Synthesis, characterization, antibacterial and anthelmintic activities of copper(II) complexes with benzofuran schiff bases was written by Reddy, K. Ramakrishna;Reddy, K. Madhusudan;Mahendra, K. N.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry in 2006.Electric Literature of C9H8N2O2 This article mentions the following:
Cu(II)chloride reacts with Schiff bases derived from benzaldehydes/acetophenone with 3-amino-2-benzofuran carboxamide or ethyl-3-amino-2-benzofuran carboxylate to yield polymeric complexes CuLCl2 (L = Schiff base). The authenticity of the ligands and their complexes was established by micro anal., magnetic susceptibility, IR, electronic, ESR spectral studies and elec. conductance measurements. The ligands act as bidentate, with azomethane N and carbonyl O atom as donor sites. Probably Cu(II) complexes are polymeric with octahedral geometries. All the ligands and their metal complexes were screened for antibacterial activity against two bacteria, viz. S.aureus and E.coli. Several complexes show promising results against S.aureus. Anthelmintic activity of the ligands and the complexes was tested on earthworms. The activity is enhanced significantly on complexation. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Electric Literature of C9H8N2O2).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C9H8N2O2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem