Heterocyclic Building Block-benzofuran

95333-17-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95333-17-8,Benzofuran-4-carbonitrile,as a common compound, the synthetic route is as follows.

To a solution of benzofuran-4-carbonitrile (750 mg, 4.72 mmol, 1.00 equiv) in methyl alcohol (10.0 mL) was added Boc20 (3.09 g, l4.2mmol, 3.00 equiv) and Pd/C (4.72 mmol, 10.0 w. %, 1.00 equiv). The mixture was stirred at 30 C for 24 h under hydrogen (50.0 psi). The reaction mixture was filtered and concentrated under reduced pressure to give the crude material, which was purified by column chromatography (petroleum ether / ethyl acetate = 1 / 0 to 50 / 1) to afford /er/-butyl N-( 2, 3-dihydrobenzofuran-4-ylmethyl) carbamate (140 mg, 562 pmol, 11.9% yield) as a colorless oil. 1H NMR (400MHz, CDCI3) d = 7.10 (t, J=8.0 Hz, 1H), 6.74 (dd, J=8.0, 14.0 Hz, 2H), 4.75 (br s, 1H), 4.59 (t, J=8.8 Hz, 2H), 4.28 (br d, J=5.6 Hz, 2H), 3.20 (t, J=8.8 Hz, 2H), 1.47 (s, 9H).

The synthetic route of 95333-17-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MIRATI THERAPEUTICS, INC; MARX, Matthew, Arnold; LEE, Matthew, Randolph; BOBINSKI, Thomas, P.; BURNS, Aaron, Craig; ARORA, Nidhi; CHRISTENSEN, James, Gail; KETCHAM, John, Nichael; (225 pag.)WO2019/152419; (2019); A1;,
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4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method B Benzofuran-2-carboxaldehyde (10.0 g, 68 mmol) was dissolved in methanol (70 mL) and cooled to 5 C. Sodium borohydride (2.58 g, 68 mmol) was charged portionwise at 5 C. The batch was aged at 5 C. for 40 minutes and allowed to warm to room temperature (22 C.). The reaction was judged complete by tlc (4:1 hexanes/EtOAc) and the reaction mixture was cooled to 5 C. DI water (20 mL) was charged and the solution was concentrated in vacuo. EtOAc (80 mL) was charged and the solution was washed with DI water (2*20 mL). The EtOAc layer was concentrated in vacuo to provide benzofuran-2-carbinol as an oil.

4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US6071916; (2000); A;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

SYNTHESIS EXAMPLE 7-1;To a solution of 3-iodophthalic anhydride (32.5 g) in dimethylformamide (300 mL), a solution of (2S)-I- (methylthio)propan-2-amine (15.0 g) in dimethylformamide (50 mL) was added dropwise at -100C for 3 hours, and the mixture was stirred at -100C for additional 3 hours. After addition of 40% sodium hydroxide aqueous solution (15 g), the solvent was distilled off under reduced pressure, and the crude product was dissolved in water (500 mL) and washed with diisopropyl ether. The water phase was separated, adjusted to pH 1 with concentrated hydrochloric acid and extracted with diisopropyl ether. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting crude crystal was washed with a small amount of diisopropyl ether and air-dried to obtain 3-iodo-2-{[(lS)-l-methyl-2-(methylthio)ethyl]- carbamoyl} benzoic acid (32.2 g).Melting point: 132 – 134C

28418-88-4, The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER CROPSCIENCE AG; WADA, Katsuaki; YONETA, Yasushi; GOMIBUCHI, Takuya; MURATA, Tetsuya; KUDO, Sachio; KISHIKAWA, Hidetoshi; SHIBUYA, Katsuhiko; SHIMOJA, Eiichi; EMOTO, Akira; SATO, Yoshitaka; FISCHER, Ruediger; FUNKE, Christian; ARNOLD, Christian; FRANKEN, Eva-Maria; MALSAM, Olga; SANWALD, Erich; GOeRGENS, Ulrich; ATAKA, Masashi; RECKMANN, Udo; PAULITZ, Christian; KAPFERER, Tobias; WO2010/12442; (2010); A2;,
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Benzofuran | C8H6O – PubChem

54008-77-4,54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a hot oven-dried Schlenk tube under N2 atmosphere were added Ph3Bi (0.25 mmol, 110 mg, 1.0 equiv), 2-bromobenzofuran (0.825 mmol, 163 mg, 3.3 equiv), Cs2CO3 (0.75 mmol, 244 mg, 3.0 equiv), Pd(OAc)2 (0.025 mmol, 5.6 mg, 0.1 equiv), PPh3 (0.1 mmol, 26 mg, 0.4 equiv), and NMP (3 mL) solvent. The resulting mixture was stirred in preheated oil bath at 90 C for 1 h. After the reaction is over, the mixture was cooled, quenched with dil HCl and extracted with ethyl acetate. The combined organic extract was washed with water, brine, and dried over MgSO4 and concentrated. The crude was subjected to silica gel column chromatography (230-400 mesh) using petroleum ether as the eluent to obtain the pure 2-phenylbenzofuran (2.1) as a white solid (140 mg, 96%). The product was characterized by spectroscopy and in comparison with the literature data.

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rao, Maddali L.N.; Awasthi, Dheeraj K.; Talode, Jalindar B.; Tetrahedron Letters; vol. 53; 21; (2012); p. 2662 – 2666;,
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24410-59-1, 5-Fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of substrate 1 (1.0 mmol, 1 equiv), NaSO2CF2Br (23.4 mg, 2.0 mmol, 2.0 equiv) in CH2Cl2 (7.0 mL) and CH3CN (3.5 mL) at room temperature was slowly added TBHP (5.0-6.0 M in decane, 1.4 mL, 7 equiv). The reaction was then stirred for 16 h. After the reaction was complete, the reaction mixture was concentrated under vacuum and the crude product was purified by column chromatography on silica gel to give the product.

24410-59-1, As the paragraph descriping shows that 24410-59-1 is playing an increasingly important role.

Reference£º
Article; Zhang, Jin; Xu, Xiu-Hua; Qing, Feng-Ling; Tetrahedron Letters; vol. 57; 22; (2016); p. 2462 – 2464;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (5-Chloro-7-fluoro-1H-indole-2-yl)-carboxylic acid (5a) (50 mg, 0.23 mmol), N,N-diisopropylethylamine (82 mul, 0.47 mmol) and 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (89 mg, 0.23 mmol) were dissolved in 550 mul N,N-dimethylformamide. After stirring for 10 min 4-methyl-piperazin 6a (26 mul, 0.23 mmol) was added and the reaction mixture was stirred for 16 h at 20 C. The solvent was evaporated under reduced pressure and the crude product was purified using chromatography method P1, yielding 37 mg (53%) of the title compound., 10242-10-1

As the paragraph descriping shows that 10242-10-1 is playing an increasingly important role.

Reference£º
Article; Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 660 – 668;,
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Benzofuran | C8H6O – PubChem

69999-16-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 6 alpha-Sulfo(2,3-dihydro-5-benzofuranyl)acetic acid The title compound is prepared by a modification of the procedure described in J. Am. Chem. Soc., 75, 1653 (1953). To a solution of ethylene chloride is added about 15 mmole of the dioxane-sulfur trioxide reagent and the temperature of the mixture warms to room temperature. (2,3-Dihydro-5-benzofuranyl)acetic acid (10 mmole) is added over a period of 30 minutes. The solution is stirred overnight at room temperature and then poured into cold water. The organic layer is separated and extracted with water. The aqueous extracts are combined with the water layer which is neutralized with sodium hydroxide and evaporated to dryness. The residue is extracted with 70% ethanol. Concentrating the alcohol solution and subsequent cooling gives the sodium salt of alpha-sulfo(2,3-dihydro-5-benzofuranyl)acetic acid.

The synthetic route of 69999-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Richardson-Merrell Inc.; US4138397; (1979); A;,
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Benzofuran | C8H6O – PubChem

7168-85-6, 7-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TIPS-EBX (8, 342 mg, 0.800 mmol, 2.0 equiv), AuCl (4.6 mg,0.020 mmol, 0.050 equiv), Zn(OTf)2 (289 mg, 0.800 mmol, 2.0 equiv) and benzofuran derivatives 7 (0.40 mmol, 1.0 equiv) were added into CH3CN (2.0 mL) under air. The mixture was stirred for 26 hours at 60 C. Then the mixture was concentrated with silica gel and purified by column chromatography directly., 7168-85-6

The synthetic route of 7168-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Yifan; Waser, Jerome; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1763 – 1767;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

230642-84-9, 4-Vinyl-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the isolated Ru/salen/pyridine (4 mg, 0.005 mmol) catalyst was charged 4-vinyl-2,3-dihydrobenzofuran (0.37 g, 2.53 mmol) in 4.44 mL of toluene. To the stirred solution was slowly added a solution of EDA (0.32 g, 2.80 mmol) in 1.0 mL of toluene over 30 minutes. After 2.5 hours, an aliquot was removed, and the sample was analyzed by in-process HPLC. The desired cyclopropane ethyl ester was not formed, and only VBF was detected. The catalyst was not active in the promotion of the cyclopropanation of VBF., 230642-84-9

230642-84-9 4-Vinyl-2,3-dihydrobenzofuran 11446416, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; R.P. Scherer Technologies, Inc.; US2007/270593; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

EXAMPLE I Preparation of dimethyl 4-amino-5-t-butylphthalate A mixture of 70 g. of 4-t-butylphthalic anhydride and 65 ml. of concentrated sulfuric acid was stirred at room temperature while adding 60 ml. of 90% nitric acid. The rate of addition was slow and controlled such that the temperture of the mixture did not go above 60 C, although the nitration reaction can be carried out at any temperature within the range of -20 to 120 C. After the addition was complete (2 hours) an additional 50 ml. of concentrated nitric acid was added over a 20 minute period. The reaction mixture was allowed to cool and was then stirred for 4 days. The mixture was then poured onto 800 g. of ice and the layers allowed to separate. The upper layer (water and acid) was decanted off and the residue dissolved in 500 ml. of ether. The ether solution was washed five times with 100 ml. of water, dried with MgSO4, filtered, and the ether removed under reduced pressure. The residual oil was esterified with 150 ml. of trimethyl orthoacetate by mixing the two and distilling off methanol, methyl acetate, and the excess reagent. The crude product was mixed with 400 ml. of methanol and cooled to 10 C. for 20 hours. Filtering and drying gave 33.2 g. of crystalline material. Recrystallization from methanol (125 ml.) gave 30.1 g. of pure dimethyl 4-nitro-5-t-butylphthalate, m.p. 80 -81 C.

32703-79-0, The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Standard Oil Company; US4078142; (1978); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem