Day: January 6, 2023

Synthesis, characterisation and antibacterial activities of titanium(III) complexes with schiff bases derived from benzofuran was written by Kannojia, Poonam;Sahdev. And the article was included in Oriental Journal of Chemistry in 2011.COA of Formula: C9H8N2O2 This article mentions the following:

Titanium(III) chloride reacts with Schiff bases derived from benzaldehydes/acetophenone with 3-aminobenzofuran-2-carboxamide/ethyl 3-aminobenzofuran-2-carboxylate to yield complexes having general composition [Ti(L)₂(H₂O)₂]Cl₃ (L = Schiff base). The ligands and their corresponding Ti(III) complexes were characterized by elemental analyses, molar conductance,magnetic susceptibility, IR and electronic spectra and TGA. The ligands act in a bidentate manner. Based on these studies octahedral geometries are proposed for these complexes. The ligands and their Ti(III)complexes have screened for antibacterial activities. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7COA of Formula: C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Impaction of factors associated with oxidative stress on the pathogenesis of gestational hypertension and preeclampsia: A Chinese patients based study was written by Qiu, Dongmei;Wu, Jufei;Li, Min;Wang, Li;Zhu, Xianggan;Chen, Youguo. And the article was included in Medicine (Philadelphia, PA, United States) in 2021.Synthetic Route of C20H10Cl2O5 This article mentions the following:

We aimed to investigate the effect of Kelch-like ECH-associated protein 1/NF-E2 p45-related factor 2 (Keap1/Nrf2) pathway on the biol. function of trophoblast cells in oxidative stress model at the cellular level, and analyzed the expression level and clin. significance of Keap1/Nrf2 pathway and related antioxidant factors in placental tissues of Preeclampsia (PE) patients at clin. level. In present study, we found that under hypoxia/reoxygenation conditions, the activity of oxidative stress-related enzymes (CAT, GSH-Px, SOD) in HTR8/SVneo cells was significantly lower than that before treatment (P<01). The activities of CAT, GSH-Px and SOD in HTR8/SVneo cells in SiRNA+H/R group decreased significantly (P<01), indicating the important defense effect of Keap1/Nrf2 signaling pathway in oxidative stress. As a control group of Nrf2SiRNA+H/R group, Si-NC+H/R group had CAT, GSH-Px and SOD activities decreasing, which was similar to that in H/R group. Moreover, the activities of oxidative stress-related active enzymes in patients with PE were further confirmed by detecting and comparing the activities of CAT, GSH-Px and SOD in placental tissues. The results showed that the activity of SOD (P<001), GSH-Px (P<01) and CAT (P<01) in placental tissues of patients with PE were significant different from those of normal placental tissues. The expression level of Keap1 in placenta of patients with PE was slightly lower than that of normal placenta. While the expression of Nrf2 in placenta of patients with PE was significantly higher than that of normal placenta. HO-1 expression in placenta of patients with PE was significantly higher than that of normal placenta. These results implicate the importance of Keap-1/Nrf2 pathway in PE. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cholinergic system and exploratory behavior are changed after weekly-binge ethanol exposure in zebrafish was written by Bernardo, Henrique Teza;Agostini, Jotele Fontana;Toe, Helena Cristina Zuehl Dal;Vieira, Karine Medeiros;Baldin, Samira Leila;Schuck, Patricia Fernanda;Uribe-Cruz, Carolina;Longo, Larisse;da Silveira, Themis Reverbel;Rosemberg, Denis Broock;Rico, Eduardo Pacheco. And the article was included in Pharmacology, Biochemistry and Behavior in 2019.Synthetic Route of C20H10Cl2O5 This article mentions the following:

Binge drinking is characterized by excessive alc. consumption in a short period of time and is associated with a poor quality of life. Zebrafish are commonly used to investigate neurochem., behavioral, and genetic parameters associated with ethanol (EtOH) exposure. However, few studies have used zebrafish as a model to investigate binge EtOH exposure. In order to elucidate the potential neurobehavioral impairments evoked by binge EtOH exposure in zebrafish, animals were immersed in 1.4% EtOH for 30 min three consecutive times with intervals of one week. Neurobehavioral parameters were analyzed immediately following the third exposure, as well as 2 and 9 days later. Brain choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were reduced 9 days after the treatment. Thiobarbituric acid-reactive species and dichlorodihydrofluorescein levels were increased immediately after the treatment, but both returned to normal levels 2 days after the treatment. Catalase and glutathione reductase were impaired 2 and 9 days after the treatment. No alteration was observed in superoxide dismutase and glutathione peroxidase activities. EtOH treatment did not alter brain expression of inflammatory genes such as il-1β, il-10, and tnf-α . Zebrafish displayed anxiolytic-like behavior immediately after the last exposure, though there was no behavioral alteration observed 9 days after the treatment. Therefore, binge EtOH exposure in zebrafish leads to long lasting brain cholinergic alteration, probably related to oxidative stress immediately after the exposure, which is independent of classical inflammatory markers. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation and Properties of Cationic Gelatin Cross-Linked with Tannin was written by Yu, Ning;Li, Junying;Ma, Feng;Yang, Pengfei;Liu, Wenjie;Zhou, Mingyang;Zhu, Zhifei;Xing, Shu. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Reference of 38183-12-9 This article mentions the following:

A kind of biomaterial with antibacterial and mech. properties was prepared using gelatin (GE) as a raw material. GE was modified by antibacterial epoxy quaternary ammonium salt (QAS) and then crosslinked with tannic acid (TA). Anal. of the Fourier transform IR spectroscopy (FTIR) results showed that the cationic group was grafted onto GE by reaction of the amino of GE with the epoxy of QAS, and the crosslinking occurred between the amino of GE and the active groups of TA under alk. conditions. The crosslinking degree was determined by the fluorescence method via a derivative reaction of fluorescamin. The influence of the crosslinking degree on the phys. and chem. properties of the GE film was studied by SEM, differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), X-ray diffraction (XRD), and mech. testing. The results showed that the modified GE film formed a compact crosslinking structure, and its thermostability and mech. properties were improved with increasing crosslinking degree. The in vitro antibacterial rate of the crosslinked cationic GE film to Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) reached 95.83% and 100% resp., and the in vitro cell relative growth rate (RGR) of HeLa cells cultured in the extracted leachate of the crosslinked cationic GE film exceeded 85%, which illustrated that the modified GE film had excellent antibacterial activity and biocompatibility. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation was written by Abdelrahman, Mohamed A.;Eldehna, Wagdy M.;Nocentini, Alessio;Ibrahim, Hany S.;Almahli, Hadia;Abdel-Aziz, Hatem A.;Abou-Seri, Sahar M.;Supuran, Claudiu T.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.Category: benzofurans This article mentions the following:

Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulfonamides, featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker. All the target benzofurans were examined for their inhibitory activities toward isoforms hCA I, II, IX, and XII. The target tumor-associated hCA IX and XII isoforms were efficiently inhibited with K_Is spanning in ranges 10.0-97.5 and 10.1-71.8 nM, resp. Interestingly, arylsulfonehydrazones displayed the best selectivity toward hCA IX and XII over hCA I (SIs: 39.4-250.3 and 26.0-149.9, resp.), and over hCA II (SIs: 19.6-57.1 and 13.0-34.2, resp.). Furthermore, the target benzofurans were assessed for their anti-proliferative activity, according to US-NCI protocol, toward a panel of sixty cancer cell lines. Only benzofurans and possessed selective and moderate growth inhibitory activity toward certain cancer cell lines. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Category: benzofurans).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gas chromatographic analysis of benzofuran derivatives was written by Nakanishi, Teruo;Ito, Kiyoshi. And the article was included in Nippon Nogei Kagaku Kaishi in 1969.COA of Formula: C10H8O3 This article mentions the following:

Retention times (tr in min) of 53 benzofuran derivatives are given for 3 stationary phases at 140-300°. The columns were: (1) 5% diethylene glycol adipate on Chromosorb W, 3 mm inner diameter × 1.11 m; (2) 20% Apiezon grease L on Neosorb NC, 3 mm inner diameter × 1.11 m; (3) 10% Silicone SE-30 on Chromosorb W, 3 mm inner diameter × 0.74 m. A H flame ionization detector was used in each case. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Harmless-Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy was written by Zhou, Tian-Jiao;Xu, Yuan;Xing, Lei;Wang, Yi;Jiang, Hu-Lin. And the article was included in Advanced Materials (Weinheim, Germany) in 2021.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular hydrogen peroxide (H₂O₂) into hydroxyl radicals (OH·). Although many studies on H₂O₂ supplementation have been conducted to improve the therapeutic effect of CDT, few studies have focused on the application of superoxide radical (O₂^-·) in CDT, which may result in better efficacy. A major concern about O₂^-·-mediated CDT is its tendency to induce serious oxidative damage to normal tissues, which may be addressed by using a degradable O₂^-· scavenger. Here, a harmless-harmful switchable and uninterrupted laccase (LAC)-instructed killer (HULK) is constructed, which is the first CDT agent accelerated by LAC-instructed O₂^-· generation and possesses a harmless-harmful switchable effect because of the photodegradation of the O₂^-· scavenger iron-chlorin e6 (FeCe6). LAC-instructed substrate oxidation effectively catalyzes O₂-· production with the help of intracellular reduction, thereby promoting the conversion of Fe³⁺ to Fe²⁺, accelerating the generation of OH·, and inducing tumor cell apoptosis and necrosis. The introduced O₂-· scavenger FeCe6 is quickly photodegraded during irradiation, while LAC-instructed O₂^-· generation proceeds as before, resulting in activatable CDT. This work not only provides the first strategy for LAC-instructed O₂^-· generation but also presents new insight into activatable CDT. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers was written by Insua, Ignacio;Liamas, Evangelos;Zhang, Zhenyu;Peacock, Anna F. A.;Krachler, Anne Marie;Fernandez-Trillo, Francisco. And the article was included in Polymer Chemistry in 2016.Application of 38183-12-9 This article mentions the following:

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa’s elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimize particle size and charge, and their stability under physiol. conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trace determination of lenalidomide in plasma by non-extractive HPLC procedures with fluorescence detection after pre-column derivatization with fluorescamine was written by Khalil, Nasr Y.;Darwish, Ibrahim A.;Wani, Tanveer A.;Al-Majed, Abdel-Rahman A.. And the article was included in Chemistry Central Journal in 2013.Reference of 38183-12-9 This article mentions the following:

Background: Lenalidomide (LND) is a new potent drug used for treatment of multiple myeloma. For its pharmacokinetic studies and therapeutic monitoring, a proper anal. method was required. Results: In this study, a non extractive and simple pre-column derivatization procedures have been proposed, for the for trace determination of lenalidomide (LND) in human plasma by HPLC with fluorescence detection. Plasma samples were treated with acetonitrile for protein precipitation then treated with copper acetate to form stable complexes with the biogenic amines and mask their interference with the derivatization reaction of LND. Treated plasma samples containing LND was derivatized with fluorescamine (FLC) in aqueous media at ambient temperature Separation of the derivatized LND was performed on Hypersil BDS C18 column (250 × 4.6 mm, 5 μm particle size) using a mobile phase consisting of phosphate buffer (pH 4):methanol:tetrahydrofuran (70:10:20, volume/volume) at a flow rate of 1.0 mL/min. The derivatized samples were monitored at an emission wavelength of 495 nm after excitation at a wavelength of 382 nm. Under the optimum chromatog. conditions, a linear relationship with good correlation coefficient (r = 0.9997, n = 9) was found between the peak area and LND concentrations in the range of 2-100 ng/mL. The limits of detection and quantitation were 0.8 and 2.30 ng/mL, resp. The intra- and inter-assay precisions were satisfactory and the accuracy of the method was proved. The recovery of LND from the spiked human plasma was 99.30 ± 2.88. Conclusions: The proposed method had high throughput as the anal. involved simple sample pre-treatment procedure and a relatively short run-time (<15 min). The results demonstrated that the method would have a great value when it is applied in the therapeutic monitoring and pharmacokinetic studies for LND. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utility of experimental design in pre-column derivatization for the analysis of tobramycin by HPLC-fluorescence detection: application to ophthalmic solution and human plasma was written by El-Zaher, Asmaa A.;Mahrouse, Marianne A.. And the article was included in Analytical Chemistry Insights in 2013.Formula: C17H10O4 This article mentions the following:

A novel, selective, and sensitive reversed phase high-performance liquid chromatog. (HPLC) method coupled with fluorescence detection was developed for the determination of tobramycin (TOB) in pure form, in ophthalmic solution, and in spiked human blood plasma. Since TOB lacks UV absorbing chromophores and native fluorescence, pre-column derivatization of TOB was carried out using fluorescamine reagent (0.01%, 1.5 mL) and borate buffer (pH 8.5, 2 mL). Exptl. design was applied for optimization of the derivatization step. The resulting highly fluorescent stable derivative was chromatographed on C₁₈ column and eluted using MeOH:water (60:40, volume/volume) at a flow rate of 1 mL min^-1. A fluorescence detector (λ_ex 390, and λ_em 480 nm) was used. The method was linear over the concentration range 20-200 ng mL^-1. The structure of the fluorescent product was proposed, the method was then validated and applied for the determination of TOB in human plasma. The results were statistically compared with the reference method, revealing no significant difference. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem