Day: January 5, 2023

Ligand-Promoted Nickel-Catalyzed para-Selective Carboxylation of Anisoles was written by Tu, Guangliang;Ju, Guodong;Ji, Shun-Jun;Zhao, Yingsheng. And the article was included in Organic Letters in 2022.Category: benzofurans This article mentions the following:

It has always been a challenge in free radical chem. to control site selectivity during the reaction of free radicals with aromatic rings. Herein, the site-selective carboxylation of anisoles through the direct reaction of the bromoform radical with a benzene ring at the para position under the assistance of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline with nickel(II) as the catalyst is reported. A wide variety of anisoles were compatible, leading to para-carboxylated products in moderate to good yields. A preliminary mechanistic study suggested that the Ni(II) complex coordinates with the methoxyl group of the aromatic ring, which may have increased the steric hindrance at the ortho and meta positions, while this weak interaction reduces the aromaticity of the aromatic ring, affording an activated Ph ring, thereby leading to highly para-selective carboxylation. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Category: benzofurans).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid and selective determination of multi-sulfonamides by high-performance thin layer chromatography coupled to fluorescent densitometry and electrospray ionization mass detection was written by Chen, Yisheng;Schwack, Wolfgang. And the article was included in Journal of Chromatography A in 2014.COA of Formula: C17H10O4 This article mentions the following:

Sulfonamides are widely used in animal husbandry and monitoring their residues in edible animal tissues is important for food safety and quality control. A simple and efficient high-performance thin-layer chromatog. (HPTLC) anal. method for rapid screening of 12 veterinary sulfonamide drugs was developed. Sample acetonitrile extracts were 10-fold concentrated and applied to HPTLC without any further cleanup. Following separation and fluram derivatization, sensitive and selective quantitation of the analytes was readily accomplished with fluorescence densitometry. Limits of detection and quantitation were 15-40 and 35-70 μg/kg, resp. Confirmative detection by HPTLC-electrospray ionization mass spectrometry (HPTLC-ESI/MS) was optimized for straightforward identification of target TLC zones to decrease the risk of potential false pos. findings. The method was validated for different matrix complexities (cow milk, pork liver and kidney). In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of a dual luciferase activity and fluorescamine protein assay adapted to a 384 micro-well plate format: Reducing variability in human luciferase transactivation cell lines aimed at endocrine active substances was written by Brennan, Jennifer C.;Tillitt, Donald E.. And the article was included in Toxicology In Vitro in 2018.SDS of cas: 38183-12-9 This article mentions the following:

There is a need to adapt cell bioassays to 384-well and 1536-well formats instead of the traditional 96-well format as high-throughput screening (HTS) demands increase. However, the sensitivity and performance of the bioassay must be re-verified in these higher micro-well plates, and verification of cell health must also be HT (high-throughput). We have adapted two commonly used human breast luciferase transactivation cell bioassays, the recently re-named estrogen agonist/antagonist screening VM7Luc4E2 cell bioassay (previously designated BG1Luc4E2) and the androgen/glucocorticoid screening MDA-kb2 cell bioassay, to 384-well formats for HTS of endocrine-active substances (EASs). This cost-saving adaptation includes a fast, accurate, and easy measurement of protein amount in each well via the fluorescamine assay with which to normalize luciferase activity of cell lysates without requiring any transfer of the cell lysates. Here we demonstrate that by accounting for protein amount in the cell lysates, antagonistic agents can easily be distinguished from cytotoxic agents in the MDA-kb2 and VM7Luc4E2 cell bioassays. Addnl., we demonstrate via the fluorescamine assay improved interpretation of luciferase activity in wells along the edge of the plate (the so-called “edge effect”), thereby increasing usable wells to the entire plate, not just interior wells. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9SDS of cas: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The CHD6 chromatin remodeler is an oxidative DNA damage response factor was written by Moore, Shaun;Berger, N. Daniel;Luijsterburg, Martijn S.;Piett, Cortt G.;Stanley, Fintan K. T.;Schrader, Christoph U.;Fang, Shujuan;Chan, Jennifer A.;Schriemer, David C.;Nagel, Zachary D.;van Attikum, Haico;Goodarzi, Aaron A.. And the article was included in Nature Communications in 2019.Related Products of 76-54-0 This article mentions the following:

Cell survival after oxidative DNA damage requires signaling, repair and transcriptional events often enabled by nucleosome displacement, exchange or removal by chromatin remodeling enzymes. Here, we show that Chromodomain Helicase DNA-binding protein 6 (CHD6), distinct to other CHD enzymes, is stabilized during oxidative stress via reduced degradation CHD6 relocates rapidly to DNA damage in a manner dependent upon oxidative lesions and a conserved N-terminal poly(ADP-ribose)-dependent recruitment motif, with later retention requiring the double chromodomain and central core. CHD6 ablation increases reactive oxygen species persistence and impairs anti-oxidant transcriptional responses, leading to elevated DNA breakage and poly(ADP-ribose) induction that cannot be rescued by catalytic or double chromodomain mutants. Despite no overt epigenetic or DNA repair abnormalities, CHD6 loss leads to impaired cell survival after chronic oxidative stress, abnormal chromatin relaxation, amplified DNA damage signaling and checkpoint hypersensitivity. We suggest that CHD6 is a key regulator of the oxidative DNA damage response. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A novel ¹⁸F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains was written by Cheng, Yan;Ono, Masahiro;Kimura, Hiroyuki;Kagawa, Shinya;Nishii, Ryuichi;Saji, Hideo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid This article mentions the following:

A potential probe for PET targeting β-amyloid plaques in Alzheimer’s disease (AD) brain, FPYBF-1 (5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine), was synthesized and evaluated. In experiments in vitro, FPYBF-1 displayed high affinity for Aβ(1-42) aggregates (K _i = 0.9 nM), and substantial labeling of β-amyloid plaques in sections of postmortem AD brains but not control brains. In experiments in vivo, [¹⁸F]FPYBF-1 displayed good initial uptake (5.16%ID/g at 2 min postinjection) and rapid washout from the brain (2.44%ID/g at 60 min postinjection) in normal mice, and excellent binding to β-amyloid plaques in a murine model of AD. Furthermore, the specific labeling of plaques labeling was observed in autoradiographs of autopsied AD brain sections. [¹⁸F]FPYBF-1 may be a useful probe for imaging β-amyloid plaques in living brain tissue. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quinoxalines. Part 13: Synthesis and mass spectrometric study of aryloxymethylquinoxalines and benzo[b]furylquinoxalines was written by Starke, Ines;Sarodnick, Gerhard;Ovcharenko, Vladimir V.;Pihlaja, Kalevi;Kleinpeter, Erich. And the article was included in Tetrahedron in 2004.COA of Formula: C10H7BrO2 This article mentions the following:

A series of new aryloxymethylquinoxalines, benzo[b]- and naphtho[2,1-b]furylquinoxalines, possessing potential biol. activity, was prepared, characterized by IR and NMR spectroscopy and their electron ionization (EI) mass spectra studied in detail. The aryloxymethylquinoxalines were obtained by reacting halogenomethylquinoxalines with bifunctional O-nucleophiles. The benzo[b]furylquinoxalines and naphtho[2,1-b]furylquinoxalines were prepared via two routes, which differed in the order of the two cyclization steps involved in the syntheses. The composition of the ions obtained by EI mass spectrometry were determined by accurate mass measurements and the fragmentation pathways clarified by B/E linked scans and collision induced dissociation The mass spectrometric behavior of the compounds studied as to the possible loss of OH^• radicals proved to be very characteristic. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6COA of Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

1-(5-Bromo-1-benzofuran-2-yl)ethanone was written by Fun, Hoong-Kun;Quah, Ching Kheng;Abdel-Aziz, Hatem A.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Related Products of 38220-75-6 This article mentions the following:

The title compound, C₁₀H₇BrO₂, is approx. planar (r.m.s. deviation = 0.057 Å for the 13 non-H atoms). In the crystal, mols. are linked via C-H···O hydrogen bonds into C(5) chains propagating in [100]. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A new cyano-substituted fluorescamine superior to its original form as a fluorescent probe for amino acid detection was written by Motoyoshiya, Jiro;Tomioka, Satoshi;Kobayashi, Daigo;Fujimoto, Tetsuya. And the article was included in Tetrahedron Letters in 2018.Synthetic Route of C17H10O4 This article mentions the following:

Synthesis and spectral study of two new cyano-substituted fluorescamine as the fluorescent probes for amino acid detection have been carried out comparing with the original fluorescamine. Of the three compounds, the derivative with a cyano group at the meta-position on the 4-Ph group was superior to the original one in the reactivity toward some amino acids as well as the fluorescence intensity of the adducts. The fluorescent amino acid adducts were also applied to the peroxyoxalate chemiluminescence system as the fluorophores, in which the derivative described above was more effective also in chemiluminescence than the original one. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of ten sulfonamides in honey using tetrahydrofuran Salting Out Liquid Liquid Extraction and monolithic silica column was written by Kadzinski, Leszek;Banasiuk, Rafal;Banecki, Bogdan. And the article was included in LWT–Food Science and Technology in 2018.Formula: C17H10O4 This article mentions the following:

This study presented a novel extraction method using acid hydrolysis and salting out liquid-liquid extraction (SALLE) using THF without the need of the cleanup or sample evaporation step, and a simple HPLC-fluorescence method with pre-column derivatization using a reverse phase C18 monolith column for detection of 10 sulfonamides in honey. Different sulfonamides such as sulfathiazole, sulfamethazine, sulfamerazine, sulfanilamide, sulfamethoxypyridazine, sulfachloropyridazine, sulfacetamide, sulfamethoxazole, sulfadimethoxine and sulfadiazine were extracted from wildflower honey samples by salting out liquid-liquid extraction with THF. Stability of derivatized sulfonamide samples were detected in different solvents like THF, methanol and citrate buffer pH 3.5. HPLC-fluorescence method developed using monolithic silica column demonstrated to be specific, because no interfering peaks were observed at the retention time of sulfonamide analytes. The author concluded that the SALLE extraction and HPLC-fluorescence method developed in this study was specific, accurate and precise over a linear dynamic range for detecting sulfonamides in honey samples. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Alternative sample treatments for the determination of sulfonamides in milk by HPLC with fluorescence detection was written by Arroyo-Manzanares, Natalia;Gamiz-Gracia, Laura;Garcia-Campana, Ana M.. And the article was included in Food Chemistry in 2014.Synthetic Route of C17H10O4 This article mentions the following:

Sample treatments by dispersive liquid-liquid microextraction (DLLME) and QuEChERS for the determination of 9 sulfonamides in milk were compared. Both sample preparation methods represent useful alternatives to conventional procedures based mainly on solid-phase extraction, in terms of simplicity, decreased use of organic solvents, sample throughput, and effectiveness in extract clean-up. The sample preparation methods were compared for efficiency, trueness, sensitivity and precision using HPLC with fluorescamine derivatization and fluorescence detection. The clean extracts were obtained with analyte recoveries 90.8-104.7 and 83.6-104.8% for DLLME and QuEChERS, resp. Matrix-matched calibration curves were established for both methods using milk samples spiked at 4 concentration levels. LODs (3xS/N) <1.21 and 2.73 μg/L for DLLME and QuEChERS, resp., were obtained in all cases. The precision, in terms of repeatability and intermediate precision, was <10% in all cases. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem