Day: January 4, 2023

Synthesis, characterization, and anticancer activity of new benzofuran substituted chalcones was written by Coskun, Demet;Tekin, Suat;Sandal, Suleyman;Coskun, Mehmet Fatih. And the article was included in Journal of Chemistry in 2016.Recommanded Product: 38220-75-6 This article mentions the following:

A novel series of chalcones, 3-aryl-1-(5-bromo-1- benzofuran-2-yl)-2-propanones propenones I (R¹ = Br; R² = H, NO₂; R³ = H, Br, NMe₂), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized I and previously synthesized chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log IC₅₀ values of the compounds were calculated after 24-h treatment. The results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p < 0.05). In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Novel High-Throughput Assay Reveals That the Temperature Induced Increases in Transphosphatidylation of Phospholipase D Are Dependent on the Alcohol Acceptor Concentration was written by Yang, Hengzhang;Woscholski, Rudiger. And the article was included in Biomolecules in 2022.Application of 38183-12-9 This article mentions the following:

Phospholipase D reacts with alcs. or water, transphosphatidylating or hydrolyzing lipids such as phosphatidylcholine, generating phosphatidylalcs. or phosphatidic acid, resp. The enzyme has been employed in many applications making use of the transphosphatidylation reaction and the enzyme’s tolerance for organic solvents in order to synthesize natural and artificial phospholipids. Yet, its catalytic properties with respect to the transphosphatidylation reaction are not well understood. Here, we introduce a novel high-throughput assay, making use of 96-well plates, that employs Fluorescamine for the detection of transphosphatidylated amino alcs. This assay allowed to monitor the KM and VMax at different temperatures, revealing that the former will be elevated by the temperature, while the latter is increased by a combination of both temperature and alc. acceptor concentration being elevated, suggesting that increase in temperature may open up a new binding site for the alc. acceptor. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures. was written by Nagappan, Shivathmihai;Liu, Lena;Fetcho, Robert;Nguyen, John;Nishimura, Nozomi;Radwanski, Ryan E;Lieberman, Seth;Baird-Daniel, Eliza;Ma, Hongtao;Zhao, Mingrui;Schaffer, Chris B;Schwartz, Theodore H. And the article was included in Cerebral cortex (New York, N.Y. : 1991) in 2019.Product Details of 38183-12-9 This article mentions the following:

Recent evidence shows that seizures propagate primarily through supragranular cortical layers. To selectively modify these circuits, we developed a new technique using tightly focused, femtosecond infrared laser pulses to make as small as ~100 µm-wide subsurface cortical incisions surrounding an epileptic focus. We use this “laser scalpel” to produce subsurface cortical incisions selectively to supragranular layers surrounding an epileptic focus in an acute rodent seizure model. Compared with sham animals, these microtransections completely blocked seizure initiation and propagation in 1/3 of all animals. In the remaining animals, seizure frequency was reduced by 2/3 and seizure propagation reduced by 1/3. In those seizures that still propagated, it was delayed and reduced in amplitude. When the recording electrode was inside the partially isolated cube and the seizure focus was on the outside, the results were even more striking. In spite of these microtransections, somatosensory responses to tail stimulation were maintained but with reduced amplitude. Our data show that just a single enclosing wall of laser cuts limited to supragranular layers led to a significant reduction in seizure initiation and propagation with preserved cortical function. Modification of this concept may be a useful treatment for human epilepsy. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Product Details of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microwave-Assisted N-Allylation/Homoallylation-RCM Approach: Access to Pyrrole-, Pyridine-, or Azepine-Appended (Het)aryl Aminoamides was written by Novanna, Motakatla;Kannadasan, Sathananthan;Shanmugam, Ponnusamy. And the article was included in ACS Omega in 2020.Computed Properties of C9H8N2O2 This article mentions the following:

A facile and diversity-oriented approach was developed for the synthesis of pyrrole-, pyridine-, or azepine-appended (het)aryl aminoamides via the N-allylation/homoallylation-ring-closing metathesis (RCM) strategy. Microwave condition was efficiently utilized for N-allylation of (het)aryl aminoamides to synthesized di-, tri-, and tetra-allyl/homoallylated RCM substrates in good yields. All of the RCM substrates were successfully converted to resp. pyrroles, pyridines and azepines via RCM. All of the five-, six-, and seven-membered N-heterocycles were synthesized in shorter reaction times with excellent yields without isomerization products. A one-pot reaction to synthesized pyrroles without isolating corresponding RCM substrates was achieved successfully. The synthetic utility of the compoundpyrroles was demonstrated by synthesizing biaryl derivatives pyrroles under the microwave Suzuki coupling reaction condition. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Computed Properties of C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cause-and-Effect Analysis as a Tool To Improve the Reproducibility of Nanobioassays: Four Case Studies was written by Petersen, Elijah J.;Hirsch, Cordula;Elliott, John T.;Krug, Harald F.;Aengenheister, Leonie;Arif, Ali Talib;Bogni, Alessia;Kinsner-Ovaskainen, Agnieszka;May, Sarah;Walser, Tobias;Wick, Peter;Roesslein, Matthias. And the article was included in Chemical Research in Toxicology in 2020.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

One of the challenges in using in vitro data to understand the potential risks of engineered nanomaterials (ENMs) is that results often differ or are even contradictory among studies. While it is recognized that numerous factors can influence results produced by nanobioassays, there has not yet been a consistently used conceptual framework to identify key sources of variability in these assays. In this paper, we use cause-and-effect anal. to systematically describe sources of variability in four key in vitro nanobioassays: the DCF (2′,7′-dichlorofluorescein) assay, an ELISA for measuring interleukin-8, a flow cytometry assay (Annexin V/Propidium Iodide), and the Comet assay. These assays measure endpoints that can occur in cells impacted by ENMs through oxidative stress, a principle mechanism for ENM toxicity. The results from this anal. identify control measurements to test for potential artifacts or biases that could occur during conduct of these assays with ENMs. Cause-and-effect anal. also reveal addnl. measurements that could be performed either in preliminary experiments or each time the assay is run to increase confidence in the assay results and their reproducibility within and among laboratories The approach used here with these four assays can be used the support the development of a broad range of nanobioassays. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescent Sensor for Sequentially Monitoring Zinc(II) and Cyanide Anion in Near-Perfect Aqueous Media was written by Jang, Hyo Jung;Kang, Ji Hye;Lee, Misun;Lim, Mi Hee;Kim, Cheal. And the article was included in Industrial & Engineering Chemistry Research in 2018.Application of 54802-10-7 This article mentions the following:

The authors report a sensor, I, for sequentially detecting Zn²⁺ and CN^– based on fluorescence. Sensor I was prepared through the reaction of 3-aminobenzofuran-2-carboxamide with 4-diethylaminosalicylaldehyde. Sensor I1 showed a selective off-on fluorescent response toward Zn²⁺, distinguishing Zn²⁺ from Cd²⁺. The limit of I (0.35 μM) for monitoring Zn²⁺ is lower than the World Health Organization (WHO) guideline (76 μM) for water available for drinking. Importantly, sensor I could sense Zn²⁺ in living cells and aqueous media. The resulting I-Zn²⁺ complex functioned as an efficient on-off sensor for CN^–. The mechanisms of I for detecting Zn²⁺ and CN^– were explained by spectroscopic, spectrometric, and theor. studies. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease was written by Whitmore, Clayton A.;Haynes, Justin R.;Behof, William J.;Rosenberg, Adam J.;Tantawy, Mohammed N.;Hachey, Brian C.;Wadzinski, Brian E.;Spiller, Benjamin W.;Peterson, Todd E.;Paffenroth, Krista C.;Harrison, Fiona E.;Beelman, Robert B.;Wijesinghe, Printha;Matsubara, Joanne A.;Pham, Wellington. And the article was included in Pharmaceuticals in 2022.Product Details of 76-54-0 This article mentions the following:

Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiol. antioxidant cytoprotectant. Different from other antioxidants that need to breach the blood-brain barrier to enter the brain parenchyma, a specialized transporter called OCTN1 has been identified for transporting ERGO to the brain. To assess whether consumption of ERGO can prevent the progress of Alzheimer’s disease (AD) on young (4-mo-old) 5XFAD mice. Methods and materials: Three cohorts of mice were tested in this study, including ERGO-treated 5XFAD, non-treated 5XFAD, and WT mice. After the therapy, the animals went through various behavioral experiments to assess cognition. Then, mice were scanned with PET imaging to evaluate the biomarkers associated with AD using [11C]PIB, [11C]ERGO, and [18F]FDG radioligands. At the end of imaging, the animals went through cardiac perfusion, and the brains were isolated for immunohistol. Young (4-mo-old) 5XFAD mice did not show a cognitive deficit, and thus, we observed modest improvement in the treated counterparts. In contrast, the response to therapy was clearly detected at the mol. level. Treating 5XFAD mice with ERGO resulted in reduced amyloid plaques, oxidative stress, and rescued glucose metabolism Consumption of high amounts of ERGO benefits the brain. ERGO has the potential to prevent AD. This work also demonstrates the power of imaging technol. to assess response during therapy. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Product Details of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development and validation of a simple and sensitive method for quantification of levodopa and carbidopa in rat and monkey plasma using derivatization and UPLC-MS/MS was written by Junnotula, Venkatraman;Licea-Perez, Hermes. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2013.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

A simple, selective, and sensitive quant. method has been developed for the simultaneous determination of levodopa and carbidopa in rat and monkey plasma by protein precipitation using acetonitrile containing the derivatizing reagent, fluorescamine. Derivatized products of levodopa and carbidopa were separated on a BEH C18 column (2.1 mm × 50 mm; 1.7 μm particle size) using ultra high performance liquid chromatog. (UHPLC) without any further purification Tandem mass spectrometry (MS/MS) was used for detection. The method was validated over the concentration range of 5-5000 ng/mL and 3-3000 ng/mL for levodopa and carbidopa, resp. in rat and monkey plasma. Due to the poor stability of the investigated analytes in biol. matrixes, a mixture of sodium metabisulfite and hydrazine dihydrochloride was used as a stabilizer. This method was successfully utilized to support pharmacokinetic studies in both species. The results from assay validations and incurred samples re-anal. show that the method is selective, sensitive and robust. To our knowledge, this is the first UHPLC-MS/MS based method that utilizes derivatization with fluorescamine and provides adequate sensitivity for both levodopa and carbidopa with 50 μL of sample and a run time of 3.5 min. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors was written by Sleebs, Brad E.;Levit, Alla;Street, Ian P.;Falk, Hendrik;Hammonds, Tim;Wong, Ai Ching;Charles, Mark D.;Olson, Michael F.;Baell, Jonathan B.. And the article was included in MedChemComm in 2011.Computed Properties of C9H8N2O2 This article mentions the following:

A high throughput chem. screening campaign has led to the identification of 3-aminobenzo[b]thiophene-2-carboxamides as LIMK1 inhibitors. Evolution of bicyclic hits to the tricyclic 4-aminobenzothieno[3,2-d]pyrimidine, using a traditional medicinal chem. SAR guided approach, resulted in a significant increase in potency. Further elaboration has seen the 7-phenyl-4-aminobenzothieno[3,2-d]pyrimidine emerge as a LIMK1 inhibitor lead candidate. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Computed Properties of C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Altered expression and function of hepatic transporters in a rodent model of polycystic kidney disease was written by Bezencon, Jacqueline;Beaudoin, James J.;Ito, Katsuaki;Fu, Dong;Roth, Sharin E.;Brock, William J.;Brouwer, Kim L. R.. And the article was included in Drug Metabolism & Disposition in 2019.Formula: C20H10Cl2O5 This article mentions the following:

Autosomal dominant polycystic kidney disease (ADPKD) is a common form of inherited polycystic kidney disease (PKD) and is a leading cause of kidney failure. Patients with ADPKD develop fluid-filled cysts in their kidneys, and often form cysts in their liver and other organs. However, the impact of PKD on hepatic transporters has not been characterized. Therefore, this preclin. study was designed to investigate hepatic transporter expression and function in PCK compared to wild-type (WT) Sprague Dawley rats. Transporter gene expression was measured by qPCR, and protein expression was quantified by western blot and LC-MS/MS-based proteomic anal. in rat livers. Transporter function was assessed in isolated perfused livers (IPLs), and biliary and hepatic total glutathione content were measured. Protein expression of Mrp2 and Oatp1a4 was decreased 3-fold and 2.9-fold, resp., in PCK rat livers based on western blot anal. Proteomic anal. confirmed a decrease in Mrp2 and a decrease in Oatp1a1 expression (PCK/WT ratios of 0.368[plusmn]0.098 and 0.563[plusmn]0.038, resp.; mean[plusmn]SD). The biliary excretion of 5(6)-carboxy-2′,7′-dichlorofluorescein (CDF), a substrate of Oatp1a1, Mrp2, and Mrp3, was decreased 28-fold in PCK compared to WT rat IPLs. Total glutathione was significantly reduced in the bile of PCK rats. Differences in hepatic transporter expression and function may contribute to altered disposition of Mrp2 and Oatp substrates in PKD. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem