Month: February 2023

Identification of Hydrogen Peroxide-Secreting Cells by Cytocompatible Coating with a Hydrogel Membrane was written by Liu, Yang;Sakai, Shinji;Kawa, Shogo;Taya, Masahito. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2014.Reference of 3326-34-9 This article mentions the following:

A method for identifying each cell secreting reactive oxygen species (ROS) is highly desirable to advance the understanding of the physiol. and pathol. processes attributed to extracellular ROS. Here, the authors first report a method for realizing this. The individual cells secreting hydrogen peroxide (H₂O₂), a common ROS, could be coated by a hydrogel membrane through a horseradish peroxidase-catalyzed reaction consuming H₂O₂ secreted from the cells themselves. This hydrogel membrane coating is cytocompatible. In addition, the hydrogel membrane made from an alginate derivative could be removed on demand without causing damage to the enclosed cells. These results demonstrated the feasibility of the proposed method to be an effective tool in cellular ROS studies. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Reference of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cationic Rh(I) Catalyst in Fluorinated Alcohol: Mild Intramolecular Cycloaddition Reactions of Ester-Tethered Unsaturated Compounds was written by Saito, Akio;Ono, Takamitsu;Hanzawa, Yuji. And the article was included in Journal of Organic Chemistry in 2006.Name: 5-Methylisobenzofuran-1(3H)-one This article mentions the following:

In fluorinated alcs., the cationic Rh(I) species, which is derived from [Rh(COD)Cl]₂ and AgSbF₆, efficiently catalyzed intramol. [4+2] cycloaddition reactions of ester-tethered 1,3-diene-8-yne derivatives The catalytic system was also effective in intramol. [5+2] cycloaddition reactions of ester-tethered ω-alkynyl vinylcyclopropane compounds In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Name: 5-Methylisobenzofuran-1(3H)-one).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: 5-Methylisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Multicolor FRET Silica Nanoparticles by Single Wavelength Excitation was written by Wang, Lin;Tan, Weihong. And the article was included in Nano Letters in 2006.Product Details of 92557-80-7 This article mentions the following:

Fluorescent nanoparticles with multiple emission signatures by a single wavelength excitation are needed in multiplex bioanal. and mol. imaging. The authors have prepared silica nanoparticles encapsulated with three organic dyes using a modified Stoeber synthesis method. By varying the doping ratio of the three tandem dyes, fluorescence resonance energy transfer (FRET)-mediated emission signatures can be tuned to have the nanoparticles exhibit multiple colors under one single wavelength excitation. These nanoparticles are intensely fluorescent, highly photostable, uniform in size, and biocompatible. The acceptor emission of the FRET nanoparticles has generated a large Stokes shift, which implicates broad applications in biol. labeling and imaging. Mol. recognition moieties, such as biotin, can be covalently attached to the nanoparticle surface to allow for specific binding to target mols. These multicolor FRET silica nanoparticles can be used as barcoding tags for multiplexed signaling. By using these NPs, one can envision a dynamic, multicolor, colocalization methodol. to follow proteins, nucleic acids, mol. machines, and assemblies within living systems. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Product Details of 92557-80-7).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Product Details of 92557-80-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Inhibition of double-stranded RNA-induced inducible nitric oxide synthase expression by fraxinellone and sauchinone in murine microglia was written by Lee, Chang Seok;Won, Cheolhee;Yoo, Hyouna;Yi, Eun Hee;Cho, Yuri;Maeng, Jung Woo;Sung, Sang Hyun;Ye, Sang-Kyu;Chung, Myung-Hee. And the article was included in Biological & Pharmaceutical Bulletin in 2009.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one This article mentions the following:

Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) triggers a toll-like receptor 3-dependent inflammatory response that stimulates pro-inflammatory mediators in the brain. In present study, we initially examined the biol. effects of fraxinellone and sauchinone on anti-inflammatory actions in dsRNA-stimulated microglia. Both compounds inhibited dsRNA-induced inducible nitric oxide synthase (iNOS) expression, a major pro-inflammatory enzyme. To demonstrate the mechanism of inhibitory effect on iNOS expression, we further examined the signaling pathway induced by dsRNA in microglia. Our data show that dsRNA promotes the expression of signal transducers and activators of transcription (STAT)1/3 identified as major inflammatory transcription factors as well as activates c-Jun N-terminal kinase (JNK) in an early time. Moreover, both compounds suppressed activation of JNK-STAT1/3 signaling pathway. These results suggest that an anti-inflammatory effect by fraxinellone and sauchinone is mediated via blockade of the JNK-STAT1/3-iNOS signaling pathway in viral-infected microglia. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Condensates in the PY30-1 structure, Panyu Uplift, Pearl River Mouth Basin, south China sea: evidence for hydrothermal activity associated with petroleum migration and accumulation was written by Guo, Xiaowen;He, Sheng;Liu, Keyu;Cao, Feng;Shi, Hesheng;Zhu, Junzhang. And the article was included in Journal of Petroleum Geology in 2011.Formula: C16H10O This article mentions the following:

Condensates are present in the PY30-1 structure in the Panyu Uplift, Pearl River Mouth Basin. Biomarkers and compound-specific stable carbon isotope ratios of three condensate and two source rock samples indicate that the condensates were generated by lacustrine mudstones and coals in the Oligocene Enping Formation with a minor contribution from mudstones in the Eocene Wenchang Formation. Elevated vitrinite reflectance values, high smectite-illite transformation ratios, and elevated fluid inclusion homogenization temperatures (about 100°C higher than normal borehole temperatures) point to the influence of hydrothermal fluids at the PY30-1 structure. Hydrocarbon migration was found to have occurred at the same time as hydrothermal activity. Modeling of formation pressure evolution in the Wenchang and Enping Formation source rocks in the Baiyun Depression, adjacent to the south of the Panyu Uplift, suggest that there were three episodes of overpressure release at approx. 40-37 Ma, 33-31 Ma and 16-10 Ma. Overpressure release was probably induced by uplift and erosion during the Zhuqiong, Nanhai and Dongsha phases of tectonic deformation, resp. The third episode of overpressure release coincided with the main phase of hydrocarbon migration. The accumulation of condensates at the PY30-1 structure probably followed hydrocarbon expulsion from source rocks as a result of overpressure release in the adjacent Baiyun Depression. Vertical migration into overlying reservoir rocks occurred through faults associated with a fluid diapir which is present at the core of the PY30-1 structure. The faults are pathways along which petroleum can migrate up to shallow reservoirs. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Formula: C16H10O).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Formula: C16H10O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nanofiber-Based Delivery of Therapeutic Peptides to the Brain was written by Mazza, Mariarosa;Notman, Rebecca;Anwar, Jamshed;Rodger, Alison;Hicks, Matthew;Parkinson, Gary;McCarthy, Dave;Daviter, Tina;Moger, Julian;Garrett, Natalie;Mead, Tania;Briggs, Michael;Schatzlein, Andreas G.;Uchegbu, Ijeoma F.. And the article was included in ACS Nano in 2013.Recommanded Product: H-Arg(Pbf)-OH This article mentions the following:

The delivery of therapeutic peptides and proteins to the central nervous system is the biggest challenge when developing effective neuropharmaceuticals. The central issue is that the blood-brain barrier is impermeable to most mols. Here we demonstrate the concept of employing an amphiphilic derivative of a peptide to deliver the peptide into the brain. The key to success is that the amphiphilic peptide should by design self-assemble into nanofibers wherein the active peptide epitope is tightly wrapped around the nanofiber core. The nanofiber form appears to protect the amphiphilic peptide from degradation while in the plasma, and the amphiphilic nature of the peptide promotes its transport across the blood-brain barrier. Therapeutic brain levels of the amphiphilic peptide are achieved with this strategy, compared with the absence of detectable peptide in the brain and the consequent lack of a therapeutic response when the underivatized peptide is administered. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Recommanded Product: H-Arg(Pbf)-OH).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: H-Arg(Pbf)-OH

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor was written by Yuan, Xi;Yao, Jian-Fei;Tang, Zhen-Yu. And the article was included in Organic Letters in 2017.COA of Formula: C9H5BrO3 This article mentions the following:

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li₂CO₃ as base at low temperature In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2COA of Formula: C9H5BrO3).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C9H5BrO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Crystal Violet Lactone Salicylaldehyde Hydrazone Zn(II) Complex: a Reversible Photochromic Material both in Solution and in Solid Matrix was written by Li, Kai;Li, Yuanyuan;Tao, Jing;Liu, Lu;Wang, Lili;Hou, Hongwei;Tong, Aijun. And the article was included in Scientific Reports in 2015.COA of Formula: C26H29N3O2 This article mentions the following:

Crystal violet lactone (CVL) is a classic halochromic dye which has been widely used as chromogenic reagent in thermochromic and piezochromic systems. In this work, a very first example of CVL-based reversible photochromic compound was developed, which showed distinct color change upon UV-visible light irradiation both in solution and in solid matrix. Moreover, metal complex of CVL salicylaldehyde hydrozone was facilely synthesized, exhibiting reversible photochromic properties with good fatigue resistance. It was served as promising solid material for photo-patterning. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7COA of Formula: C26H29N3O2).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C26H29N3O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Promising post-consumer PET-derived activated carbon electrode material for non-enzymatic electrochemical determination of carbofuran hydrolysate was written by Ayyalusamy, Sureshkumar;Mishra, Susmita;Suryanarayanan, Vembu. And the article was included in Scientific Reports in 2018.Product Details of 1563-38-8 This article mentions the following:

In this work, activated carbon (AC) materials, prepared from polyethylene terephthalate (PET) waste bottles were used as the sensing platform for the indirect detection of carbofuran. The morphol. and surface properties of the PET-derived AC (PET-AC) were characterized by N₂ adsorption/desorption isotherm, X-ray diffraction (XRD), field-emission scanning/transmission electron microscopy (FE-SEM/TEM) and Raman spectroscopy. The electrochem. activity of the PET-AC modified glassy carbon electrode (GCE) (PET-AC/GCE) was measured by cyclic voltammetry and amperometry. The enhanced surface area and desirable porosities of PET-AC are attributed for the superior electrocatalytic activity on the detection of carbofuran phenol, where, the proposed sensor shows low detection limit (0.03μM) and remarkable sensitivity (0.11μA μM^-1 cm^-2). The PET-AC/GCE holds high selectivity towards potentially interfering species. It also provides desirable stability, repeatability and reproducibility on detection of carbofuran phenol. Furthermore, the proposed sensor is utilized for the detection of carbofuran phenol in real sample applications. The above mentioned unique properties and desirable electrochem. performances suggest that the PET-derived AC is the most suitable carbonaceous materials for cost-effective and non-enzymic electrochem. sensor. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Product Details of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reactivity of intein thioesters: appending a functional group to a protein was written by Kalia, Jeet;Raines, Ronald T.. And the article was included in ChemBioChem in 2006.Formula: C25H15NO9 This article mentions the following:

The success of genome sequencing has heightened the demand for new means to manipulate proteins. An especially desirable goal is the ability to modify a target protein at a specific site with a functional group of orthogonal reactivity. Here, we achieve that goal by exploiting the intrinsic electrophilicity of the thioester intermediate formed during intein-mediated protein splicing. Detailed kinetic analyses of the reaction of nitrogen nucleophiles with a chromogenic small-mol. thioester revealed that the α-hydrazino acetyl group was the optimal nucleophile for attacking a thioester at neutral pH to form a stable linkage. A bifunctional reagent bearing an α-hydrazino acetamido and azido group was synthesized in high overall yield. This reagent was used to attack the thioester linkage between a target protein and intein, and thereby append an azido group to the target protein in a single step. The azido protein retained full biol. activity. Furthermore, its azido group was available for chem. modification by Huisgen 1,3-dipolar azide-alkyne cycloaddition Thus, the mechanism of intein-mediated protein splicing provides the means to install a useful functional group at a specific site-the C terminus-of virtually any protein. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Formula: C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem