Day: January 5, 2023

Trypanocidal diamidines with four rings in one or two ring systems was written by Dann, Otto;Volz, Gerda;Demant, Ekke;Pfeifer, Wolfgang;Bergen, Gerhard;Fick, Helmut;Walkenhorst, Ekkehard. And the article was included in Justus Liebigs Annalen der Chemie in 1973.Reference of 38220-75-6 This article mentions the following:

The amidinobenzothienoindole I [R = C(:N+H2)NH2 Cl-] was prepared by reaction of 3-acetoxy-5-bromobenzo-[b]thiophene with 3-BrC6H4NHNH2 and converting the resulting bromide I (R = Br) via the nitrile I (R = CN). The hexahydrochrysene II [R = C(:N+H2)NH2Cl-, X = H2] was prepared starting from its dioxo analog II (R = H, X = O) by nitration via the dinitro compound II (R = NO2, X = O) and appropriate conversions. Similarly prepared was the hexadehydro analog of II. The benzofuranylindoles III [R = C(:N+H2)NH2Cl-, x = 5 or 6] were prepared by reaction of 2-acetyl-5-bromobenzofuran with y-BrC6H4NHNH2 (y = 3 or 4), cyclization of the resulting hydrazone, and conversion of R = Br into R = C(:N+H2)NH2Cl-. The naphthylbenzothiophene IV [R = C(:N+H2)NH2Cl-] was prepared by ring closure of 3-RC6H4SCH2COX1Br (R = Me, X1 = 2,6-naphthylene) via IV (R = CN). Similarly, the naphthothiophene V was prepared by ring closure of BrX1SCH2COC6H4Br-4. The bis(benzofuranyl)methane VI [Z = CH2, X = X1 = O, R = C(:N+H2)NH2C1-, R1 = H] was prepared by reaction of 2-(2-bromoacetyl)-5-bromobenzofuran with 5,2-Br(HO)C6H3CHO and reduction of the keto groups. Wittig reaction led to the analogs VI (Z = CH:CH, CH:CMe, CH2CH2, or CH2CHMe; X, X1 = O or S; R1 = H or Me). The trypanocidal properties of the diamidines are impaired due to the rigidity of the skeleton and its enlargement. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Reference of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-catalyzed carbonylative synthesis of quinazolinones from 2-aminobenzamide and aryl bromides was written by Wu, Xiao-Feng;He, Lin;Neumann, Helfried;Beller, Matthias. And the article was included in Chemistry – A European Journal in 2013.Application of 54802-10-7 This article mentions the following:

A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamides and bromobenzenes was developed. Various quinazolinones were produced in moderate to excellent yields under identical reaction conditions. Remarkably, all of the products were purified by simple filtration or recrystallization, and no chromatog. was needed. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ketocoumarins. A new class of triplet sensitizers was written by Specht, Donald P.;Martic, Peter A.;Farid, Samir. And the article was included in Tetrahedron in 1982.Product Details of 1646-27-1 This article mentions the following:

Derivatives of 3-ketocoumarins, e.g. I and II, were prepared by standard methods and showed the photophys. criteria of efficient triplet sensitizers. The ketocoumarins, with absorption maximum at 330-450 nm, have extinction coefficients of 10⁴-10⁵, which is an important criterion for efficient sensitization of thin films of polymers in photoresists and lithog. The singlet-triplet intersystem crossing (isc) efficiencies of several derivatives were âˆ?, whereas in others a radiationless decay process competes with the isc, and is dominant in asym. substituted derivatives The triplet energies of the ketocoumarins were 48-60 kcal/mol. The phosphorescence spectra of some ketocoumarins show the presence of “frozen-in” rotamers. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Product Details of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antimicrobial activity of new heterocyclic compound containing 5-bromobenzofuran was written by Baaiu, Basma Saad;Abdelsalam, Mansour. And the article was included in Journal of Modern Chemistry & Chemical Technology in 2020.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Several pyridine derivatives were synthesized via reaction of 2-acetyl 5-bromobenzofuran and 1,3-diphenyl-1 H-pyrazole-4-carbaldehyde gave chalcone which was exploited as a starting material. Structures of newly synthesized derivatives were confirmed by elemental anal., spectral data, chem. transformation and alternative synthetic route whenever possible. Also, the newly synthesized derivatives were screened towards some microorganism. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Silver Clusters of Five Atoms as Highly Selective Antitumoral Agents Through Irreversible Oxidation of Thiols was written by Porto, Vanesa;Buceta, David;Dominguez, Blanca;Carneiro, Carmen;Borrajo, Erea;Fraile, Maria;Davila-Ferreira, Nerea;Arias, Iria R.;Blanco, Jose M.;Blanco, Maria C.;Devida, Juan M.;Giovanetti, Lisandro J.;Requejo, Felix G.;Hernandez-Garrido, Juan C.;Calvino, Jose J.;Lopez-Haro, Miguel;Barone, Giampaolo;James, Andrew M.;Garcia-Caballero, Tomas;Gonzalez-Castano, Diego M.;Treder, Martin;Huber, Wolfgang;Vidal, Anxo;Murphy, Michael P.;Lopez-Quintela, M. Arturo;Dominguez, Fernando. And the article was included in Advanced Functional Materials in 2022.Related Products of 76-54-0 This article mentions the following:

Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 â‰?H2O2 < OH·. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state to mimic conditions within cancer cells through the expression of an activated oncogene (HRASG12V) or through ARID1A mutation, sensitizes cells to Ag5 mediated apoptosis. While cancers evolve to evade treatments designed to target pathways or genetic mutations that drive them, they cannot evade a treatment that takes advantage of aberrant redox homeostasis, which is essential for tumor progression and metastasis. Ag5 has antitumor activity in mice with orthotopic lung tumors reducing primary tumor size, and the burden of affected lymphatic nodes. The findings suggest the unique intracellular redox chem. of Ag5 may lead to new redox-based approaches to cancer therapy. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Comparative studies of synthesis of symmetric 2,6-di(benzofuran-2-yl)-4-phenylpyridine derivatives via pyrylium tetrafluoroborate salt and 1,5-dione derivatives was written by Kumar, D. B. Aruna;Desai, Nivedita R.;Krishnaswamy, G.;Sreenivasa, S.;Mahadevan, K. M.. And the article was included in Indian Journal of Chemistry in 2015.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Two pathways for the synthesis of sym. 2,6-di(benzofuran-2-yl)-4-arylpyridines I (R¹ = H, Br; R² = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄) from the corresponding 5-R¹-substituted 2-acetylbenzofurans and aromatic aldehydes R²CHO were evaluated. In the method A, boron trifluoride etherate-assisted condensation of acetylbenzofurans with aldehydes gave the corresponding 4-aryl-2,6-bis(benzofuranyl)pyrylium tetrafluoroborates which were converted in the compounds I by ring opening/recyclization in the presence of ammonium acetate at room temperature In the method B, grinding the reactants under basic conditions in the minimal amount of MeCN afforded the corresponding 1,5-di(benzofuranyl)-3-arylpentane-1,5-diones which reacted with ammonium acetate in acetic acid under reflux to give the compounds I. The method B proceeded under mild reaction conditions in a shorter reaction time and generally provided higher product yields compared to the method A. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

JNK/p66Shc/ITCH signaling pathway mediates angiotensin II-induced ferritin degradation and labile iron pool increase was written by Borkowska, Andzelika;Popowska, Urszula;Spodnik, Jan;Herman-Antosiewicz, Anna;Wozniak, Michal;Antosiewicz, Jedrzej. And the article was included in Nutrients in 2020.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Angiotensin II (Ang II) induces deleterious changes in cellular iron metabolism and increases the generation of reactive oxygen species. This leads to an impairment of neuronal and vascular function. However, the mechanism underpinning Ang II-induced changes in iron metabolism is not known. We hypothesized that Ang II-induced ferritin degradation and an increase in the labile iron pool are mediated by the c-Jun N-terminal kinase (JNK)/p66Shc/ITCH signaling pathway. We show that Ang II treatment induced ferritin degradation in an endothelial cell lines derived from the bovine stem pulmonary artery (CPAE), human umbilical vein endothelial cells (HUVEC), and HT22 neuronal cells. Ferritin degradation was accompanied by an increase in the labile iron pool, as determined by changes in calcein fluorescence. The JNK inhibitor SP600125 abolished Ang II-induced ferritin degradation Furthermore, the effect of Ang II on ferritin levels was completely abolished in cells transfected with vectors encoding catalytically inactive variants of JNK1 or JNK2. CPAE cells expressing inactive ITCH or p66Shc (substrates of JNK kinases) were completely resistant to Ang II-induced ferritin degradation These observations suggest that Ang II-induced ferritin degradation and, hence, elevation of the levels of highly reactive iron, are mediated by the JNK/p66Shc/ITCH signaling pathway. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescamine-based fluorophore for spectrofluorimetric determination of heptaminol in human plasma; application to spiked human plasma was written by Omar, Mahmoud A.;Nagy, Dalia M.;Halim, Monica E.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

An innovative approach to determine heptaminol spectrofluorimetrically was developed, determining the optimum conditions needed, then validated for determination of heptaminol in its pure form, its tablets and in spiked human plasma. The presented method is based on the reaction between fluorescamine reagent with the primary amine group found in heptaminol, using a borate buffer at pH 9.0 that yields a highly fluorescent product, fluorescence was measured at 471 nm after excitation at 393 nm. The linearity of the constructed calibration curve was (75-850 ng/mL) with LOD and LOQ values 23.85 and 72.29 ng/mL resp. The method was validated following the International Council for Harmonisation (ICH) guidelines indicating good accuracy and precision. Finally, the presented approach was adapted for in vitro study of heptaminol in spiked human plasma with a mean percentage recovery 100.52 ± 1.19% as well as in its tablets with a mean percentage recovery 99.47 ± 1.25%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of luminol-fluorescamine-PVP chemiluminescence system and its application to sensitive tyrosinase determination was written by Wang, Chao;Chen, Yequan;Snizhko, Dmytro;Du, Fangxin;Ma, Xiangui;Lou, Baohua;Li, Jianping;Xu, Guobao. And the article was included in Talanta in 2020.COA of Formula: C17H10O4 This article mentions the following:

Fluorescamine is a popular fluorescent probe. We report for the first time that luminol chemiluminescence (CL) can be enhanced by fluorescamine in the presence of PVP. The CL intensity of luminol-fluorescamine-PVP is about 26 times stronger than that of luminol. Both the removal of oxygen and the addition of superoxide dismutase (SOD) decrease CL intensity, thiourea and NaN₃ have little effect on CL intensities, indicating that O^â€?₂ is critical for CL. Interestingly, o-quinone generated from phenol by tyrosinase obviously inhibited the CL intensity. Inspired by such quenching effect on the luminol-fluorescamine-PVP CL system, a sensitive CL sensing for the determination of tyrosinase activity was developed. The method can detect tyrosinase in the range of 0.07-1.5μg mL^-1 (0.19-4.02 U mL^-1) with the detection limit of 0.035μg mL^-1 (0.094 U mL^-1). Moreover, this method exhibits satisfied recoveries for the spiked human serum samples. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aggregation-induced emission and solid fluorescence of fluorescein derivatives was written by Feng, Shumin;Gong, Shengyi;Feng, Guoqiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Formula: C20H10Cl2O5 This article mentions the following:

We report herein for the first time that the aggregation-induced emission and strong solid fluorescence of fluorescein derivatives can be realized by slightly modifying their structure, which provides a new option for AIEgens and solid fluorescent materials. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem