Day: January 4, 2023

Spectrofluorimetry – cloud point extraction determination of trace arsenic (III) with 2′,7′-dichlorofluorescein was written by Abbas, Ahmed S.. And the article was included in Journal of Physics: Conference Series in 2019.Product Details of 76-54-0 This article mentions the following:

In this work, explains a separation and Preconcentration procedure for the determination of arsenic (III) by spectrofluorimetric method after complexation with the 2′,7′-dichlorofluorescein as a fluorogenic reagent agent presence by the nonionic surfactant Triton X-114 in λex 271 nm and λ em 537 nm, after that, the quant. isolated into a unimportant volume of the surfactant-rich phase later a centrifugation. The optimum conditions, such as pH, volume of surfactant and reagent (TritonX-114), equilibrium temperature and incubation time on the cloud point extraction procedure, were studied and optimized on the extraction productivity percentage. In this method limits of detection and quantification LOD and LOQ of As(III) ion was (0.102) and (0.525) ng/mL resp., and a linear calibration range of (5.0 -50.0) ng/mL for As(III). The proposed method has been successfully applied to the determination of As(III) ion in water samples with agreeable results. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Product Details of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides was written by Lu, Changhui;Gu, Yang;Wu, Jiang;Gu, Yucheng;Shen, Qilong. And the article was included in Chemical Science in 2017.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of halo-substituted heteroarenes, such as pyridines, pyrimidines, quinolines, thiophenes, benzofurans, etc., were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. The reactions were conducted under mild conditions, and several common functional groups were tolerated. The current method represented the first general method for the site-specific incorporation of difluoromethyl moiety into heteroarenes. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Evidence of a peri effect in the benzofuran series was written by Belleney, Joel;Vebrel, Joel;Platzer, Nicole;Theobald, Francois. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1983.Synthetic Route of C10H8O3 This article mentions the following:

The synthesis of 2,3-dimethoxycarbonylbenzofuran, of its 4 monomethyl derivatives, and of some di- and tri-Me derivatives allowed their structural anal. by ¹³C NMR and mass spectrometry to be studied. The importance of electronic and steric interactions in these compounds is observed The crystal structure of 2,3-dimethoxycarbonyl-4-methylbenzofuran was determined from 172 independent reflections and refined to R 0.044. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effects of cryotherapy on the regeneration process and muscular mechanical properties after lacerative injury model. was written by Dos Santos Haupenthal, Daniela Pacheco;de Bem Silveira, Gustavo;Zaccaron, Rubya Pereira;Corrêa, Maria Eduarda Anastácio Borges;de Souza, Priscila Soares;Filho, Mário Cesar Búrigo;de Roch Casagrande, Laura;de Melo Cardoso, Mariana;Rigo, Flávia Karine;Haupenthal, Alessandro;Silveira, Paulo Cesar Lock. And the article was included in Scandinavian journal of medicine & science in sports in 2021.Reference of 76-54-0 This article mentions the following:

Cryotherapy is a therapeutic modality widely used for the treatment of muscle injuries to control pain and inflammatory processes. This study aimed to investigate the effects of cryotherapy on the inflammatory and oxidative stress parameters and mechanical properties of, and pain in, the skeletal muscles of rats with lacerative muscle injury. The rats were anesthetized with 4% isoflurane and subjected to gastrocnemius muscle laceration injury. After injury, all animals in the intervention groups received cryotherapy treatment for 20 minutes using plastic bags containing crushed ice. The protocol comprised three daily applications at 3-hour intervals on the day of injury, with reapplication 24 hours later. Seventy-two male Wistar rats were divided into three groups: sham, muscle injury (MI), and MI + cryotherapy (MI + cryo). Muscle mechanical properties were analyzed by mechanical tensile testing on day 7 after injury. The MI + cryo group showed reduced TNF-α, IFN-γ, and IL1β levels; elevated IL4, IL6, and IL10 levels; reduced oxidant production and carbonyl levels; and elevated sulfhydryl contents. Animals that underwent tissue cooling showed superoxide dismutase activity and glutathione levels close to those of the animals in the sham group. The MI and MI + cryo groups showed reduced values of the evaluated mechanical properties and lower mechanical thresholds compared to those of the animals from the sham group. Our results demonstrated that the proposed cryotherapy protocol reduced the inflammatory process and controlled oxidative stress but did not reverse the changes in the mechanical properties of muscle tissues or provide analgesic effects within the time frame analyzed. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

One- and Two-dimensional High-performance Thin-layer Chromatography as an Alternative Analytical Tool for Investigating Polyphenol-Protein Interactions was written by Tscherch, Kathrin;Biller, Julia;Lehmann, Mareen;Trusch, Maria;Rohn, Sascha. And the article was included in Phytochemical Analysis in 2013.COA of Formula: C17H10O4 This article mentions the following:

IntroductionPolyphenols and simple phenolic compounds are able to react with other food constituents during processing and storage. In the past, it has been shown that their reaction with proteins can lead to changes of the technofunctional or even physiol. properties of both compound classes. However, identification of specific binding sites of small mols. within a protein sequence and the corresponding conformational position is still challenging. ObjectiveInvestigating the reaction between different food proteins and phenolic compounds in alk. medium with one- and two-dimensional high-performance thin-layer chromatog. HPTLC coupled to matrix-assisted laser desorption/ionisation MALDI with time-of-flight TOF MS for analyzing the peptide profiles after tryptic digestion. Methods: After modification with phenolic compounds, protein derivatives were digested and peptides were separated with one- and two-dimensional HPTLC. Peptide profiles were detected with visible and UV wavelengths as well as with fluorescamine, ninhydrin and 2,2′-azino-bis3-ethylbenzothiazoline-6-sulfonic acid staining. In order to perform mass spectrometric measurements, peptides separated in the first dimension were analyzed by MALDI/TOF/MS. Results: Results show that the phenolic acids applied in this study show different specificity and susceptibility when modifying proteins resulting in changes of the peptide profiles, peptide quantity, polarity, UV-activity, radical-scavenging activity and mol. mass. ConclusionOne- and two-dimensional HPTLC supported by mass spectrometric detection represents an innovative, alternative tool for investigating and understanding polyphenol-protein interactions. This approach enables the identification of binding sites inside the protein chain and contributes to understanding the mechanism of polyphenol-protein interactions in vitro and in vivo. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization, antibacterial and anthelmintic activities of copper(II) complexes with benzofuran schiff bases was written by Reddy, K. Ramakrishna;Reddy, K. Madhusudan;Mahendra, K. N.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry in 2006.Electric Literature of C9H8N2O2 This article mentions the following:

Cu(II)chloride reacts with Schiff bases derived from benzaldehydes/acetophenone with 3-amino-2-benzofuran carboxamide or ethyl-3-amino-2-benzofuran carboxylate to yield polymeric complexes CuLCl₂ (L = Schiff base). The authenticity of the ligands and their complexes was established by micro anal., magnetic susceptibility, IR, electronic, ESR spectral studies and elec. conductance measurements. The ligands act as bidentate, with azomethane N and carbonyl O atom as donor sites. Probably Cu(II) complexes are polymeric with octahedral geometries. All the ligands and their metal complexes were screened for antibacterial activity against two bacteria, viz. S.aureus and E.coli. Several complexes show promising results against S.aureus. Anthelmintic activity of the ligands and the complexes was tested on earthworms. The activity is enhanced significantly on complexation. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Electric Literature of C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mentha rhizomes as an alternative source of natural antioxidants was written by Fialova, Silvia Bittner;Kurin, Elena;Trajcikova, Eva;Janosova, Lucia;Susanikova, Ivana;Tekel’ova, Daniela;Nagy, Milan;Mucaji, Pavel. And the article was included in Molecules in 2020.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Unlike its aerial parts, the underground parts of Mentha have so far been studied only marginally. By examining the polyphenolic fingerprint, the antioxidant efficacy and the mutual antioxidant behavior of mixtures of mint rhizomes, our study presents a modest contribution to addressing this gap. Firstly, we examined the composition of the mint rhizomes: Mentha × piperita cv. ‘Perpeta’ (MPP), M. longifolia (ML), and M. × villosa cv. ‘Snezna’ (MVS). Our LC-MS-DAD anal. revealed the presence of ten compounds belonging to groups of phenolic acids and flavonoids, of which the rosmarinic acid (RA) and lithospermic were most strongly represented. Secondly, we evaluated the antioxidant activity of rhizome infusions by DPPH and ABTS and on NIH/3T3 cell lines by DCFH-DA. Thirdly, we determined, examined, and explained the mutual interactions of rhizome infusions mixtures While most of the combinations acted additive, synergy was observed in ternary infusion mixtures The combinations of mint rhizomes and rosmarinic acid displayed a high dose-reduction index. This leads to beneficial dose reduction at a given antioxidant effect level in mixtures, compared to the dose of the parts used alone. So far, the pharmaceutical and food industry has not used mint rhizomes in com. products. Hence, our study draws attention to further applications of the Mentha rhizomes as a valuable alternative source of natural antioxidants. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A fluorometric assay to determine average modification rate of three kinds of PEG-rhGHs was written by Li, Jing;He, Hui;Cheng, Su-yuan;Liang, Cheng-gang. And the article was included in Yaowu Fenxi Zazhi in 2014.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

The average rate of 3 different PEG modifications of rhGH by deriving free amines with fluorescamine was determined MALDI-TOF mass spectrometry was used to detect relative mol. mass of PEG, rhGH and the conjugations to calculate the theor. rate of PEG modification. A fluorometric method was established by optimization and validation through selection of the excitation and emission wavelength, an orthogonal experiment, an interference test of free PEG and the stability study of the reaction. The theor. value of modification rate was 10%, which was validated by MALDI-TOF mass. Validation results were as below: The excitation and emission wavelengths were 390 nm and 480 nm, resp. The pH value of solution had the greatest effect on the result. PEG with low content had no effect on the result. The relative fluorescence unit was stable within the first 8 min. The actual modification rates of three different PEG-rhGHs were 8.8%, 9.8% and 9.5%, resp., which were close to the theor. value. The fluorometric derivatization method is suitable for determination of the average rate of modification for PEG-rhGH. The average modification rate of 3 kinds of PEG-rhGHs is 10%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile Homobifunctional Imidoester Modification of Advanced Nanomaterials for Enhanced Antibiotic Synergistic Effect was written by Liu, Huifang;Zou, Qingshuang;Qiao, Zhen;Jang, Yoon Ok;Koo, Bonhan;Kim, Myoung Gyu;Lee, Hyo Joo;Kim, Sung-Han;Shin, Yong. And the article was included in ACS Applied Materials & Interfaces.Computed Properties of C20H10Cl2O5 This article mentions the following:

Resistance to antibiotics because of misuse and overuse is one of the greatest public health challenges worldwide. Despite the introduction of advanced nanotechnol. in the production of antibiotics, the choice of appropriate medicines is limited due to side effects such as blood coagulation, toxicity, low efficacy, and low biocompatibility; therefore, novel nanomaterial composites are required to counter these repercussions. We first introduce a facile method for synthesizing a homobifunctional imidoester-coated nanospindle (HINS) zinc oxide composite for enhancement of antibiotic efficacy and reduction of toxicity and blood coagulation. The antibiotic efficacy of the composites is twice that of commercialized zinc nanoparticles; in addition, they have good biocompatibility, have increased surface charge and solubility owing to the covalent acylation groups of HI, and produce a large number of Zn+ ions and defensive reactive oxygen species (ROS) that effectively kill bacteria and fungi. The synergistic effect of a combination therapy with the HINS composite and itraconazole shows more than 90% destruction of fungi in treatments with low dosage with no cytotoxicity or coagulation evident in i.v. administration in in vitro and in vivo experiments Thus, HINS composites are useful in reducing the effect of misuse and overuse of antibiotics in the medical field. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis was written by Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A.. And the article was included in Catalysis Communications in 2019.Formula: C20H10Cl2O5 This article mentions the following:

Zn_1-xTi_xO NPs were efficiently synthesized using a simple solution free mechanochem. method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn_1-xTi_xO catalysts were pos. correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodol. was also extended to sulfone-fluorescein dye synthesis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem