Microwave-Assisted N-Allylation/Homoallylation-RCM Approach: Access to Pyrrole-, Pyridine-, or Azepine-Appended (Het)aryl Aminoamides was written by Novanna, Motakatla;Kannadasan, Sathananthan;Shanmugam, Ponnusamy. And the article was included in ACS Omega in 2020.Computed Properties of C9H8N2O2 This article mentions the following:
A facile and diversity-oriented approach was developed for the synthesis of pyrrole-, pyridine-, or azepine-appended (het)aryl aminoamides via the N-allylation/homoallylation-ring-closing metathesis (RCM) strategy. Microwave condition was efficiently utilized for N-allylation of (het)aryl aminoamides to synthesized di-, tri-, and tetra-allyl/homoallylated RCM substrates in good yields. All of the RCM substrates were successfully converted to resp. pyrroles, pyridines and azepines via RCM. All of the five-, six-, and seven-membered N-heterocycles were synthesized in shorter reaction times with excellent yields without isomerization products. A one-pot reaction to synthesized pyrroles without isolating corresponding RCM substrates was achieved successfully. The synthetic utility of the compoundpyrroles was demonstrated by synthesizing biaryl derivatives pyrroles under the microwave Suzuki coupling reaction condition. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Computed Properties of C9H8N2O2).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C9H8N2O2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem