Heterocyclic Building Block-benzofuran

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.1.20 5,6-Dichlorophthalide (41) Anhydride 40 (9.53 g, 42.6 mmol) was dissolved with stirring in THF (80 mL) and the solution was cooled to 0 ¡ãC under an Ar atmosphere. NaBH4 (1.63 g, 43.1 mmol) was added slowly in a single portion, and the mixture was stirred with cooling to 0 ¡ãC for 50 min. The mixture was removed from the ice-water bath and warmed to room temperature for 17 h. MeOH (20 mL) was added slowly and cautiously to the obtained suspension. The mixture was concentrated in vacuo. Dilute, aqueous HCl (0.1 M, 24 mL) was added to the residue. After stirring the mixture for 10 min, it was filtered. The collected solids were vigorously heated at reflux in PhMe (100 mL) with pTsOH¡¤H2O (0.15 g), using a Dean-Stark trap to collect H2O, for 30 h 15 min. The mixture was concentrated in vacuo. The residue was washed with H2O (50 mL) and the solid was azeotroped with PhMe (10 mL) and dried under high vacuum to provide 41 (6.41 g, 74percent) as a white solid, Rf (SiO2, CHCl3) 0.55: mp 157-160 ¡ãC. 1H NMR (300 MHz, DMSO-d6) delta 8.14 (s, 1H), 8.04 (s, 1H), 5.40 (s, 2H); CIMS m/z (rel intensity) 203/205/207 (MH+, 100/71/14)., 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69604-00-8,Ethyl 5-nitrobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

69604-00-8, Ethyl 2-nitrobenzofuran-2-carboxylate (23.5 g) prepared according to Example 4 was added to a reaction flask, 200 ml of ethanol was added, 3 g of 5% palladium carbon was added, and the mixture was replaced with hydrogen 3 times.The hydrogen pressure was controlled to be 0.4-0.5 MPa, hydrogenation reaction was performed at 30 C. for 3 hours, the reaction was completed, and the reaction was filtered. The filtrate was concentrated under reduced pressure to dryness to obtain 19.5 g of 5-aminobenzofuran-2-carboxylic acid ethyl ester.Yield 95.1%, purity 98.8%.

69604-00-8 Ethyl 5-nitrobenzofuran-2-carboxylate 1382954, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Lianyungang Hengyun Pharmaceutical Co., Ltd.; Dong Shuqiu; Feng Ruimao; Zhang Qingjie; (8 pag.)CN107540646; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection conditions, 5 mL of anhydrous dichloromethane was added3-methylbenzofuran-2-carboxylic acid (19 mg, 0.11 mmol)After stirring at room temperature, HOBt (18 mg, 0.13 mmol) was added,After stirring for 10 minutes, EDC ¡¤ HCl (25 mg,0.13 mmol) followed by the addition of compound III-8-a of Example 6(50 mg, 0.17 mmol) and DIPEA (0.04 mL, 0.22 mmol)TLC after 12 hours showed complete reaction,The reaction solution was washed with 5% NaHCO3 solution, 10% citric acid solution,5% NaHCO3 solution and saturated brine,Adding to the organic phase anhydrous sodium sulfate drying, drying and filtering,The solvent was removed using a rotary evaporator and the product was added directly to 5 mL of methanol,After stirring at room temperature, 2-methylpropylboronic acid (22 mg, 0.22 mmol) was added5 mL of n-hexane, followed by the addition of 1 M HCl solution (0.33 mL, 0.33 mmol)After 5 hours, the TLC assay showed complete reaction, the reaction solution was allowed to stand,The lower layer was washed with n-hexane, dried over anhydrous sodium sulfate,Drying after filtration, the use of rotary evaporator in addition to solvent,Column chromatography (dichloromethane: methanol = 60: 1) gave 16 mg of a white solid,Yield 50%.

24673-56-1, The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Shao Liming; Xu Yulong; Chen Yiyi; Li Wei; Xie Qiong; (36 pag.)CN107151255; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

57319-65-0, A solution of 400 mg (1.44 mM) of 4-chloro-6,7-diethoxy-quinoline-3-carbonitrile, 230 mg (1.54 mM) of 6-Aminophthalide and 161 mg of pyridine hydrochloride in 12 ml of 2-methoxyethanol was refluxed for 3 hours. To the warm solution was added 1 ml of 1M sodium carbonate and the sample was heated for 5 minutes at 100C, then poured into 300 ml of ice water. The solid was collected, washed with water followed by ether and dried under vacuum at 80C to yield 535 mg of 6,7-Diethoxy-4-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-quinoline-3-carbonitrile as a white solid: mass spectrum (electrospray, m/e): M+H 390.1, mp = 280-284C.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

61090-37-7, 2,3-Dihydrobenzofuran-4-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2,3-dihydro-4-benzofuranamine (72.3 g, 0.54 mol), hydroxylamine hydrochloride (131.3 g, 1.8 mol), conc. hydrochloric acid (45 mL) and water (1265 mL) was stirred at room temperature for 30 min. A solution of chloral hydrate (98.2 g, 0.59 mol) in water (1265 mL) was added followed by solid sodium sulphate (767 g, 5.4 mol) and the reaction was heated to reflux for 1 h. The reaction was cooled to room temperature and the solid was collected by filtration. The solid was suspended in ethyl acetate (250 mL) and water (250 mL) and then extracted with ethyl acetate (3*250 mL). The organic extracts were combined, dried (magnesium sulphate) and concentrated in vacuo to afford the title compound (41 g, 38%) as a pale brown solid; NMR (400 MHz, DMSO-d6) deltaH 3.12 (2H, t, J 9.0 Hz), 4.52 (2H, t, J 8.5 Hz), 6.58 (1H, d, J 8.0 Hz), 7.06 (1H, t, J 8.5 Hz), 7.14 (1H, d, J 8.5 Hz), 7.7 (1H, s), 9.66 (1H, br s), 12.19 (1H, br s); IR numax (Nujol)/cm-1 3389, 3160, 2923, 1661, 1620, 1607, 1540, 1453, 1238, 1060, 1029, 982 and 780., 61090-37-7

The synthetic route of 61090-37-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERNALIS RESEARCH LIMITED; US2005/187282; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a reaction tube were added 20 mol % CuI, 20 mol % KI (or Xphos), 0.25 mmol heterocycles, 3.0 equiv DTBP, and 1.5 mL cyclic ethers under a nitrogen atmosphere. The resulting mixture was heated at 120 C. After 24 h, the solvent was removed under vacuum, and the residue was purified by flash chromatography (SiO2, petroleum ether/ethyl acetate10:1)., 13391-28-1

13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Chenyang; Gong, Ming; Huang, Mengmeng; Li, Yabo; Kim, Jung Keun; Wu, Yangjie; Tetrahedron; vol. 72; 49; (2016); p. 7931 – 7936;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 2,3-Dihydrobenzofuran-5-amine (1A) (2.0g, 14 . 80mmol) is added to the hydrochloric acid in (14.6 ml, 3N), cooling to -5 ¡ãC, dropping sodium nitrite (1.2g, 17 . 80mmol) of water (8 ml) solution, after dripping, in 0 ¡ãC reaction 30 minutes, slowly adding sodium acetate (2.1g, 25 . 6mmol), adjusting reaction solution pH=5-6, in 0-5 ¡ãC lower, dropping ethyl 2-chloroacetoacetate(2.4g, 14 . 80mmol) methanol (5 ml) solution, to reaction at room temperature 2 hours. Adding ethyl acetate to the reaction solution (20 ml), liquid, organic phase with saturated salt water (30 ml) washing, dry anhydrous sodium sulfate, filtered, concentrated under reduced pressure, the residue is purified by silica gel column chromatography (ethyl acetate/petroleum ether (v/v) =1:99-1:9) to obtain the title compound ethyl 2-chloro-2-(2-(2,3-dihydrobenzofuran-5-yl)hydrazono)acetate(1B), yellow solid (200 mg, yield 5percent).

42933-43-7, As the paragraph descriping shows that 42933-43-7 is playing an increasingly important role.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) was heated at reflux in SOCl2 (5?10 equiv) for 4 h at 100 ¡ãC. The remaining SOCl2 was removed in vacu-um and the obtained solid was dissolved in CH2Cl2 (10 mL). The mix-ture was cooled to 0 ¡ãC and the desired primary amine (2.0 equiv)was slowly added. The solution was stirred for 24 h at r.t. then thereaction mixture was diluted with EtOAc (70 mL), washed with citricacid (0.5 M), sat. aq Na2CO3 solution, and brine. The organic layer wasdried over MgSO4 and the solvent was removed under reduced pres-sure. The obtained products were used without further purification.

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem