Silver Clusters of Five Atoms as Highly Selective Antitumoral Agents Through Irreversible Oxidation of Thiols was written by Porto, Vanesa;Buceta, David;Dominguez, Blanca;Carneiro, Carmen;Borrajo, Erea;Fraile, Maria;Davila-Ferreira, Nerea;Arias, Iria R.;Blanco, Jose M.;Blanco, Maria C.;Devida, Juan M.;Giovanetti, Lisandro J.;Requejo, Felix G.;Hernandez-Garrido, Juan C.;Calvino, Jose J.;Lopez-Haro, Miguel;Barone, Giampaolo;James, Andrew M.;Garcia-Caballero, Tomas;Gonzalez-Castano, Diego M.;Treder, Martin;Huber, Wolfgang;Vidal, Anxo;Murphy, Michael P.;Lopez-Quintela, M. Arturo;Dominguez, Fernando. And the article was included in Advanced Functional Materials in 2022.Related Products of 76-54-0 This article mentions the following:
Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 â?H2O2 < OH·. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state to mimic conditions within cancer cells through the expression of an activated oncogene (HRASG12V) or through ARID1A mutation, sensitizes cells to Ag5 mediated apoptosis. While cancers evolve to evade treatments designed to target pathways or genetic mutations that drive them, they cannot evade a treatment that takes advantage of aberrant redox homeostasis, which is essential for tumor progression and metastasis. Ag5 has antitumor activity in mice with orthotopic lung tumors reducing primary tumor size, and the burden of affected lymphatic nodes. The findings suggest the unique intracellular redox chem. of Ag5 may lead to new redox-based approaches to cancer therapy. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).
2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 76-54-0
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem