions the following:

The condensation of 3-amino-2-carboxamide (I) with various aldehydes in the presence of hydrochloric acid gave the corresponding 2-aryl-1,2,3,4-tetrahydro-4-oxobenzofuro[3,2-d]pyrimidines II (X = O; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl). Compound I was converted into the required intermediate thiocarboxamide by the reaction with phosphorus pentasulfide in anhyd pyridine. The acid-catalyzed condensation of the thiocarboxamide with various ketones afforded the anticipated 2,2-dialkyl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu), and with various aromatic aldehydes under similar conditions furnished the resp. 2-aryl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl) in good yields. The methylation of the tetrahydrothiobenzofuro[3,2-d]pyrimidines led to the formation of a product which was found to be identical with 3-aminobenzofuran-2-carbonitrile, which has already been prepared in this laboratory Compounds II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu; R¹ = H, R² = 4-OMeC₆H₄) underwent displacement by morpholine or piperidine to produce the resp. derivatives III (X = CH₂ or O). The synthesis of 1,2,3,4-tetrahydro-2-oxo-4-thiobenzofuro[3,2-d]pyrimidine (IV) and displacement of the mercapto group to produce the corresponding cyclic amine-substituted compounds was also investigated. The structures of all the compounds were well supported by spectral and anal. data. Some of the compounds exhibited moderate to appreciable antibacterial activity against S. aureus and E. coli. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7SDS of cas: 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Correction: A convenient, bio-inspired approach to the synthesis of multi-functional, stable fluorescent silica nanoparticles using poly(ethylene-imine) [Erratum to document cited in CA168:250087] was written by Bauer, Christina A.;Chi, Gregory;Likens, Olivia Q.;Brown, Sandra E.. And the article was included in Nanoscale in 2017.Category: benzofurans This article mentions the following:

The middle initial of the last author is incorrect in the published article. The correct name is “Sandra E. Brown” and the corrected list of authors for this paper is as shown. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utility of fluorescamine-based approach for highly sensitive spectrofluorimetric determination of Ceftazidime and Vancomycin in pharmaceuticals and real human plasma was written by Marzouq, Mostafa A.;Salman, Baher I.;Hussein, Samiha A.;Ali, Marwa F. B.. And the article was included in Microchemical Journal in 2019.Computed Properties of C17H10O4 This article mentions the following:

Ceftazidime pentahydrate (CEF) and Vancomycin hydrochloride (VAN) are antimicrobial drugs they are used worldwide especially in developing countries for management several diseases caused by bacterial infections especially against Pseudomonas species. From this point, ultrasensitive, simple, rapid, cost effective method was developed for assay of CEF and VAN in real human plasma. The proposed spectrofluorimetric method was achieved using fluorescamine reagent. This method based on reaction of fluorescamine reagent with primary amine moiety (aromatic and aliphatic) in CEF and VAN resp., with calibration graph from 30 to 300 ng mL^-1 and 0.5-30 ng mL^-1 was plotted under optimum conditions. The investigated method was developed and bio-anal. validated using ICH and US-FDA recommendations. The proposed method was successfully used for determination of the cited drugs in real human plasma with high percentage of recovery ranged from 95.72 ± 0.95% to 97.72 ± 2.02 and pharmaceutical formulations with percentage 101.55 ± 0.55% and 101.99 ± 0.43% for CEF and VAN resp. The study was also utilized to examine the stability of the CEF and VAN in real human plasma. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and recognition properties of tweezer-shaped anion receptors based on acylhydrazone units was written by Zou, Linbo;Pan, Dingwu;Yan, Bairen;Tan, Zan;Lu, Xinyang;Du, Huan;Bao, Xiaoping. And the article was included in Huaxue Tongbao in 2015.Application of 1646-27-1 This article mentions the following:

An indole-acylhydrazone-based tweezer-shaped anion receptor (I) was designed and synthesized, and it displayed a selective recognition for biol. important F^–, AcO^– and H₂PO₄^– (K_a > 10⁴ L/mol with a 1:1 stoichiometry) in CH₃CN containing 1 (vol)% DMSO. However, no binding interaction was observed for other anions such as Cl^–, Br^–, I^–, NO₃^–, N₃^–, HSO₄^– and ClO₄^–. Compared with 1, reference compound 2 (end groups were benzofuran) showed a decreased affinity towards the above three anions, especially for H₂PO₄^–. ¹H NMR titration experiments indicated that cooperative utilization of indole NHs and amide NHs within 1 led to it strong binding with anions. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological evaluation of benzofuro[3,2-d]pyrimidines was written by Basawaraj, Raga;Shashikanth, Goled;Hugar, M. H.;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2009.Related Products of 54802-10-7 This article mentions the following:

The reaction of 3-amino-2-benzofurancarboxamide with 3,4,5-trimethoxybenzaldehyde in presence of catalytic quantity of conc hydrochloric acid gave 2-aryl-3,4-dihydro-4-oxo-benzofuran[3,2-d]pyrimidine (I). The nucleophilic displacement reaction of the compound I with phosphorus oxychloride furnished 2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-4-chlorobenzofuro[3,2-d]pyrimidine (II). Some 2,4-disubstituted benzofuran[3,2-d]pyrimidine derivatives were prepared by the reaction of compound II with different reagents. All the synthesized compounds were characterized on the basis of IR, ¹H NMR, mass spectra and anal. data. The compounds synthesized were screened for antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of fused furans by gas-phase pyrolysis of 2-allyloxyaryl-propenoic esters was written by Black, Michael;Cadogan, J. I. G.;Mcnab, Hamish;Macpherson, Andrew D.;Roddam, V. Peter;Smith, Carol;Swenson, Helen R.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1997.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

Flash vacuum pyrolysis of 2-allyloxypropenoic esters, e.g., I, gives benzo[b]furans, e.g., II, in synthetically useful yields by sequential generation of a phenoxyl radical, cyclization and ejection of the carboxylic ester function as a free radical leaving group. The method is compatible with a range of substituents on either the benzene ring or the propenoate chain, and is particularly effective for 2-substituted benzo[b]furans. The natural products 5-methoxybenzo[b]furan and angelicin have been synthesized in three and four steps resp. from com. available starting materials by this route. Related cyclizations to give naphtho[2,1-b]furan III were complicated by competitive formation of naphtho-[2,1b]pyran-3-ones, but the yield of the required product could be optimized by the choice of the radical precursor. Annulation of a furan ring onto a thiophene is also possible by this method, but lower yields are obtained in such pyrolyzes. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem