Synthesis, characterization, and anticancer activity of new benzofuran substituted chalcones was written by Coskun, Demet;Tekin, Suat;Sandal, Suleyman;Coskun, Mehmet Fatih. And the article was included in Journal of Chemistry in 2016.Recommanded Product: 38220-75-6 This article mentions the following:
A novel series of chalcones, 3-aryl-1-(5-bromo-1- benzofuran-2-yl)-2-propanones propenones I (R1 = Br; R2 = H, NO2; R3 = H, Br, NMe2), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized I and previously synthesized chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log IC50 values of the compounds were calculated after 24-h treatment. The results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p < 0.05). In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 38220-75-6).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 38220-75-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem