Preparation and Properties of Cationic Gelatin Cross-Linked with Tannin was written by Yu, Ning;Li, Junying;Ma, Feng;Yang, Pengfei;Liu, Wenjie;Zhou, Mingyang;Zhu, Zhifei;Xing, Shu. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Reference of 38183-12-9 This article mentions the following:
A kind of biomaterial with antibacterial and mech. properties was prepared using gelatin (GE) as a raw material. GE was modified by antibacterial epoxy quaternary ammonium salt (QAS) and then crosslinked with tannic acid (TA). Anal. of the Fourier transform IR spectroscopy (FTIR) results showed that the cationic group was grafted onto GE by reaction of the amino of GE with the epoxy of QAS, and the crosslinking occurred between the amino of GE and the active groups of TA under alk. conditions. The crosslinking degree was determined by the fluorescence method via a derivative reaction of fluorescamin. The influence of the crosslinking degree on the phys. and chem. properties of the GE film was studied by SEM, differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), X-ray diffraction (XRD), and mech. testing. The results showed that the modified GE film formed a compact crosslinking structure, and its thermostability and mech. properties were improved with increasing crosslinking degree. The in vitro antibacterial rate of the crosslinked cationic GE film to Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) reached 95.83% and 100% resp., and the in vitro cell relative growth rate (RGR) of HeLa cells cultured in the extracted leachate of the crosslinked cationic GE film exceeded 85%, which illustrated that the modified GE film had excellent antibacterial activity and biocompatibility. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).
4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38183-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem