Day: October 17, 2022

Chen, Wei; Liu, Chuang; Ji, Xiaoyuan; Joseph, John; Tang, Zhongmin; Ouyang, Jiang; Xiao, Yufen; Kong, Na; Joshi, Nitin; Farokhzad, Omid C.; Tao, Wei; Xie, Tian published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy》.Name: 1,3-Diphenylisobenzofuran The article contains the following contents:

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non-invasiveness and high tissue-penetrating depth. However, developing biocompatible nanomaterial-based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid-phase exfoliation strategy to obtain a new type of two-dimensional (2D) stanene-based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano-sonosensitizers, allowing a more efficient US-triggered separation of electron (e-)-hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near-IR (NIR)-mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT-enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Name: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Name: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hadi, Marym Mohammad; Nesbitt, Heather; Masood, Hamzah; Sciscione, Fabiola; Patel, Shiv; Ramesh, Bala S.; Emberton, Mark; Callan, John F.; MacRobert, Alexander; McHale, Anthony P.; Nomikou, Nikolitsa published their research in Journal of Controlled Release in 2021. The article was titled 《Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimized sonodynamic therapy in prostate cancer》.Reference of 1,3-Diphenylisobenzofuran The article contains the following contents:

Nano-formulations that are responsive to tumor-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel stimulus-responsive nanoparticulate platform for the targeted treatment of prostate cancer using sonodynamic therapy (SDT). The nanoparticles were prepared by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphyrin. The nanoparticulate formulation was characterized with respect to particle size, morphol., surface charge and singlet oxygen production during ultrasound exposure. The response of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in the tumor microenvironment of many solid tumors, was assessed. Our results showed that digestion with cathepsin B led to nanoparticle size reduction In the absence of ultrasound, the formulation exhibited greater toxicity at acidic pH than at physiol. pH, using the human prostate cells lines LNCaP and PC3 as targets. Nanoparticle cellular uptake was enhanced at acidic pH – a condition that was also associated with greater cathepsin B production Nanoparticles exhibited enhanced ultrasound-induced cytotoxicity against both prostate cancer cell lines. Subsequent proof-of-concept in vivo studies demonstrated that, when ectopic human xenograft LNCaP tumors in SCID mice were treated with SDT using the systemically-administered nanoparticulate formulation at a single dose, tumor volumes decreased by up to 64% within 24 h. No adverse effects were observed in the nanoparticle-treated mice and their body weight remained stable. The potential of this novel formulation to deliver safe and effective treatment of prostate cancer is discussed. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Reference of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Reference of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hirota, Takashi; Fujita, Hiroko; Sasaki, Kenji; Namba, Tetsuto published their research in Journal of Heterocyclic Chemistry on December 31 ,1986. The article was titled 《A novel synthesis of benzofuran and related compounds. III. The Vilsmeier reaction of phenoxyacetaldehyde diethyl acetals》.Application of 53860-74-5 The article contains the following contents:

2-Benzofurancarboxaldehydes, e.g., I (R = H, OMe; R1 = OMe, OEt, NEt2) were prepared in 15-58% yields by the Vilsmeier reaction 3,5-RR1C6H3OCH2CH(OEt)2 (II). A rare geminidiol III was isolated in one case. II were prepared in 65-91% yields by treating 3,5-RR1C6H3ONa with BrCH2CH(OEt)2. In the experiment, the researchers used 6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5Application of 53860-74-5)

6-Methoxybenzofuran-2-carbaldehyde(cas: 53860-74-5) belongs to benzofurans.Application of 53860-74-5Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cao, Changyu; Zou, Hai; Yang, Nan; Li, Hui; Cai, Yu; Song, Xuejiao; Shao, Jinjun; Chen, Peng; Mou, Xiaozhou; Wang, Wenjun; Dong, Xiaochen published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy》.SDS of cas: 5471-63-6 The article contains the following contents:

Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving addnl. therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented “”all-in-one”” Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self-replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Zhang, Rui; Liu, Changlin; Zhao, Ruoxi; Du, Yaqian; Yang, Dan; Ding, He; Yang, Guixin; Gai, Shili; He, Fei; Yang, Piaoping published an article in Journal of Colloid and Interface Science. The title of the article was 《Engineering oxygen vacancy of MoOx nanoenzyme by Mn doping for dual-route cascaded catalysis mediated high tumor eradication》.SDS of cas: 5471-63-6 The author mentioned the following in the article:

There is an urgent need to develop photosensitive nanoenzymes with better phototherapeutic efficiency through simple processes. By exploiting semiconductor catalysis and defect chem. principles, herein, a MnMoOx composite semiconductor nanoenzyme was developed to achieve a fully integrated theranostic nanoenzyme for highly efficient photo/chemo-enzyme-dynamic eradication of deep tumors. Relative to iron oxides, manganese oxides offer ideal catalytic performance under near-neutral conditions, which helps to broaden the suitable pH range of the MnMoOx nanoenzyme for antitumor therapy. Furthermore, with the assistance of glutathione depletion, Mn4+/Mo6+ was successfully converted to Mn2+/Mo5+, inhibiting the scavenging of reactive oxygen species (ROS) and promoting cycling. Therefore, MnMoOx has favorable catalase (CAT)-like activity and oxidase (OXD)-like activity in the tumor microenvironment (TME) for promoting the “”H2O2-O2-·O2-“” and “”H2O2-·OH”” cascade reactions. The abundant oxygen vacancy defects also promote the surface plasmon resonance (SPR) effect in the second near-IR (NIR-II) window of MnMoOx, which significantly enhanced its photothermal therapy (PTT) effect and catalytic activity. In detail, ROS production was significantly enhanced due to the adsorption of water and oxygen mols. by the rich oxygen vacancies of MnMoOx. MnMoOx also exhibited excellent multi-modal imaging activity (including computed tomog. (CT), magnetic resonance imaging (MRI), and photoacoustic (PA)), which can be exploited to better guide the administration of medication. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2020 ,《Lifetime and diffusion distance of singlet oxygen in air under everyday atmospheric conditions》 was published in Physical Chemistry Chemical Physics. The article was written by Wang, Kang-Kyun; Song, Sanggeun; Jung, Seung-Jin; Hwang, Jung-Wook; Kim, Min-Goo; Kim, Ji-Hyun; Sung, Jaeyoung; Lee, Jin-Kyu; Kim, Yong-Rok. The article contains the following contents:

Singlet oxygen is a toxic chem. but powerful oxidant, exploited in many chem. and biol. applications. However, the lifetime of singlet oxygen in air under atm. conditions is yet to be known. This has limited safe usage of singlet oxygen in air, despite being a strong antimicrobial agent with the unique property of relaxing to breathable oxygen after serving its purpose. Here, we solve this long-standing problem by combining exptl. and theor. research efforts; we generate singlet oxygen using a photosensitizer at a local source and monitor the time-dependent extent of singlet oxygen reaction with probe mols. at a detector, precisely controlling the detector distance from the source. To explain our exptl. results, we employ a theor. model that fully accounts for singlet oxygen diffusion, radiative and nonradiative relaxations, and the bimol. reaction with probe mols. at the detector. For all cases investigated, our model, with only two adjustable parameters, provides an excellent quant. explanation of the experiment From this anal., we extract the lifetime of singlet oxygen in the air to be 2.80 s at 23°C under 1 atm, during which time singlet oxygen diffuses about 0.992 cm. The correctness of this estimation is confirmed by a simple mean-first-passage time anal. of the maximum distance singlet oxygen can reach from the source. We also confirm the sterilization effects of singlet oxygen for distances up to 0.6-0.8 cm, depending on the bacteria strain in question, between the bacteria and the singlet oxygen source. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Ethyl 6-methoxybenzofuran-2-carboxylateOn May 26, 2015, Xue, Si-tu; Guo, Hui-fang; Liu, Mei-jie; Jin, Jie; Ju, Da-hong; Liu, Zong-ying; Li, Zhuo-rong published an article in European Journal of Medicinal Chemistry. The article was 《Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats》. The article mentions the following:

The bone morphogenetic protein 2 (BMP-2) pathway is a promising new target for the design of therapeutic agents for the treatment of low bone mass. To enrich our understanding of SAR and based on our previously concluded structure-effect relationship, 23 derivatives were prepared in this work. The synthesis, up-regulating activities on BMP-2 expression, and bone loss prevention efficacy of these compounds in rats with glucocorticoid-induced osteoporosis are presented. The bone histol. of the tested rats assessed through light microscopy showed that several compounds significantly increased the spongy bone (i.e., trabecular bone) compared with the model group and the trabecula of the groups treated with one compound was similar to that obtained with raloxifene and alfacalcidol. The compounds exhibited potential for development as anabolic agents.Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Quality Control of Ethyl 6-methoxybenzofuran-2-carboxylate) was used in this study.

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Quality Control of Ethyl 6-methoxybenzofuran-2-carboxylateBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aboraia, Ahmed S.; Yee, Sook Wah; Gomaa, Mohamed Sayed; Shah, Nikhil; Robotham, Anna C.; Makowski, Bart; Prosser, David; Brancale, Andrea; Jones, Glenville; Simons, Claire published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides》.Recommanded Product: Ethyl 6-methoxybenzofuran-2-carboxylate The author mentioned the following in the article:

A series of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides were prepared, using an efficient three- to five-step synthesis, and evaluated for their inhibitory activity against human cytochrome P450C24A1 (CYP24A1) hydroxylase. Inhibition ranged from IC50 0.3-72 μM compared with the standard ketoconazole IC50 0.52 μM, with the styryl derivative (11c) displaying enhanced activity (IC50 = 0.3 μM) compared with the standard, providing a useful preliminary lead for drug development. After reading the article, we found that the author used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Recommanded Product: Ethyl 6-methoxybenzofuran-2-carboxylate)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Recommanded Product: Ethyl 6-methoxybenzofuran-2-carboxylateBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xue, Si-tu; Zhang, Lei; Xie, Zhuo-song; Jin, Jie; Guo, Hui-Fang; Yi, Hong; Liu, Zong-ying; Li, Zhuo-rong published their research in European Journal of Medicinal Chemistry on August 15 ,2020. The article was titled 《Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model and ADME properties》.Computed Properties of C12H12O4 The article contains the following contents:

This study optimized the structure of the anti-osteoporosis compound I [R1 = H; R2 = OMe; R5 = OEt; X = O] by balancing its lipophilicity and improving its stability. Substituted benzothiophenes/benzofurans derivatives I [R1 = H; R2 = OMe; R1R2 = OCH2O; R5 = Cl, OH, OEt; X = O, S] and II [R1 = H; R2 = OMe; R1R2 = OCH2O; R3 = n-Pr, P(O)(OH)2, CH2N(CH3)2, etc.; X = O, S; Y = O, NH, NMe] which were not reported in the literature were designed and synthesized. The ovariectomized rat model of osteoporosis was selected to evaluate the therapeutic effects, compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] showed better therapeutic efficacy than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. The anti-osteoporosis activity and BMP-2 (bone morphogenetic protein-2) protein upregulation after treatment with compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] in a zebrafish osteoporosis model was verified. Compound II [R1 = H; R2 = OMe; R3 = CH2N(CH3)2, etc.; X = O; Y = NH] improved the ADME properties, therapeutic efficacy and pharmacokinetics of the drug than that of compound I [R1 = H; R2 = OMe; R5 = OEt; X = O]. Overall, the anti-osteoporosis effects of the compounds I and II of this type, preliminarily determined the target patient population, verified the mechanism of action, clarified the level of toxicity and provided preliminary ADME data was evaluated. These compounds I and II could both correct bone loss that was already occurring in patients and had broad clin. applicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Computed Properties of C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Computed Properties of C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Capture and Release of Singlet Oxygen in Coordination-Driven Self-Assembled Organoplatinum(II) Metallacycles》 was published in Journal of the American Chemical Society in 2020. These research results belong to He, Yan-Qin; Fudickar, Werner; Tang, Jian-Hong; Wang, Heng; Li, Xiaopeng; Han, Jun; Wang, Zhengping; Liu, Min; Zhong, Yu-Wu; Linker, Torsten; Stang, Peter J.. COA of Formula: C20H14O The article mentions the following:

Singlet oxygen (1O2), as an important active reagent, has found wide applications in photodynamic therapy (PDT), synthetic chem., and materials science. Organic conjugated aromatics serving as hosts to capture and release singlet oxygen have been systematically investigated over the last decades. Herein, we present a [6 + 6] organoplatinum(II) metallacycle by using ∼180° dipyridylanthracene donor and ∼120° Pt(II) acceptor as the building blocks, which enables the capture and release of singlet oxygen with relatively high photooxygenation and thermolysis rate constants The photooxygenation of the metallacycle to the corresponding endoperoxide was performed by sensitized irradiation, and the resulting endoperoxide is stable at room temperature and can be stored under ambient condition over months. Upon simple heating of the neat endoperoxide under inert atm. at 120°C for 4 h, the resulting endoperoxide can be reconverted to the corresponding parent form and singlet oxygen. The photooxygenation and thermolysis products were characterized by NMR spectroscopy and electrospray ionization time-of-flight mass spectrometric anal. D. functional theory calculations were conducted in order to reveal the frontier MO interactions and reactivity. This work provides a new material platform for singlet oxygen related promising applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem