Day: February 22, 2021

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 6-Methoxy-3-methylbenzofuran, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 29040-52-6, name is 6-Methoxy-3-methylbenzofuran. In an article£¬Which mentioned a new discovery about 29040-52-6

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 29040-52-6, help many people in the next few years.name: 6-Methoxy-3-methylbenzofuran

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2108O – PubChem

Application of 127264-14-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, molecular formula is C10H11BrO. In a Patent£¬once mentioned of 127264-14-6

PYRROLIDINE DERIVATIVES

Compounds of the formula STR1 wherein R, Y and R 1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altered motility on tone of smooth muscle, including irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 127264-14-6, and how the biochemistry of the body works.Application of 127264-14-6

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3820O – PubChem

Reference of 1563-38-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, molecular formula is C10H12O2. In a Patent£¬once mentioned of 1563-38-8

A […] composition preparation method and application of (by machine translation)

The invention discloses a […] compound, has the following structural formula: The specific preparation steps are as follows, in order to benzofuranol as raw materials, by etherification and hydrazinolysis two-step reaction to synthesize 2 – ((2, 2 – dimethyl – 2, 3 – dihydrobenzofuran – 7 – yl) oxy) acetic acid hydrazide phospholipid, 2 – (4 – (3 – fluoro – 5 – chloro-pyridine – 2 – yloxy) phenoxy) propionyl chloride with 2 – ((2, 2 – dimethyl – 2, 3 – dihydrobenzofuran – 7 – yl) oxy) acetic acid hydrazide phospholipid […] reaction for the preparation of a compound. The compounds of the invention has better herbicidal activity, particularly monocotyledonous weed herbicidal activity superior to the dicotyledonous weeds, the preparation method is simple, the yield is higher. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1563-38-8, and how the biochemistry of the body works.Reference of 1563-38-8

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2330O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 69604-00-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 69604-00-8, Name is Ethyl 5-nitrobenzofuran-2-carboxylate, molecular formula is C11H9NO5

Metal-free deoxygenation and reductive disilylation of nitroarenes by organosilicon reducing reagents

A metal-free deoxygenation and reductive disilylation of nitroarenes was achieved using N,N?-bis(trime-thylsilyl)-4,4?-bipyridinylidene (1) under mild and neutral reaction conditions, and a broad functional group tolerance was possible in this reaction. Mono-deoxygenation, giving a synthetically valuable N,O-bis(trimethylsilyl)phe-nylhydroxylamine (7a) as a readily available and safe phenylnitrene source from nitrobenzene, and double-deoxy-genation, giving N,N-bis(trimethylsilyl)anilines 8, were easily controlled by varying the amounts of 1 and reaction temperature as well as adding dibenzothiophene (DBTP). Reaction of 2-arylnitrobenzenes with 1 resulted in the formation of the corresponding carbazoles 14 via in situ-gen-erated phenylnitrene species derived by thermolysis of N,O-bis(trimethylsilyl)phenylhydroxylamines 7, followed by their subsequent intramolecular C H insertion. In addition, the intramolecular N N coupling reaction proceeded in the reduction of 2,2?-dinitrobiphenyl derivatives by 1, giving the corresponding benzo[c]cinnolines.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 69604-00-8, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 69604-00-8

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3865O – PubChem

Synthetic Route of 4265-16-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a article£¬once mentioned of 4265-16-1

Highly efficient cyclization of o-iodobenzoates with aldehydes catalyzed by cobalt bidentate phosphine complexes: A novel entry to chiral phthalides

Methyl 2-iodobenzoates 1a-c undergo cyclization reactions with various aromatic aldehydes 2a-m (RC6CHO: R = H 2a, 4-CH3, 2b, 4tBu 2c, 4-OMe 2d, 3-OMe 2e, 4-C1 2f, 4-CF3 2g, 4-CN 2h, 4-Ph 2i; benzo [d][1,3]dioxole-5-carbaldehyde (2j), 1napthaldehyde (2k), benzofuran-2- carbaldehyde (21), and isonicotinaldehyde (2m)) in the presence of [CoI2(dppe)] (dppe = l,2-bis(diphenylphosphino)ethane) and Zn powder in dry THF at 75 C for 24 h to give the corresponding phthalide derivatives 3a-m and 3q-t in good to excellent yields. Under similar reaction conditions, less reactive aliphatic aldehydes, heptanal (2n), butyraldehyde (2o), and 2-phenylacetaldehyde (2p) also underwent cyclization reactions with la to provide 3n-p, respectively, in fair to good yields. The catalytic reaction can be further extended to cinnamyl aldehyde (2q) with la to give the corresponding phthalide derivative 3u. This synthetic method is compatible with a variety of functional groups on the aryl ring of 2. The high efficiency of the cobalt catalyst containing a dppe (dppe = l,2-bis(diphenylphosphino)ethane) ligand encouraged us to investigate the asymmetric version of the present catalytic reaction by employing bidentate chiral ligands. Thus, aromatic aldehydes 2a-c, 2f, and 2 g undergo cyclization with 2-iodobenzoate (la) smoothly in the presence of [CoI2{(S,S)- dipamp}] ((S,S)-dipamp = (1S,2S)-(+)-bis[2-methoxyphenyl]phenylphosphino)ethane) and zinc powder in THF at 75 C for 24 h, giving the corresponding (S)-phthalides 4a-e in 8189 % yields with 70-98 % ee. A possible mechanism for the present catalytic reaction is proposed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4265-16-1

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H770O – PubChem

763114-25-6, Name is 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile, belongs to benzofuran compound, is a common compound. Computed Properties of C16H8FNO2In an article, once mentioned the new application about 763114-25-6.

Permanganate Oxidation of Quinoxaline and Its Derivatives

The oxidation reaction of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described.Neutral oxidation of 2-chloro- and 2,3-dichlorodioxalines 2-4 afforded the corresponding chloro- and dichloropyrazinedicarboxilic acids 13 and 14 in good yield.On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alkaline medium gave different products, with the quinoxalin-2(1H)-one (5) forming 1,4-dihydroquinoxaline-2,3-dione (9), while various substituted quinoxalin-2,3-dione derivatives (see 9-11) gave a new type of dimeric products.The structural assignments for the new compounds were based on spectroscopic data.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 763114-25-6

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4014O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 18959-30-3, name is 4,5-Difluorophthalic Anhydride, introducing its new discovery. category: benzofuran

Synthesis of novel thermosetting imide compounds having phenylethynyl carbonyl groups at both terminal ends and production of new network polymers based on the imide compounds

A novel thermosetting imide compound having a respective phenylethynyl carbonyl group at both terminal ends was newly synthesized from an acid anhydride having a phenylethynyl carbonyl group and various diamine compounds. The thermosetting behavior of the obtained novel thermosetting imide compound having phenylethynyl carbonyl groups was analyzed through differential scanning calorimetry measurements and infrared spectroscopic analysis. As a result, it became clear that a curing reaction of phenylethynyl carbonyl groups proceeds at approximately 200C and that the curing reaction thereof proceeds at a temperature that is lower by 150C or more compared with that of phenylethynyl groups. Examination of the polymerization reaction of the imide compounds having phenylethynyl carbonyl groups using model compounds revealed that a reaction that imparted an alkene C=C and polycyclic aromatic structure progressed. Moreover, a network polymer obtained from a thermosetting imide compound having respective phenylethynyl carbonyl groups at both terminal ends exhibited extremely superior heat resistance and thermal decomposition resistance. These superior thermal properties are thought to be due to the strong molecular interaction (molecular packing) that results from the polycyclic aromatic structures and alkenes produced through polymerization of the phenylethynyl carbonyl groups and to the suppression of the movement of the molecular chains.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 18959-30-3, and how the biochemistry of the body works.category: benzofuran

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2940O – PubChem

Electric Literature of 14963-96-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 14963-96-3, 4-Methoxyisobenzofuran-1,3-dione, introducing its new discovery.

Crystal structures of highly stabilized ylides: Methyl(3-methoxy,2-methoxycarbonylbenzoyl)triphenylphosphoranylideneacetate and methyl(2-methoxycarbonyl,6-nitrobenzoyl)triphenylphosphoranylideneacetate and the salt methyl(triphenylphosphoranylidene)acetate tetrafluoroborate

At lower temperatures stabilized ylides react with unsymmetrically substituted phthalic anhydrides to give two acyclic adducts. When the reactions are allowed to proceed at higher temperature enol lactones are formed. Identification of the acyclic intermediates was necessary to understand the mechanism of these Wittig reactions. The transient species trapped in the reaction with trimethyloxonium tetrafluoroborate were unambiguously identified by crystallographic methods. The crystal structures of the tetrafluoroborate salt of methyl(triphenylphosphoranylidene)-acetate (8), methyl(3-methoxy,2-methoxycarbonylbenzoyl)triphenylphosphoranylideneacetate (6beta), and methyl(2-methoxycarbonyl,6-nitrobenzoyl)triphenylphosphoranylideneacetate (7alpha) were studied by X-ray diffraction. The ionic salt (8) is monoclinic, P21/c, a = 12.640(5), b = 13.945(9), c = 14.825(6) A, beta = 125.32(3), Z = 4, and R = 0.065 (F > 5.4 sigma(F)). Crystal 6beta is monoclinic, P21/c, a = 16.391(16), b = 9.029(6), c = 19.835(19) A, beta = 116.60(6), Z = 4, and R = 0.070 (F > 4.6 sigma(F)), while crystal 7alpha is also monoclinic, P21/c, a = 9.513(5), b = 9.361(3), c = 30.908(13) A, beta = 98.42(3), Z = 4, and R = 0.057 (F > Ssigma(F)). In the BF4- salt (12), the four P – C distances are equal (1.791(5)-1.801(7) A) with identical tetrahedral angles. For the two triphenylphosphoranylideneacetate compounds, the fourth P-C(1) bond is shorter (1.762(6)-1.734(5) A) than the three P-C(Ph) bonds (avg. 1.809(5) A). The angles C(1)-P-C(Ph) are also larger (avg. 112.9(2) for 6beta and 111.9(2) for 7alpha) than the C(Ph)-P-C(Ph) angles (avg. 105.8(2) for 6beta and 106.9(2) for 7alpha). These values suggest a multiple nature for the P-C(1) bond. In the nitro derivative, the nitro and the ester groups are disordered equally in positions 2 and 6.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 14963-96-3. In my other articles, you can also check out more blogs about 14963-96-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2880O – PubChem

Synthetic Route of 18959-30-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18959-30-3, Name is 4,5-Difluorophthalic Anhydride, molecular formula is C8H2F2O3. In a Article£¬once mentioned of 18959-30-3

Novel crosslinkable epoxy resins containing phenylacetylene and azobenzene groups: From thermal crosslinking to flame retardance

Several kinds of novel flame-retardant-free and thermo-crosslinkable epoxy resins (EPs) containing azobenzene or/and phenylacetylene groups have been synthesized and characterized, and the flame retardant properties as a result of thermal crosslinking during combustion were investigated in detail. Crosslinking behaviors were tested by simultaneous thermogravimetry-differential scanning calorimetry (TGA-DSC). Thermal stabilities were investigated by thermogravimetric analysis (TGA). Flame retardance of the resulting EPs was evaluated through LOI tests, and combustion behaviors were studied via cone calorimetry and micro-combustion calorimetry (MCC), which further confirmed that flame retardance of these EPs was significantly improved, despite the absence of conventional flame retardant. Py-GC/MS analysis was used to investigate the degradation mechanism of these epoxy resins, and the results confirmed that the flame-retardant activity of epoxy resins mainly took effect in the condensed phase. The chemical constitution of the char layers were investigated by XPS and Raman spectrum. The co-crosslinking behavior between azobenzene and phenylacetylene groups was predicted and confirmed, which led to the most compact char layer, therefore resulted in the best flame retardance of these EPs.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 18959-30-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2951O – PubChem

Electric Literature of 1563-38-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, molecular formula is C10H12O2. In a Patent£¬once mentioned of 1563-38-8

Etherified 2-hydroxy-ethyl-phosphonic acid derivatives and plant growth regulating agents containing same as active ingredient

The present invention refers to new etherified hydroxy-alkyl phosphonic acid derivatives of the general formula (I) STR1 wherein R stands for 2,3-dihydro-2,2-dimethyl-benzofuran-7-yl, 4-methyl-coumarin-7-yl, 2,2,4-trimethyl-(2H)-chromen-5-yl or 2,2,4-trimethyl-(2H)-chromen-7,yl, R1 and R2 are the same or different and stand for hydrogen, C1-8 alkyl, C1-4 halogen-alkyl, C1-4 alkoxy-C1-2 alkyl, Me stands for a monovalent cation. The new compounds can be used as active ingredients of plant growth regulating agents.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1563-38-8

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2280O – PubChem